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Discovery and Derivatization of Tridecaptin Antibiotics with Altered Host Specificity and Enhanced Bioactivity.
Machushynets NV, Al Ayed K, Terlouw BR, Du C, Buijs NP, Willemse J, Elsayed SS, Schill J, Trebosc V, Pieren M, Alexander FM, Cochrane SA, Liles MR, Medema MH, Martin NI, van Wezel GP. Machushynets NV, et al. Among authors: martin ni. ACS Chem Biol. 2024 May 17;19(5):1106-1115. doi: 10.1021/acschembio.4c00034. Epub 2024 Apr 11. ACS Chem Biol. 2024. PMID: 38602492 Free PMC article.
Potent Inhibition of Nicotinamide N-Methyltransferase by Alkene-Linked Bisubstrate Mimics Bearing Electron Deficient Aromatics.
Gao Y, van Haren MJ, Buijs N, Innocenti P, Zhang Y, Sartini D, Campagna R, Emanuelli M, Parsons RB, Jespers W, Gutiérrez-de-Terán H, van Westen GJP, Martin NI. Gao Y, et al. Among authors: martin ni. J Med Chem. 2021 Sep 9;64(17):12938-12963. doi: 10.1021/acs.jmedchem.1c01094. Epub 2021 Aug 23. J Med Chem. 2021. PMID: 34424711 Free PMC article.
Macrocyclic peptides as allosteric inhibitors of nicotinamide N-methyltransferase (NNMT).
van Haren MJ, Zhang Y, Thijssen V, Buijs N, Gao Y, Mateuszuk L, Fedak FA, Kij A, Campagna R, Sartini D, Emanuelli M, Chlopicki S, Jongkees SAK, Martin NI. van Haren MJ, et al. Among authors: martin ni. RSC Chem Biol. 2021 Aug 19;2(5):1546-1555. doi: 10.1039/d1cb00134e. eCollection 2021 Oct 7. RSC Chem Biol. 2021. PMID: 34704059 Free PMC article.
Mechanistic insights into the C55-P targeting lipopeptide antibiotics revealed by structure-activity studies and high-resolution crystal structures.
Wood TM, Zeronian MR, Buijs N, Bertheussen K, Abedian HK, Johnson AV, Pearce NM, Lutz M, Kemmink J, Seirsma T, Hamoen LW, Janssen BJC, Martin NI. Wood TM, et al. Among authors: martin ni. Chem Sci. 2022 Feb 21;13(10):2985-2991. doi: 10.1039/d1sc07190d. eCollection 2022 Mar 9. Chem Sci. 2022. PMID: 35382464 Free PMC article.
Synthetic studies with the brevicidine and laterocidine lipopeptide antibiotics including analogues with enhanced properties and in vivo efficacy.
Al Ayed K, Ballantine RD, Hoekstra M, Bann SJ, Wesseling CMJ, Bakker AT, Zhong Z, Li YX, Brüchle NC, van der Stelt M, Cochrane SA, Martin NI. Al Ayed K, et al. Among authors: martin ni. Chem Sci. 2022 Feb 23;13(12):3563-3570. doi: 10.1039/d2sc00143h. eCollection 2022 Mar 24. Chem Sci. 2022. PMID: 35432860 Free PMC article.
Chemical Proteomics Reveals Antibiotic Targets of Oxadiazolones in MRSA.
Bakker AT, Kotsogianni I, Mirenda L, Straub VM, Avalos M, van den Berg RJBHN, Florea BI, van Wezel GP, Janssen APA, Martin NI, van der Stelt M. Bakker AT, et al. Among authors: martin ni. J Am Chem Soc. 2023 Jan 18;145(2):1136-1143. doi: 10.1021/jacs.2c10819. Epub 2022 Dec 30. J Am Chem Soc. 2023. PMID: 36584241 Free PMC article.
123 results