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mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome.
Johnson SC, Yanos ME, Kayser EB, Quintana A, Sangesland M, Castanza A, Uhde L, Hui J, Wall VZ, Gagnidze A, Oh K, Wasko BM, Ramos FJ, Palmiter RD, Rabinovitch PS, Morgan PG, Sedensky MM, Kaeberlein M. Johnson SC, et al. Among authors: sedensky mm. Science. 2013 Dec 20;342(6165):1524-8. doi: 10.1126/science.1244360. Epub 2013 Nov 14. Science. 2013. PMID: 24231806 Free PMC article.
Regional metabolic signatures in the Ndufs4(KO) mouse brain implicate defective glutamate/α-ketoglutarate metabolism in mitochondrial disease.
Johnson SC, Kayser EB, Bornstein R, Stokes J, Bitto A, Park KY, Pan A, Sun G, Raftery D, Kaeberlein M, Sedensky MM, Morgan PG. Johnson SC, et al. Among authors: sedensky mm. Mol Genet Metab. 2020 Jun;130(2):118-132. doi: 10.1016/j.ymgme.2020.03.007. Epub 2020 Apr 3. Mol Genet Metab. 2020. PMID: 32331968 Free PMC article.
Peripheral macrophages drive CNS disease in the Ndufs4(-/-) model of Leigh syndrome.
Hanaford AR, Khanna A, Truong V, James K, Chen Y, Mulholland M, Kayser B, Liao RW, Sedensky M, Morgan P, Baertsch NA, Kalia V, Sarkar S, Johnson SC. Hanaford AR, et al. Among authors: sedensky m. Brain Pathol. 2023 Nov;33(6):e13192. doi: 10.1111/bpa.13192. Epub 2023 Aug 8. Brain Pathol. 2023. PMID: 37552802 Free PMC article.
100 results