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NASH triggers cardiometabolic HFpEF in aging mice.
Kucsera D, Ruppert M, Sayour NV, Tóth VE, Kovács T, Hegedűs ZI, Onódi Z, Fábián A, Kovács A, Radovits T, Merkely B, Pacher P, Ferdinandy P, Varga ZV. Kucsera D, et al. Among authors: pacher p. Geroscience. 2024 Oct;46(5):4517-4531. doi: 10.1007/s11357-024-01153-9. Epub 2024 Apr 17. Geroscience. 2024. PMID: 38630423 Free PMC article.
Droplet Digital PCR Is a Novel Screening Method Identifying Potential Cardiac G-Protein-Coupled Receptors as Candidate Pharmacological Targets in a Rat Model of Pressure-Overload-Induced Cardiac Dysfunction.
Sayour NV, Tóth VÉ, Nagy RN, Vörös I, Gergely TG, Onódi Z, Nagy N, Bödör C, Váradi B, Ruppert M, Radovits T, Bleckwedel F, Zelarayán LC, Pacher P, Ágg B, Görbe A, Ferdinandy P, Varga ZV. Sayour NV, et al. Among authors: pacher p. Int J Mol Sci. 2023 Sep 7;24(18):13826. doi: 10.3390/ijms241813826. Int J Mol Sci. 2023. PMID: 37762130 Free PMC article.
PCSK9, A Promising Novel Target for Age-Related Cardiovascular Dysfunction.
Matyas C, Trojnar E, Zhao S, Arif M, Mukhopadhyay P, Kovacs A, Fabian A, Tokodi M, Bagyura Z, Merkely B, Kohidai L, Lajko E, Takacs A, He Y, Gao B, Paloczi J, Lohoff FW, Haskó G, Ding WX, Pacher P. Matyas C, et al. Among authors: pacher p. JACC Basic Transl Sci. 2023 Sep 13;8(10):1334-1353. doi: 10.1016/j.jacbts.2023.06.005. eCollection 2023 Oct. JACC Basic Transl Sci. 2023. PMID: 38094682 Free PMC article.
PCSK9 inhibition attenuates alcohol-associated neuronal oxidative stress and cellular injury.
Wagner J, Park LM, Mukhopadhyay P, Matyas C, Trojnar E, Damadzic R, Jung J, Bell AS, Mavromatis LA, Hamandi AM, Rosoff DB, Vendruscolo LF, Koob GF, Pacher P, Lohoff FW. Wagner J, et al. Among authors: pacher p. Brain Behav Immun. 2024 Jul;119:494-506. doi: 10.1016/j.bbi.2024.04.022. Epub 2024 Apr 22. Brain Behav Immun. 2024. PMID: 38657842 Free article.
A Highly Potent, Orally Bioavailable Pyrazole-Derived Cannabinoid CB2 Receptor- Selective Full Agonist for In Vivo Studies.
Chicca A, Bátora D, Ullmer C, Caruso A, Grüner S, Fingerle J, Hartung T, Degen R, Müller M, Grether U, Pacher P, Gertsch J. Chicca A, et al. Among authors: pacher p. ACS Pharmacol Transl Sci. 2024 Jul 9;7(8):2424-2438. doi: 10.1021/acsptsci.4c00269. eCollection 2024 Aug 9. ACS Pharmacol Transl Sci. 2024. PMID: 39144568 Free article.
Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche's Endocannabinoid System Projects.
Aebi J, Atz K, Ametamey SM, Benz J, Blaising J, Butini S, Campiani G, Carreira EM, Collin L, De Lago E, Gazzi T, Gertsch J, Gobbi L, Guba W, Fernández-Ruiz J, Fingerle J, Haider A, He Y, Heitman LH, Honer M, Hunziker D, Kuhn B, Maccarrone M, Märki HP, Martin RE, Mohr P, Mu L, Nazaré M, Nippa DF, Oddi S, O'Hara F, Pacher P, Romero J, Röver S, Rufer AC, Schibli R, Schneider G, Stepan AF, Sykes DA, Ullmer C, Van der Stelt M, Veprintsev DB, Wittwer MB, Grether U. Aebi J, et al. Among authors: pacher p. Chimia (Aarau). 2024 Aug 21;78(7-8):499-512. doi: 10.2533/chimia.2024.499. Chimia (Aarau). 2024. PMID: 39221845 Free article.
A highly potent, orally bioavailable pyrazole-derived cannabinoid CB2 receptor-selective full agonist for in vivo studies.
Chicca A, Batora D, Ullmer C, Caruso A, Fingerle J, Hartung T, Degen R, Müller M, Grether U, Pacher P, Gertsch J. Chicca A, et al. Among authors: pacher p. bioRxiv [Preprint]. 2024 Apr 29:2024.04.26.591311. doi: 10.1101/2024.04.26.591311. bioRxiv. 2024. Update in: ACS Pharmacol Transl Sci. 2024 Jul 09;7(8):2424-2438. doi: 10.1021/acsptsci.4c00269. PMID: 38903103 Free PMC article. Updated. Preprint.
Coordinated action of a gut-liver pathway drives alcohol detoxification and consumption.
Fu Y, Mackowiak B, Lin YH, Maccioni L, Lehner T, Pan H, Guan Y, Godlewski G, Lu H, Chen C, Wei S, Feng D, Paloczi J, Zhou H, Pacher P, Zhang L, Kunos G, Gao B. Fu Y, et al. Among authors: pacher p. Nat Metab. 2024 Jul;6(7):1380-1396. doi: 10.1038/s42255-024-01063-2. Epub 2024 Jun 20. Nat Metab. 2024. PMID: 38902331
392 results