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Page 1
MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products.
Duncia JV, Santella JB 3rd, Higley CA, Pitts WJ, Wityak J, Frietze WE, Rankin FW, Sun JH, Earl RA, Tabaka AC, Teleha CA, Blom KF, Favata MF, Manos EJ, Daulerio AJ, Stradley DA, Horiuchi K, Copeland RA, Scherle PA, Trzaskos JM, Magolda RL, Trainor GL, Wexler RR, Hobbs FW, Olson RE. Duncia JV, et al. Among authors: trzaskos jm. Bioorg Med Chem Lett. 1998 Oct 20;8(20):2839-44. doi: 10.1016/s0960-894x(98)00522-8. Bioorg Med Chem Lett. 1998. PMID: 9873633
Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo.
Xue CB, Voss ME, Nelson DJ, Duan JJ, Cherney RJ, Jacobson IC, He X, Roderick J, Chen L, Corbett RL, Wang L, Meyer DT, Kennedy K, DeGradodagger WF, Hardman KD, Teleha CA, Jaffee BD, Liu RQ, Copeland RA, Covington MB, Christ DD, Trzaskos JM, Newton RC, Magolda RL, Wexler RR, Decicco CP. Xue CB, et al. Among authors: trzaskos jm. J Med Chem. 2001 Aug 2;44(16):2636-60. doi: 10.1021/jm010127e. J Med Chem. 2001. PMID: 11472217
Discovery of macrocyclic hydroxamic acids containing biphenylmethyl derivatives at P1', a series of selective TNF-alpha converting enzyme inhibitors with potent cellular activity in the inhibition of TNF-alpha release.
Xue CB, He X, Corbett RL, Roderick J, Wasserman ZR, Liu RQ, Jaffee BD, Covington MB, Qian M, Trzaskos JM, Newton RC, Magolda RL, Wexler RR, Decicco CP. Xue CB, et al. Among authors: trzaskos jm. J Med Chem. 2001 Oct 11;44(21):3351-4. doi: 10.1021/jm0155502. J Med Chem. 2001. PMID: 11585440
Sultam hydroxamates as novel matrix metalloproteinase inhibitors.
Cherney RJ, Mo R, Meyer DT, Hardman KD, Liu RQ, Covington MB, Qian M, Wasserman ZR, Christ DD, Trzaskos JM, Newton RC, Decicco CP. Cherney RJ, et al. Among authors: trzaskos jm. J Med Chem. 2004 Jun 3;47(12):2981-3. doi: 10.1021/jm049833g. J Med Chem. 2004. PMID: 15163180
Synthesis and structure-activity relationship of a novel, achiral series of TNF-alpha converting enzyme inhibitors.
Gilmore JL, King BW, Harris C, Maduskuie T, Mercer SE, Liu RQ, Covington MB, Qian M, Ribadeneria MD, Vaddi K, Trzaskos JM, Newton RC, Decicco CP, Duan JJ. Gilmore JL, et al. Among authors: trzaskos jm. Bioorg Med Chem Lett. 2006 May 15;16(10):2699-704. doi: 10.1016/j.bmcl.2006.02.015. Epub 2006 Mar 3. Bioorg Med Chem Lett. 2006. PMID: 16516466
95 results