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Prion biology: implications for Alzheimer's disease therapeutics.
Condello C, DeGrado WF, Prusiner SB. Condello C, et al. Among authors: prusiner sb. Lancet Neurol. 2020 Oct;19(10):802-803. doi: 10.1016/S1474-4422(20)30274-X. Epub 2020 Sep 16. Lancet Neurol. 2020. PMID: 32949533 No abstract available.
Aβ and tau prions feature in the neuropathogenesis of Down syndrome.
Condello C, Maxwell AM, Castillo E, Aoyagi A, Graff C, Ingelsson M, Lannfelt L, Bird TD, Keene CD, Seeley WW, Perl DP, Head E, Prusiner SB. Condello C, et al. Among authors: prusiner sb. Proc Natl Acad Sci U S A. 2022 Nov 16;119(46):e2212954119. doi: 10.1073/pnas.2212954119. Epub 2022 Nov 7. Proc Natl Acad Sci U S A. 2022. PMID: 36343257 Free PMC article.
Aβ and tau prion-like activities decline with longevity in the Alzheimer's disease human brain.
Aoyagi A, Condello C, Stöhr J, Yue W, Rivera BM, Lee JC, Woerman AL, Halliday G, van Duinen S, Ingelsson M, Lannfelt L, Graff C, Bird TD, Keene CD, Seeley WW, DeGrado WF, Prusiner SB. Aoyagi A, et al. Among authors: prusiner sb. Sci Transl Med. 2019 May 1;11(490):eaat8462. doi: 10.1126/scitranslmed.aat8462. Sci Transl Med. 2019. PMID: 31043574 Free PMC article.
Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aβ prions.
Condello C, Ayers JI, Dalgard CL, Garcia Garcia MM, Rivera BM, Seeley WW, Perl DP, Prusiner SB. Condello C, et al. Among authors: prusiner sb. Proc Natl Acad Sci U S A. 2023 Mar 28;120(13):e2220984120. doi: 10.1073/pnas.2220984120. Epub 2023 Mar 23. Proc Natl Acad Sci U S A. 2023. PMID: 36952379 Free PMC article.
Serial propagation of distinct strains of Aβ prions from Alzheimer's disease patients.
Watts JC, Condello C, Stöhr J, Oehler A, Lee J, DeArmond SJ, Lannfelt L, Ingelsson M, Giles K, Prusiner SB. Watts JC, et al. Among authors: prusiner sb. Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10323-8. doi: 10.1073/pnas.1408900111. Epub 2014 Jun 30. Proc Natl Acad Sci U S A. 2014. PMID: 24982139 Free PMC article.
Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer's disease.
Condello C, Lemmin T, Stöhr J, Nick M, Wu Y, Maxwell AM, Watts JC, Caro CD, Oehler A, Keene CD, Bird TD, van Duinen SG, Lannfelt L, Ingelsson M, Graff C, Giles K, DeGrado WF, Prusiner SB. Condello C, et al. Among authors: prusiner sb. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E782-E791. doi: 10.1073/pnas.1714966115. Epub 2018 Jan 8. Proc Natl Acad Sci U S A. 2018. PMID: 29311311 Free PMC article.
A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells.
Stöhr J, Wu H, Nick M, Wu Y, Bhate M, Condello C, Johnson N, Rodgers J, Lemmin T, Acharya S, Becker J, Robinson K, Kelly MJS, Gai F, Stubbs G, Prusiner SB, DeGrado WF. Stöhr J, et al. Among authors: prusiner sb. Nat Chem. 2017 Sep;9(9):874-881. doi: 10.1038/nchem.2754. Epub 2017 Apr 3. Nat Chem. 2017. PMID: 28837163 Free PMC article.
571 results