King FD - Search Results

1

N-[(1-butyl-4-piperidinyl)methyl]-3,4dihydro-2H-[1,3]oxazino[3,2- a]indole10-carboxamide hydrochloride: the first potent and selective 5-HT4 receptor antagonist amide with oral activity.

Gaster LM, Joiner GF, King FD, Wyman PA, Sutton JM, Bingham S, Ellis ES, Sanger GJ, Wardle KA. Gaster LM, et al. Among authors: king fd. J Med Chem. 1995 Nov 24;38(24):4760-3. doi: 10.1021/jm00024a002. J Med Chem. 1995. PMID: 7490724 No abstract available.

2

Benzotriazinones as "virtual ring" mimics of o-methoxybenzamides: novel and potent 5-HT3 receptor antagonists.

King FD, Dabbs S, Bermudez J, Sanger GJ. King FD, et al. J Med Chem. 1990 Nov;33(11):2942-4. doi: 10.1021/jm00173a002. J Med Chem. 1990. PMID: 2231593 No abstract available.

3

5-Hydroxytryptamine (5-HT3) receptor antagonists. 1. Indazole and indolizine-3-carboxylic acid derivatives.

Bermudez J, Fake CS, Joiner GF, Joiner KA, King FD, Miner WD, Sanger GJ. Bermudez J, et al. Among authors: king fd. J Med Chem. 1990 Jul;33(7):1924-9. doi: 10.1021/jm00169a016. J Med Chem. 1990. PMID: 2362270

4

(1-Butyl-4-piperidinyl)methyl 8-amino-7-chloro-1,4-benzodioxane-5-carboxylate hydrochloride: a highly potent and selective 5-HT4 receptor antagonist derived from metoclopramide.

Gaster LM, Jennings AJ, Joiner GF, King FD, Mulholland KR, Rahman SK, Starr S, Wyman PA, Wardle KA, Ellis ES, et al. Gaster LM, et al. Among authors: king fd. J Med Chem. 1993 Dec 10;36(25):4121-3. doi: 10.1021/jm00077a018. J Med Chem. 1993. PMID: 8258837 No abstract available.

5

Substituted benzamides with conformationally restricted side chains. 5. Azabicyclo[x.y.z] derivatives as 5-HT4 receptor agonists and gastric motility stimulants.

King FD, Hadley MS, Joiner KT, Martin RT, Sanger GJ, Smith DM, Smith GE, Smith P, Turner DH, Watts EA. King FD, et al. J Med Chem. 1993 Mar 19;36(6):683-9. doi: 10.1021/jm00058a004. J Med Chem. 1993. PMID: 8459397

6

(+/-) 3-Amino-6-carboxamido-1,2,3,4-tetrahydrocarbazole: a conformationally restricted analogue of 5-carboxamidotryptamine with selectivity for the serotonin 5-HT1D receptor.

King FD, Brown AM, Gaster LM, Kaumann AJ, Medhurst AD, Parker SG, Parsons AA, Patch TL, Raval P. King FD, et al. J Med Chem. 1993 Jun 25;36(13):1918-9. doi: 10.1021/jm00065a015. J Med Chem. 1993. PMID: 8515429 No abstract available.

7

Azabicyclic indole esters as potent 5-HT4 receptor antagonists.

Wyman PA, Gaster LM, King FD, Sutton JM, Ellis ES, Wardle KA, Young TJ. Wyman PA, et al. Among authors: king fd. Bioorg Med Chem. 1996 Feb;4(2):255-61. doi: 10.1016/0968-0896(96)00037-5. Bioorg Med Chem. 1996. PMID: 8814883

8

Serotonin 5-HT3 and 5-HT4 receptor antagonists.

Gaster LM, King FD. Gaster LM, et al. Among authors: king fd. Med Res Rev. 1997 Mar;17(2):163-214. doi: 10.1002/(sici)1098-1128(199703)17:2<163::aid-med2>3.0.co;2-y. Med Res Rev. 1997. PMID: 9057164 Review. No abstract available.

9

The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo.

Gaster LM, Blaney FE, Davies S, Duckworth DM, Ham P, Jenkins S, Jennings AJ, Joiner GF, King FD, Mulholland KR, Wyman PA, Hagan JJ, Hatcher J, Jones BJ, Middlemiss DN, Price GW, Riley G, Roberts C, Routledge C, Selkirk J, Slade PD. Gaster LM, et al. Among authors: king fd. J Med Chem. 1998 Apr 9;41(8):1218-35. doi: 10.1021/jm970457s. J Med Chem. 1998. PMID: 9548813

10

Novel and selective 5-HT2C/2B receptor antagonists as potential anxiolytic agents: synthesis, quantitative structure-activity relationships, and molecular modeling of substituted 1-(3-pyridylcarbamoyl)indolines.

Bromidge SM, Dabbs S, Davies DT, Duckworth DM, Forbes IT, Ham P, Jones GE, King FD, Saunders DV, Starr S, Thewlis KM, Wyman PA, Blaney FE, Naylor CB, Bailey F, Blackburn TP, Holland V, Kennett GA, Riley GJ, Wood MD. Bromidge SM, et al. Among authors: king fd. J Med Chem. 1998 May 7;41(10):1598-612. doi: 10.1021/jm970741j. J Med Chem. 1998. PMID: 9572885

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