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Pharmacological degradation of ATR induces antiproliferative DNA replication stress in leukemic cells.
Mol Oncol. 2024 Mar 22. doi: 10.1002/1878-0261.13638. Online ahead of print.
Mol Oncol. 2024.
PMID: 38520049
Free article.
Design, synthesis, and biological characterization of proteolysis targeting chimera (PROTACs) for the ataxia telangiectasia and RAD3-related (ATR) kinase.
Alfayomy AM, Ashry R, Kansy AG, Sarnow AC, Erdmann F, Schmidt M, Krämer OH, Sippl W.
Alfayomy AM, et al.
Eur J Med Chem. 2024 Mar 5;267:116167. doi: 10.1016/j.ejmech.2024.116167. Epub 2024 Jan 29.
Eur J Med Chem. 2024.
PMID: 38308949
Free article.
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A Novel Approach for the Availability and Ocular Delivery of Tenoxicam Potassium: Synthesis, Characterization, and In Vivo Application.
Osman SK, Yassin TM, Mohammed AM, Alfayomy AM, Abdellatif AA, Mahdi WA, Alshehri S, Hamd MAE, Sarhan H, Ibrahim MA.
Osman SK, et al. Among authors: alfayomy am.
AAPS PharmSciTech. 2023 Jan 26;24(1):44. doi: 10.1208/s12249-022-02487-3.
AAPS PharmSciTech. 2023.
PMID: 36703092
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Crystal structure and Hirshfeld surface analysis of ethyl (3E)-5-(4-fluoro-phen-yl)3-{[(4-meth-oxy-phen-yl)formamido]-imino}-7-methyl-2H,3H,5H-[1,3]thia-zolo[3,2-a]pyrimidine-6-carboxyl-ate 0.25-hydrate.
Mohamed SK, Mague JT, Akkurt M, Alfayomy AM, Ragab FAF, Abd Ul-Malik MA.
Mohamed SK, et al. Among authors: alfayomy am.
Acta Crystallogr E Crystallogr Commun. 2022 Aug 9;78(Pt 9):880-884. doi: 10.1107/S2056989022006041. eCollection 2022 Sep 1.
Acta Crystallogr E Crystallogr Commun. 2022.
PMID: 36072522
Free PMC article.
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Crystal structure and Hirshfeld surface analysis of ethyl (3E)-5-(4-chloro-phen-yl)-3-{[(4-chloro-phen-yl)formamido]-imino}-7-methyl-2H,3H,5H-[1,3]thia-zolo[3,2-a]pyrimidine-6-carboxyl-ate.
Mohamed SK, Mague JT, Akkurt M, Alfayomy AM, Seri SMA, Abdel-Raheem SAA, Ul-Malik MAA.
Mohamed SK, et al. Among authors: alfayomy am.
Acta Crystallogr E Crystallogr Commun. 2022 Jul 26;78(Pt 8):846-850. doi: 10.1107/S205698902200603X. eCollection 2022 Aug 1.
Acta Crystallogr E Crystallogr Commun. 2022.
PMID: 35974819
Free PMC article.
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Design and synthesis of pyrimidine-5-carbonitrile hybrids as COX-2 inhibitors: Anti-inflammatory activity, ulcerogenic liability, histopathological and docking studies.
Alfayomy AM, Abdel-Aziz SA, Marzouk AA, Shaykoon MSA, Narumi A, Konno H, Abou-Seri SM, Ragab FAF.
Alfayomy AM, et al.
Bioorg Chem. 2021 Mar;108:104555. doi: 10.1016/j.bioorg.2020.104555. Epub 2020 Dec 15.
Bioorg Chem. 2021.
PMID: 33376011
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Design, synthesis and anticancer activity of new monastrol analogues bearing 1,3,4-oxadiazole moiety.
Ragab FAF, Abou-Seri SM, Abdel-Aziz SA, Alfayomy AM, Aboelmagd M.
Ragab FAF, et al. Among authors: alfayomy am.
Eur J Med Chem. 2017 Sep 29;138:140-151. doi: 10.1016/j.ejmech.2017.06.026. Epub 2017 Jun 15.
Eur J Med Chem. 2017.
PMID: 28667871
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