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Gcn2 structurally mimics and functionally repurposes the HisRS enzyme for the integrated stress response.
Proc Natl Acad Sci U S A. 2024 Aug 27;121(35):e2409628121. doi: 10.1073/pnas.2409628121. Epub 2024 Aug 20.
Proc Natl Acad Sci U S A. 2024.
PMID: 39163341
The search for pyruvate kinase-R activators; from a HTS screening hit via an impurity to the discovery of a lead series.
Yu C, Setti LQ, Nilar S, Li Z, Yu M, Partridge J, Choy R, Siu V, Strutt S, Zang R, Rademacher P, Bahmanjah S, Myslovaty Y, Zancanella M.
Yu C, et al. Among authors: bahmanjah s.
Bioorg Med Chem Lett. 2024 Sep 15;110:129865. doi: 10.1016/j.bmcl.2024.129865. Epub 2024 Jun 29.
Bioorg Med Chem Lett. 2024.
PMID: 38950758
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Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic.
Shurtleff VW, Layton ME, Parish CA, Perkins JJ, Schreier JD, Wang Y, Adam GC, Alvarez N, Bahmanjah S, Bahnck-Teets CM, Boyce CW, Burlein C, Cabalu TD, Campbell BT, Carroll SS, Chang W, de Lera Ruiz M, Dolgov E, Fay JF, Fox NG, Goh SL, Hartingh TJ, Hurzy DM, Kelly MJ 3rd, Klein DJ, Klingler FM, Krishnamurthy H, Kudalkar S, Mayhood TW, McKenna PM, Murray EM, Nahas D, Nawrat CC, Park S, Qian D, Roecker AJ, Sharma V, Shipe WD, Su J, Taggart RV, Truong Q, Wu Y, Zhou X, Zhuang N, Perlin DS, Olsen DB, Howe JA, McCauley JA.
Shurtleff VW, et al. Among authors: bahmanjah s.
J Med Chem. 2024 Mar 14;67(5):3935-3958. doi: 10.1021/acs.jmedchem.3c02248. Epub 2024 Feb 16.
J Med Chem. 2024.
PMID: 38365209
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Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1.
Ng S, Brueckner AC, Bahmanjah S, Deng Q, Johnston JM, Ge L, Duggal R, Habulihaz B, Barlock B, Ha S, Sadruddin A, Yeo C, Strickland C, Peier A, Henry B, Sherer EC, Partridge AW.
Ng S, et al. Among authors: bahmanjah s.
J Med Chem. 2022 Jul 19. doi: 10.1021/acs.jmedchem.2c00406. Online ahead of print.
J Med Chem. 2022.
PMID: 35853179
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Crystal Structure and Characterization of Human Heavy-Chain Only Antibodies Reveals a Novel, Stable Dimeric Structure Similar to Monoclonal Antibodies.
Mieczkowski C, Bahmanjah S, Yu Y, Baker J, Raghunathan G, Tomazela D, Hsieh M, McCoy M, Strickland C, Fayadat-Dilman L.
Mieczkowski C, et al. Among authors: bahmanjah s.
Antibodies (Basel). 2020 Nov 22;9(4):66. doi: 10.3390/antib9040066.
Antibodies (Basel). 2020.
PMID: 33266498
Free PMC article.
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Crystal structure of an adenovirus virus-associated RNA.
Hood IV, Gordon JM, Bou-Nader C, Henderson FE, Bahmanjah S, Zhang J.
Hood IV, et al. Among authors: bahmanjah s.
Nat Commun. 2019 Jun 28;10(1):2871. doi: 10.1038/s41467-019-10752-6.
Nat Commun. 2019.
PMID: 31253805
Free PMC article.
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Monoacylglycerols as transmembrane Cl- anion transporters.
Bahmanjah S, Zhang N, Davis JT.
Bahmanjah S, et al.
Chem Commun (Camb). 2012 May 11;48(37):4432-4. doi: 10.1039/c2cc18148g. Epub 2012 Mar 29.
Chem Commun (Camb). 2012.
PMID: 22457876
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