Baccanari DP - Search Results

1

Selective inhibitors of Candida albicans dihydrofolate reductase: activity and selectivity of 5-(arylthio)-2,4-diaminoquinazolines.

Chan JH, Hong JS, Kuyper LF, Baccanari DP, Joyner SS, Tansik RL, Boytos CM, Rudolph SK. Chan JH, et al. Among authors: baccanari dp. J Med Chem. 1995 Sep 1;38(18):3608-16. doi: 10.1021/jm00018a021. J Med Chem. 1995. PMID: 7658448

2

Characterization of Candida albicans dihydrofolate reductase.

Baccanari DP, Tansik RL, Joyner SS, Fling ME, Smith PL, Freisheim JH. Baccanari DP, et al. J Biol Chem. 1989 Jan 15;264(2):1100-7. J Biol Chem. 1989. PMID: 2642898 Free article.

3

Substrate-inhibitor cooperative interactions with microbial dihydrofolate reductases.

Baccanari DP, Tansik RL, Hitchings GH. Baccanari DP, et al. Adv Enzyme Regul. 1987;26:3-15. doi: 10.1016/0065-2571(87)90003-3. Adv Enzyme Regul. 1987. PMID: 3314400

4

Inhibition of uridine phosphorylase: synthesis and structure-activity relationships of aryl-substituted 5-benzyluracils and 1-[(2-hydroxyethoxy)methyl]-5-benzyluracils.

Orr GF, Musso DL, Boswell GE, Kelley JL, Joyner SS, Davis ST, Baccanari DP. Orr GF, et al. Among authors: baccanari dp. J Med Chem. 1995 Sep 15;38(19):3850-6. doi: 10.1021/jm00019a015. J Med Chem. 1995. PMID: 7562916

5

Basis of selectivity of antibacterial diaminopyrimidines.

Baccanari DP, Kuyper LF. Baccanari DP, et al. J Chemother. 1993 Dec;5(6):393-9. J Chemother. 1993. PMID: 8195830 Review.

6

High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size.

Kuyper LF, Baccanari DP, Jones ML, Hunter RN, Tansik RL, Joyner SS, Boytos CM, Rudolph SK, Knick V, Wilson HR, Caddell JM, Friedman HS, Comley JC, Stables JN. Kuyper LF, et al. Among authors: baccanari dp. J Med Chem. 1996 Feb 16;39(4):892-903. doi: 10.1021/jm9505122. J Med Chem. 1996. PMID: 8632413

7

Pyrrolo[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines as conformationally restricted analogues of the antibacterial agent trimethoprim.

Kuyper LF, Garvey JM, Baccanari DP, Champness JN, Stammers DK, Beddell CR. Kuyper LF, et al. Among authors: baccanari dp. Bioorg Med Chem. 1996 Apr;4(4):593-602. doi: 10.1016/0968-0896(96)00045-4. Bioorg Med Chem. 1996. PMID: 8735847

8

Inhibition of uridine phosphorylase. Synthesis and structure-activity relationships of aryl-substituted 1-((2-hydroxyethoxy)methyl)-5-(3-phenoxybenzyl)uracil.

Orr GF, Musso DL, Kelley JL, Joyner SS, Davis ST, Baccanari DP. Orr GF, et al. Among authors: baccanari dp. J Med Chem. 1997 Apr 11;40(8):1179-85. doi: 10.1021/jm960688j. J Med Chem. 1997. PMID: 9111291

9

X-Ray crystal structures of Candida albicans dihydrofolate reductase: high resolution ternary complexes in which the dihydronicotinamide moiety of NADPH is displaced by an inhibitor.

Whitlow M, Howard AJ, Stewart D, Hardman KD, Chan JH, Baccanari DP, Tansik RL, Hong JS, Kuyper LF. Whitlow M, et al. Among authors: baccanari dp. J Med Chem. 2001 Aug 30;44(18):2928-32. doi: 10.1021/jm0101444. J Med Chem. 2001. PMID: 11520201

10

Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogues.

Kuyper LF, Roth B, Baccanari DP, Ferone R, Beddell CR, Champness JN, Stammers DK, Dann JG, Norrington FE, Baker DJ, et al. Kuyper LF, et al. Among authors: baccanari dp. J Med Chem. 1985 Mar;28(3):303-11. doi: 10.1021/jm00381a008. J Med Chem. 1985. PMID: 3973902

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