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The polyoxyethylene castor oil Cremophor EL modifies multidrug resistance.
Schuurhuis GJ, Broxterman HJ, Pinedo HM, van Heijningen TH, van Kalken CK, Vermorken JB, Spoelstra EC, Lankelma J. Schuurhuis GJ, et al. Among authors: van heijningen th. Br J Cancer. 1990 Oct;62(4):591-4. doi: 10.1038/bjc.1990.335. Br J Cancer. 1990. PMID: 2223576 Free PMC article. No abstract available.
Changes in subcellular doxorubicin distribution and cellular accumulation alone can largely account for doxorubicin resistance in SW-1573 lung cancer and MCF-7 breast cancer multidrug resistant tumour cells.
Schuurhuis GJ, van Heijningen TH, Cervantes A, Pinedo HM, de Lange JH, Keizer HG, Broxterman HJ, Baak JP, Lankelma J. Schuurhuis GJ, et al. Among authors: van heijningen th. Br J Cancer. 1993 Nov;68(5):898-908. doi: 10.1038/bjc.1993.452. Br J Cancer. 1993. PMID: 8105865 Free PMC article.
Functional multidrug resistance phenotype associated with combined overexpression of Pgp/MDR1 and MRP together with 1-beta-D-arabinofuranosylcytosine sensitivity may predict clinical response in acute myeloid leukemia.
Schuurhuis GJ, Broxterman HJ, Ossenkoppele GJ, Baak JP, Eekman CA, Kuiper CM, Feller N, van Heijningen TH, Klumper E, Pieters R, et al. Schuurhuis GJ, et al. Among authors: van heijningen th. Clin Cancer Res. 1995 Jan;1(1):81-93. Clin Cancer Res. 1995. PMID: 9815890