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Discovery of a brain penetrant small molecule antagonist targeting LPA1 receptors to reduce neuroinflammation and promote remyelination in multiple sclerosis.
Sci Rep. 2024 May 8;14(1):10573. doi: 10.1038/s41598-024-61369-9.
Sci Rep. 2024.
PMID: 38719983
Free PMC article.
Identification and In Vivo Evaluation of Myelination Agent PIPE-3297, a Selective Kappa Opioid Receptor Agonist Devoid of β-Arrestin-2 Recruitment Efficacy.
Schrader TO, Lorrain KI, Bagnol D, Edu GC, Broadhead A, Baccei C, Poon MM, Stebbins KJ, Xiong Y, Lorenzana AO, Chan JR, Green AJ, Lorrain DS, Chen A.
Schrader TO, et al. Among authors: edu gc.
ACS Chem Neurosci. 2024 Feb 7;15(3):685-698. doi: 10.1021/acschemneuro.3c00807. Epub 2024 Jan 24.
ACS Chem Neurosci. 2024.
PMID: 38265210
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