Integrated pathway mining and selection of an artificial CYP79-mediated bypass to improve benzylisoquinoline alkaloid biosynthesis.
Takenaka M, Kamasaka K, Daryong K, Tsuchikane K, Miyazawa S, Fujihana S, Hori Y, Vavricka CJ, Hosoyama A, Kawasaki H, Shirai T, Araki M, Nakagawa A, Minami H, Kondo A, Hasunuma T.
Takenaka M, et al.
Microb Cell Fact. 2024 Jun 15;23(1):178. doi: 10.1186/s12934-024-02453-7.
Microb Cell Fact. 2024.
PMID: 38879464
Free PMC article.
The early bottleneck of BIA production in Escherichia coli consists of 3,4-dihydroxyphenylacetaldehyde (DHPAA) production and conversion to tetrahydropapaveroline (THP). Previous studies have selected monoamine oxidase (MAO) and DHPAA synthase (DHPAAS) to produce DH …
The early bottleneck of BIA production in Escherichia coli consists of 3,4-dihydroxyphenylacetaldehyde (DHPAA) production and conversion to …