Schiffer CA - Search Results

1

Contributions of Hyperactive Mutations in M^pro from SARS-CoV-2 to Drug Resistance.

Flynn JM, Zvornicanin SN, Tsepal T, Shaqra AM, Kurt Yilmaz N, Jia W, Moquin S, Dovala D, Schiffer CA, Bolon DNA. Flynn JM, et al. Among authors: schiffer ca. ACS Infect Dis. 2024 Apr 12;10(4):1174-1184. doi: 10.1021/acsinfecdis.3c00560. Epub 2024 Mar 12. ACS Infect Dis. 2024. PMID: 38472113

2

Comprehensive fitness landscape of SARS-CoV-2 M^pro reveals insights into viral resistance mechanisms.

Flynn JM, Samant N, Schneider-Nachum G, Barkan DT, Yilmaz NK, Schiffer CA, Moquin SA, Dovala D, Bolon DNA. Flynn JM, et al. Among authors: schiffer ca. Elife. 2022 Jun 20;11:e77433. doi: 10.7554/eLife.77433. Elife. 2022. PMID: 35723575 Free PMC article.

3

Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance.

Shaqra AM, Zvornicanin SN, Huang QYJ, Lockbaum GJ, Knapp M, Tandeske L, Bakan DT, Flynn J, Bolon DNA, Moquin S, Dovala D, Kurt Yilmaz N, Schiffer CA. Shaqra AM, et al. Among authors: schiffer ca. Nat Commun. 2022 Jun 21;13(1):3556. doi: 10.1038/s41467-022-31210-w. Nat Commun. 2022. PMID: 35729165 Free PMC article.

4

Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV-2 Main Protease.

Flynn JM, Huang QYJ, Zvornicanin SN, Schneider-Nachum G, Shaqra AM, Yilmaz NK, Moquin SA, Dovala D, Schiffer CA, Bolon DNA. Flynn JM, et al. Among authors: schiffer ca. ACS Infect Dis. 2023 Jul 14;9(7):1372-1386. doi: 10.1021/acsinfecdis.3c00125. Epub 2023 Jun 30. ACS Infect Dis. 2023. PMID: 37390404

5

Cooperative effects of drug-resistance mutations in the flap region of HIV-1 protease.

Foulkes-Murzycki JE, Rosi C, Kurt Yilmaz N, Shafer RW, Schiffer CA. Foulkes-Murzycki JE, et al. Among authors: schiffer ca. ACS Chem Biol. 2013 Mar 15;8(3):513-8. doi: 10.1021/cb3006193. Epub 2012 Dec 27. ACS Chem Biol. 2013. PMID: 23252515 Free PMC article.

6

Improving Viral Protease Inhibitors to Counter Drug Resistance.

Kurt Yilmaz N, Swanstrom R, Schiffer CA. Kurt Yilmaz N, et al. Among authors: schiffer ca. Trends Microbiol. 2016 Jul;24(7):547-557. doi: 10.1016/j.tim.2016.03.010. Epub 2016 Apr 15. Trends Microbiol. 2016. PMID: 27090931 Free PMC article. Review.

7

Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance.

Henes M, Lockbaum GJ, Kosovrasti K, Leidner F, Nachum GS, Nalivaika EA, Lee SK, Spielvogel E, Zhou S, Swanstrom R, Bolon DNA, Kurt Yilmaz N, Schiffer CA. Henes M, et al. Among authors: schiffer ca. ACS Chem Biol. 2019 Nov 15;14(11):2441-2452. doi: 10.1021/acschembio.9b00370. Epub 2019 Aug 13. ACS Chem Biol. 2019. PMID: 31361460 Free PMC article.

8

Introduction: Drug Resistance.

Kurt Yilmaz N, Schiffer CA. Kurt Yilmaz N, et al. Among authors: schiffer ca. Chem Rev. 2021 Mar 24;121(6):3235-3237. doi: 10.1021/acs.chemrev.1c00118. Chem Rev. 2021. PMID: 33757288 Free PMC article. No abstract available.

9

Deciphering Complex Mechanisms of Resistance and Loss of Potency through Coupled Molecular Dynamics and Machine Learning.

Leidner F, Kurt Yilmaz N, Schiffer CA. Leidner F, et al. Among authors: schiffer ca. J Chem Theory Comput. 2021 Apr 13;17(4):2054-2064. doi: 10.1021/acs.jctc.0c01244. Epub 2021 Mar 30. J Chem Theory Comput. 2021. PMID: 33783217 Free PMC article.

10

Deciphering Antifungal Drug Resistance in Pneumocystis jirovecii DHFR with Molecular Dynamics and Machine Learning.

Leidner F, Kurt Yilmaz N, Schiffer CA. Leidner F, et al. Among authors: schiffer ca. J Chem Inf Model. 2021 Jun 28;61(6):2537-2541. doi: 10.1021/acs.jcim.1c00403. Epub 2021 Jun 17. J Chem Inf Model. 2021. PMID: 34138546 Free PMC article.

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