Ginn JD - Search Results

1

High-throughput screening identifies small molecule inhibitors of thioesterase superfamily member 1: Implications for the management of non-alcoholic fatty liver disease.

Krumm CS, Landzberg RS, Ramos-Espiritu L, Adura C, Liu X, Acuna M, Xie Y, Xu X, Tillman MC, Li Y, Glickman JF, Ortlund EA, Ginn JD, Cohen DE. Krumm CS, et al. Among authors: ginn jd. Mol Metab. 2023 Dec;78:101832. doi: 10.1016/j.molmet.2023.101832. Epub 2023 Oct 30. Mol Metab. 2023. PMID: 38403978 Free PMC article.

2

Shape-Based Virtual Screening of a Billion-Compound Library Identifies Mycobacterial Lipoamide Dehydrogenase Inhibitors.

Michino M, Beautrait A, Boyles NA, Nadupalli A, Dementiev A, Sun S, Ginn J, Baxt L, Suto R, Bryk R, Jerome SV, Huggins DJ, Vendome J. Michino M, et al. ACS Bio Med Chem Au. 2023 Sep 8;3(6):507-515. doi: 10.1021/acsbiomedchemau.3c00046. eCollection 2023 Dec 20. ACS Bio Med Chem Au. 2023. PMID: 38144256 Free PMC article.

3

Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: part 2, optimization for blood pressure reduction in spontaneously hypertensive rats.

Ginn JD, Bosanac T, Chen R, Cywin C, Hickey E, Kashem M, Kerr S, Kugler S, Li X, Prokopowicz A 3rd, Schlyer S, Smith JD, Turner MR, Wu F, Young ER. Ginn JD, et al. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5153-6. doi: 10.1016/j.bmcl.2010.07.014. Epub 2010 Aug 1. Bioorg Med Chem Lett. 2010. PMID: 20678931

4

Discovery of potent and selective PKC-theta inhibitors.

Cywin CL, Dahmann G, Prokopowicz AS 3rd, Young ER, Magolda RL, Cardozo MG, Cogan DA, Disalvo D, Ginn JD, Kashem MA, Wolak JP, Homon CA, Farrell TM, Grbic H, Hu H, Kaplita PV, Liu LH, Spero DM, Jeanfavre DD, O'Shea KM, White DM, Woska JR Jr, Brown ML. Cywin CL, et al. Among authors: ginn jd. Bioorg Med Chem Lett. 2007 Jan 1;17(1):225-30. doi: 10.1016/j.bmcl.2006.09.056. Epub 2006 Oct 19. Bioorg Med Chem Lett. 2007. PMID: 17055721

5

Studies on the synthesis of (+/-)-stenine: a combined intramolecular [4 + 2]-cycloaddition/rearrangement cascade.

Padwa A, Ginn JD. Padwa A, et al. Among authors: ginn jd. J Org Chem. 2005 Jun 24;70(13):5197-206. doi: 10.1021/jo050515e. J Org Chem. 2005. PMID: 15960524

6

Synthesis of azapolycyclic systems via the intramolecular [4 + 2] cycloaddition chemistry of 2-(alkylthio)-5-amidofurans.

Padwa A, Ginn JD, Bur SK, Eidell CK, Lynch SM. Padwa A, et al. Among authors: ginn jd. J Org Chem. 2002 May 17;67(10):3412-24. doi: 10.1021/jo0111816. J Org Chem. 2002. PMID: 12003554

7

Total synthesis of (+/-)-stenine using the IMDAF cycloaddition of a 2-methylthio-5-amido-substituted furan.

Ginn JD, Padwa A. Ginn JD, et al. Org Lett. 2002 May 2;4(9):1515-7. doi: 10.1021/ol025746b. Org Lett. 2002. PMID: 11975617

8

A new method for the preparation of 2-thio substituted furans by methylsulfanylation of gamma-dithiane carbonyl compounds.

Padwa A, Eidell CK, Ginn JD, McClure MS. Padwa A, et al. Among authors: ginn jd. J Org Chem. 2002 Mar 8;67(5):1595-606. doi: 10.1021/jo010986a. J Org Chem. 2002. PMID: 11871892

9

Methylsulfenylation of thioacetals as a method for synthesizing 2-thio-substituted furans.

Padwa A, Ginn JD, McClure MS. Padwa A, et al. Among authors: ginn jd. Org Lett. 1999 Nov 18;1(10):1559-61. doi: 10.1021/ol990865l. Org Lett. 1999. PMID: 10836023

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