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Discovery of a brain penetrant small molecule antagonist targeting LPA1 receptors to reduce neuroinflammation and promote remyelination in multiple sclerosis.
Sci Rep. 2024 May 8;14(1):10573. doi: 10.1038/s41598-024-61369-9.
Sci Rep. 2024.
PMID: 38719983
Free PMC article.
Solvent-Controlled, Site-Selective N-Alkylation Reactions of Azolo-Fused Ring Heterocycles at N1-, N2-, and N3-Positions, Including Pyrazolo[3,4- d]pyrimidines, Purines, [1,2,3]Triazolo[4,5]pyridines, and Related Deaza-Compounds.
Bookser BC, Weinhouse MI, Burns AC, Valiere AN, Valdez LJ, Stanczak P, Na J, Rheingold AL, Moore CE, Dyck B.
Bookser BC, et al. Among authors: valdez lj.
J Org Chem. 2018 Jun 15;83(12):6334-6353. doi: 10.1021/acs.joc.8b00540. Epub 2018 Jun 6.
J Org Chem. 2018.
PMID: 29790748
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Nonsteroidal 2,3-dihydroquinoline glucocorticoid receptor agonists with reduced PEPCK activation.
Hudson AR, Higuchi RI, Roach SL, Valdez LJ, Adams ME, Vassar A, Rungta D, Syka PM, Mais DE, Marschke KB, Zhi L.
Hudson AR, et al. Among authors: valdez lj.
Bioorg Med Chem Lett. 2011 Mar 15;21(6):1654-7. doi: 10.1016/j.bmcl.2011.01.104. Epub 2011 Jan 27.
Bioorg Med Chem Lett. 2011.
PMID: 21324689
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Synthesis and characterization of nonsteroidal glucocorticoid receptor modulators for multiple myeloma.
Hudson AR, Roach SL, Higuchi RI, Phillips DP, Bissonnette RP, Lamph WW, Yen J, Li Y, Adams ME, Valdez LJ, Vassar A, Cuervo C, Kallel EA, Gharbaoui CJ, Mais DE, Miner JN, Marschke KB, Rungta D, Negro-Vilar A, Zhi L.
Hudson AR, et al. Among authors: valdez lj.
J Med Chem. 2007 Sep 20;50(19):4699-709. doi: 10.1021/jm070370z. Epub 2007 Aug 17.
J Med Chem. 2007.
PMID: 17705362
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