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The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir.
Dinh T, Tber Z, Rey JS, Mengshetti S, Annamalai AS, Haney R, Briganti L, Amblard F, Fuchs JR, Cherepanov P, Kim K, Schinazi RF, Perilla JR, Kim B, Kvaratskhelia M. Dinh T, et al. Among authors: mengshetti s. bioRxiv [Preprint]. 2024 Jan 26:2024.01.26.577387. doi: 10.1101/2024.01.26.577387. bioRxiv. 2024. PMID: 38328097 Free PMC article. Preprint.
Agonist of RORA Attenuates Nonalcoholic Fatty Liver Progression in Mice via Up-regulation of MicroRNA 122.
Chai C, Cox B, Yaish D, Gross D, Rosenberg N, Amblard F, Shemuelian Z, Gefen M, Korach A, Tirosh O, Lanton T, Link H, Tam J, Permyakova A, Ozhan G, Citrin J, Liao H, Tannous M, Hahn M, Axelrod J, Arretxe E, Alonso C, Martinez-Arranz I, Betés PO, Safadi R, Salhab A, Amer J, Tber Z, Mengshetti S, Giladi H, Schinazi RF, Galun E. Chai C, et al. Among authors: mengshetti s. Gastroenterology. 2020 Sep;159(3):999-1014.e9. doi: 10.1053/j.gastro.2020.05.056. Epub 2020 May 22. Gastroenterology. 2020. PMID: 32450149 Free PMC article.
Nucleoside Analogs with Antiviral Activity against Yellow Fever Virus.
Zandi K, Amblard F, Amichai S, Bassit L, Tao S, Jiang Y, Zhou L, Ollinger Russell O, Mengshetti S, Schinazi RF. Zandi K, et al. Among authors: mengshetti s. Antimicrob Agents Chemother. 2019 Aug 23;63(9):e00889-19. doi: 10.1128/AAC.00889-19. Print 2019 Sep. Antimicrob Agents Chemother. 2019. PMID: 31262759 Free PMC article.
Synthesis and anti-HCV activity of β-d-2'-deoxy-2'-α-chloro-2'-β-fluoro and β-d-2'-deoxy-2'-α-bromo-2'-β-fluoro nucleosides and their phosphoramidate prodrugs.
Ovadia R, Khalil A, Li H, De Schutter C, Mengshetti S, Zhou S, Bassit L, Coats SJ, Amblard F, Schinazi RF. Ovadia R, et al. Among authors: mengshetti s. Bioorg Med Chem. 2019 Feb 15;27(4):664-676. doi: 10.1016/j.bmc.2019.01.005. Epub 2019 Jan 9. Bioorg Med Chem. 2019. PMID: 30655167 Free PMC article.
Discovery of a Series of 2'-α-Fluoro,2'-β-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus.
Mengshetti S, Zhou L, Sari O, De Schutter C, Zhang H, Cho JH, Tao S, Bassit LC, Verma K, Domaoal RA, Ehteshami M, Jiang Y, Ovadia R, Kasthuri M, Ollinger Russell O, McBrayer T, Whitaker T, Pattassery J, Pascual ML, Uher L, Lin BY, Lee S, Amblard F, Coats SJ, Schinazi RF. Mengshetti S, et al. J Med Chem. 2019 Feb 28;62(4):1859-1874. doi: 10.1021/acs.jmedchem.8b01300. Epub 2019 Feb 7. J Med Chem. 2019. PMID: 30653317 Free PMC article.