Bolon DNA - Search Results

1

Contributions of Hyperactive Mutations in M^pro from SARS-CoV-2 to Drug Resistance.

Flynn JM, Zvornicanin SN, Tsepal T, Shaqra AM, Kurt Yilmaz N, Jia W, Moquin S, Dovala D, Schiffer CA, Bolon DNA. Flynn JM, et al. Among authors: bolon dna. ACS Infect Dis. 2024 Apr 12;10(4):1174-1184. doi: 10.1021/acsinfecdis.3c00560. Epub 2024 Mar 12. ACS Infect Dis. 2024. PMID: 38472113

2

Comprehensive fitness landscape of SARS-CoV-2 M^pro reveals insights into viral resistance mechanisms.

Flynn JM, Samant N, Schneider-Nachum G, Barkan DT, Yilmaz NK, Schiffer CA, Moquin SA, Dovala D, Bolon DNA. Flynn JM, et al. Among authors: bolon dna. Elife. 2022 Jun 20;11:e77433. doi: 10.7554/eLife.77433. Elife. 2022. PMID: 35723575 Free PMC article.

3

Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance.

Shaqra AM, Zvornicanin SN, Huang QYJ, Lockbaum GJ, Knapp M, Tandeske L, Bakan DT, Flynn J, Bolon DNA, Moquin S, Dovala D, Kurt Yilmaz N, Schiffer CA. Shaqra AM, et al. Among authors: bolon dna. Nat Commun. 2022 Jun 21;13(1):3556. doi: 10.1038/s41467-022-31210-w. Nat Commun. 2022. PMID: 35729165 Free PMC article.

4

Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV-2 Main Protease.

Flynn JM, Huang QYJ, Zvornicanin SN, Schneider-Nachum G, Shaqra AM, Yilmaz NK, Moquin SA, Dovala D, Schiffer CA, Bolon DNA. Flynn JM, et al. Among authors: bolon dna. ACS Infect Dis. 2023 Jul 14;9(7):1372-1386. doi: 10.1021/acsinfecdis.3c00125. Epub 2023 Jun 30. ACS Infect Dis. 2023. PMID: 37390404

5

Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance.

Henes M, Lockbaum GJ, Kosovrasti K, Leidner F, Nachum GS, Nalivaika EA, Lee SK, Spielvogel E, Zhou S, Swanstrom R, Bolon DNA, Kurt Yilmaz N, Schiffer CA. Henes M, et al. Among authors: bolon dna. ACS Chem Biol. 2019 Nov 15;14(11):2441-2452. doi: 10.1021/acschembio.9b00370. Epub 2019 Aug 13. ACS Chem Biol. 2019. PMID: 31361460 Free PMC article.

6

Analyses of HIV proteases variants at the threshold of viability reveals relationships between processing efficiency and fitness.

Schneider-Nachum G, Flynn J, Mavor D, Schiffer CA, Bolon DNA. Schneider-Nachum G, et al. Among authors: bolon dna. Virus Evol. 2021 Dec 14;7(2):veab103. doi: 10.1093/ve/veab103. eCollection 2021 Sep. Virus Evol. 2021. PMID: 35299788 Free PMC article.

7

Hydrophobic core flexibility modulates enzyme activity in HIV-1 protease.

Mittal S, Cai Y, Nalam MN, Bolon DN, Schiffer CA. Mittal S, et al. J Am Chem Soc. 2012 Mar 7;134(9):4163-8. doi: 10.1021/ja2095766. Epub 2012 Feb 28. J Am Chem Soc. 2012. PMID: 22295904 Free PMC article.

8

Mechanistic Asymmetry in Hsp90 Dimers.

Flynn JM, Mishra P, Bolon DN. Flynn JM, et al. J Mol Biol. 2015 Sep 11;427(18):2904-11. doi: 10.1016/j.jmb.2015.03.017. Epub 2015 Apr 3. J Mol Biol. 2015. PMID: 25843003 Free PMC article. Review.

9

Sequence dependencies and biophysical features both govern cleavage of diverse cut-sites by HIV protease.

Samant N, Nachum G, Tsepal T, Bolon DNA. Samant N, et al. Among authors: bolon dna. Protein Sci. 2022 Jul;31(7):e4366. doi: 10.1002/pro.4366. Protein Sci. 2022. PMID: 35762719 Free PMC article.

10

Mutational fitness landscape and drug resistance.

Flynn J, Samant N, Schneider-Nachum G, Tenzin T, Bolon DNA. Flynn J, et al. Among authors: bolon dna. Curr Opin Struct Biol. 2023 Feb;78:102525. doi: 10.1016/j.sbi.2022.102525. Epub 2023 Jan 6. Curr Opin Struct Biol. 2023. PMID: 36621152 Free PMC article. Review.

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