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Neutral Sphingomyelinase 2 Inhibition Limits Hepatic Steatosis and Inflammation.
Al-Rashed F, Arefanian H, Madhoun AA, Bahman F, Sindhu S, AlSaeed H, Jacob T, Thomas R, Al-Roub A, Alzaid F, Malik MDZ, Nizam R, Thanaraj TA, Al-Mulla F, Hannun YA, Ahmad R. Al-Rashed F, et al. Among authors: hannun ya. Cells. 2024 Mar 6;13(5):463. doi: 10.3390/cells13050463. Cells. 2024. PMID: 38474427 Free PMC article.
Expression of Ceramide Synthases in Mice and Their Roles in Regulating Acyl-Chain Sphingolipids: A Framework for Baseline Levels and Future Implications in Aging and Disease.
Richardson WJ, Humphrey SB, Sears SM, Hoffman NA, Orwick AJ, Doll MA, Doll CL, Xia C, Hernandez-Corbacho M, Snider JM, Obeid LM, Hannun YA, Snider AJ, Siskind LJ. Richardson WJ, et al. Among authors: hannun ya. Mol Pharmacol. 2024 Feb 15;105(3):131-143. doi: 10.1124/molpharm.123.000788. Mol Pharmacol. 2024. PMID: 38164625 Free PMC article.
Targeting sphingosine kinase 1 in p53KO thymic lymphoma.
Velazquez FN, Stith JL, Zhang L, Allam AM, Haley J, Obeid LM, Snider AJ, Hannun YA. Velazquez FN, et al. Among authors: hannun ya. FASEB J. 2023 Nov;37(11):e23247. doi: 10.1096/fj.202301417R. FASEB J. 2023. PMID: 37800872
A novel HSPB1S139F mouse model of Charcot-Marie-Tooth Disease.
Espinoza KS, Hermanson KN, Beard CA, Schwartz NU, Snider JM, Low BE, Wiles MV, Hannun YA, Obeid LM, Snider AJ. Espinoza KS, et al. Among authors: hannun ya. Prostaglandins Other Lipid Mediat. 2023 Dec;169:106769. doi: 10.1016/j.prostaglandins.2023.106769. Epub 2023 Aug 23. Prostaglandins Other Lipid Mediat. 2023. PMID: 37625781
Ceramide as an endothelial cell surface receptor and a lung-specific lipid vascular target for circulating ligands.
Staquicini DI, Cardó-Vila M, Rotolo JA, Staquicini FI, Tang FHF, Smith TL, Ganju A, Schiavone C, Dogra P, Wang Z, Cristini V, Giordano RJ, Ozawa MG, Driessen WHP, Proneth B, Souza GR, Brinker LM, Noureddine A, Snider AJ, Canals D, Gelovani JG, Petrache I, Tuder RM, Obeid LM, Hannun YA, Kolesnick RN, Brinker CJ, Pasqualini R, Arap W. Staquicini DI, et al. Among authors: hannun ya. Proc Natl Acad Sci U S A. 2023 Aug 22;120(34):e2220269120. doi: 10.1073/pnas.2220269120. Epub 2023 Aug 14. Proc Natl Acad Sci U S A. 2023. PMID: 37579172 Free PMC article.
Neutral ceramidase-active site inhibitor chemotypes and binding modes.
Coant N, Bickel JD, Rahaim R, Otsuka Y, Choi YM, Xu R, Simoes M, Cariello C, Mao C, Saied EM, Arenz C, Spicer TP, Bannister TD, Tonge PJ, Airola MV, Scampavia L, Hannun YA, Rizzo RC, Haley JD. Coant N, et al. Among authors: hannun ya. Bioorg Chem. 2023 Oct;139:106747. doi: 10.1016/j.bioorg.2023.106747. Epub 2023 Jul 27. Bioorg Chem. 2023. PMID: 37531819 Free PMC article.
587 results