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Large-scale data mining of four billion human antibody variable regions reveals convergence between therapeutic and natural antibodies that constrains search space for biologics drug discovery.
MAbs. 2024 Jan-Dec;16(1):2361928. doi: 10.1080/19420862.2024.2361928. Epub 2024 Jun 6.
MAbs. 2024.
PMID: 38844871
Free PMC article.
Benchmarking antibody clustering methods using sequence, structural, and machine learning similarity measures for antibody discovery applications.
Chomicz D, Kończak J, Wróbel S, Satława T, Dudzic P, Janusz B, Tarkowski M, Deszyński P, Gawłowski T, Kostyn A, Orłowski M, Klaus T, Schulte L, Martin K, Comeau SR, Krawczyk K.
Chomicz D, et al. Among authors: satlawa t.
Front Mol Biosci. 2024 Mar 28;11:1352508. doi: 10.3389/fmolb.2024.1352508. eCollection 2024.
Front Mol Biosci. 2024.
PMID: 38606289
Free PMC article.
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nanoBERT: a deep learning model for gene agnostic navigation of the nanobody mutational space.
Hadsund JT, Satława T, Janusz B, Shan L, Zhou L, Röttger R, Krawczyk K.
Hadsund JT, et al. Among authors: satlawa t.
Bioinform Adv. 2024 Mar 6;4(1):vbae033. doi: 10.1093/bioadv/vbae033. eCollection 2024.
Bioinform Adv. 2024.
PMID: 38560554
Free PMC article.
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LAP: Liability Antibody Profiler by sequence & structural mapping of natural and therapeutic antibodies.
Satława T, Tarkowski M, Wróbel S, Dudzic P, Gawłowski T, Klaus T, Orłowski M, Kostyn A, Kumar S, Buchanan A, Krawczyk K.
Satława T, et al.
PLoS Comput Biol. 2024 Mar 5;20(3):e1011881. doi: 10.1371/journal.pcbi.1011881. eCollection 2024 Mar.
PLoS Comput Biol. 2024.
PMID: 38442111
Free PMC article.
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Structural modeling of antibody variable regions using deep learning-progress and perspectives on drug discovery.
Jaszczyszyn I, Bielska W, Gawlowski T, Dudzic P, Satława T, Kończak J, Wilman W, Janusz B, Wróbel S, Chomicz D, Galson JD, Leem J, Kelm S, Krawczyk K.
Jaszczyszyn I, et al. Among authors: satlawa t.
Front Mol Biosci. 2023 Jul 7;10:1214424. doi: 10.3389/fmolb.2023.1214424. eCollection 2023.
Front Mol Biosci. 2023.
PMID: 37484529
Free PMC article.
Review.
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Machine-designed biotherapeutics: opportunities, feasibility and advantages of deep learning in computational antibody discovery.
Wilman W, Wróbel S, Bielska W, Deszynski P, Dudzic P, Jaszczyszyn I, Kaniewski J, Młokosiewicz J, Rouyan A, Satława T, Kumar S, Greiff V, Krawczyk K.
Wilman W, et al. Among authors: satlawa t.
Brief Bioinform. 2022 Jul 18;23(4):bbac267. doi: 10.1093/bib/bbac267.
Brief Bioinform. 2022.
PMID: 35830864
Free PMC article.
Review.
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