Pointon A - Search Results

1

Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes.

Raniga K, Nasir A, Vo NTN, Vaidyanathan R, Dickerson S, Hilcove S, Mosqueira D, Mirams GR, Clements P, Hicks R, Pointon A, Stebbeds W, Francis J, Denning C. Raniga K, et al. Among authors: pointon a. Cell Stem Cell. 2024 Mar 7;31(3):292-311. doi: 10.1016/j.stem.2024.01.007. Epub 2024 Feb 15. Cell Stem Cell. 2024. PMID: 38366587 Free article. Review.

2

Deriving waveform parameters from calcium transients in human iPSC-derived cardiomyocytes to predict cardiac activity with machine learning.

Yang H, Stebbeds W, Francis J, Pointon A, Obrezanova O, Beattie KA, Clements P, Harvey JS, Smith GF, Bender A. Yang H, et al. Among authors: pointon a. Stem Cell Reports. 2022 Mar 8;17(3):556-568. doi: 10.1016/j.stemcr.2022.01.009. Epub 2022 Feb 10. Stem Cell Reports. 2022. PMID: 35148844 Free PMC article.

3

Prediction of inotropic effect based on calcium transients in human iPSC-derived cardiomyocytes and machine learning.

Yang H, Obrezanova O, Pointon A, Stebbeds W, Francis J, Beattie KA, Clements P, Harvey JS, Smith GF, Bender A. Yang H, et al. Among authors: pointon a. Toxicol Appl Pharmacol. 2023 Jan 15;459:116342. doi: 10.1016/j.taap.2022.116342. Epub 2022 Dec 9. Toxicol Appl Pharmacol. 2023. PMID: 36502871 Free article.

4

Information-Derived Mechanistic Hypotheses for Structural Cardiotoxicity.

Svensson F, Zoufir A, Mahmoud S, Afzal AM, Smit I, Giblin KA, Clements PJ, Mettetal JT, Pointon A, Harvey JS, Greene N, Williams RV, Bender A. Svensson F, et al. Among authors: pointon a. Chem Res Toxicol. 2018 Nov 19;31(11):1119-1127. doi: 10.1021/acs.chemrestox.8b00159. Epub 2018 Oct 17. Chem Res Toxicol. 2018. PMID: 30350600

5

Assessment of cardiomyocyte contraction in human-induced pluripotent stem cell-derived cardiomyocytes.

Pointon A, Harmer AR, Dale IL, Abi-Gerges N, Bowes J, Pollard C, Garside H. Pointon A, et al. Toxicol Sci. 2015 Apr;144(2):227-37. doi: 10.1093/toxsci/kfu312. Epub 2014 Dec 22. Toxicol Sci. 2015. PMID: 25538221

6

Assessment of extracellular field potential and Ca²⁺ transient signals for early QT/pro-arrhythmia detection using human induced pluripotent stem cell-derived cardiomyocytes.

Abi-Gerges N, Pointon A, Oldman KL, Brown MR, Pilling MA, Sefton CE, Garside H, Pollard CE. Abi-Gerges N, et al. Among authors: pointon a. J Pharmacol Toxicol Methods. 2017 Jan-Feb;83:1-15. doi: 10.1016/j.vascn.2016.09.001. Epub 2016 Sep 10. J Pharmacol Toxicol Methods. 2017. PMID: 27622857

7

Evolving Cardiac Safety in Drug Discovery: Time for Immunology Integration.

Vicencio JM, Archer CR, Pointon A. Vicencio JM, et al. Among authors: pointon a. Circulation. 2024 May 28;149(22):1704-1707. doi: 10.1161/CIRCULATIONAHA.123.068383. Epub 2024 May 28. Circulation. 2024. PMID: 38805578 No abstract available.

8

Current and future approaches to nonclinical cardiovascular safety assessment.

Collins TA, Rolf MG, Pointon A. Collins TA, et al. Among authors: pointon a. Drug Discov Today. 2020 Jul;25(7):1129-1134. doi: 10.1016/j.drudis.2020.03.011. Epub 2020 Mar 21. Drug Discov Today. 2020. PMID: 32209428 Free article.

9

From the Cover: High-Throughput Imaging of Cardiac Microtissues for the Assessment of Cardiac Contraction during Drug Discovery.

Pointon A, Pilling J, Dorval T, Wang Y, Archer C, Pollard C. Pointon A, et al. Toxicol Sci. 2017 Feb;155(2):444-457. doi: 10.1093/toxsci/kfw227. Epub 2016 Nov 15. Toxicol Sci. 2017. PMID: 28069985

10

Characterization and Validation of a Human 3D Cardiac Microtissue for the Assessment of Changes in Cardiac Pathology.

Archer CR, Sargeant R, Basak J, Pilling J, Barnes JR, Pointon A. Archer CR, et al. Among authors: pointon a. Sci Rep. 2018 Jul 5;8(1):10160. doi: 10.1038/s41598-018-28393-y. Sci Rep. 2018. PMID: 29976997 Free PMC article.

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