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Design, synthesis, and evaluation of substituted alkylindoles that activate G protein-coupled receptors distinct from the cannabinoid CB1 and CB2 receptors.
Kline T, Xu C, Kreitzer FR, Hurst DP, Eldeeb KM, Wager-Miller J, Olivas K, Hepburn SA, Huffman JW, Mackie K, Howlett AC, Reggio P, Stella N. Kline T, et al. Among authors: stella n. Eur J Med Chem. 2023 Mar 5;249:115123. doi: 10.1016/j.ejmech.2023.115123. Epub 2023 Jan 26. Eur J Med Chem. 2023. PMID: 36708677 Free PMC article.
Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype.
Nuechterlein N, Shelbourn A, Szulzewsky F, Arora S, Casad M, Pattwell S, Merino-Galan L, Sulman E, Arowa S, Alvinez N, Jung M, Brown D, Tang K, Jackson S, Stoica S, Chittaboina P, Banasavadi-Siddegowda YK, Wirsching HG, Stella N, Shapiro L, Paddison P, Patel AP, Gilbert MR, Abdullaev Z, Aldape K, Pratt D, Holland EC, Cimino PJ. Nuechterlein N, et al. Among authors: stella n. Genes Dev. 2024 Apr 17;38(5-6):273-288. doi: 10.1101/gad.351350.123. Genes Dev. 2024. PMID: 38589034
217 results