Gould RJ - Search Results

1

Platelet aggregation monitored in a 96 well microplate reader is useful for evaluation of platelet agonists and antagonists.

Bednar B, Condra C, Gould RJ, Connolly TM. Bednar B, et al. Among authors: gould rj. Thromb Res. 1995 Mar 1;77(5):453-63. doi: 10.1016/0049-3848(95)93881-y. Thromb Res. 1995. PMID: 7778060

2

Discovery and initial structure-activity relationships of trisubstituted ureas as thrombin receptor (PAR-1) antagonists.

Barrow JC, Nantermet PG, Selnick HG, Glass KL, Ngo PL, Young MB, Pellicore JM, Breslin MJ, Hutchinson JH, Freidinger RM, Condra C, Karczewski J, Bednar RA, Gaul SL, Stern A, Gould R, Connolly TM. Barrow JC, et al. Bioorg Med Chem Lett. 2001 Oct 22;11(20):2691-6. doi: 10.1016/s0960-894x(01)00538-8. Bioorg Med Chem Lett. 2001. PMID: 11591503

3

Recombinant leech antiplatelet protein prevents collagen-mediated platelet aggregation but not collagen graft thrombosis in baboons.

Schaffer LW, Davidson JT, Siegl PK, Gould RJ, Nutt RF, Brady SF, Connolly TM. Schaffer LW, et al. Among authors: gould rj. Arterioscler Thromb. 1993 Nov;13(11):1593-601. doi: 10.1161/01.atv.13.11.1593. Arterioscler Thromb. 1993. PMID: 8218100

4

An antibody against the exosite of the cloned thrombin receptor inhibits experimental arterial thrombosis in the African green monkey.

Cook JJ, Sitko GR, Bednar B, Condra C, Mellott MJ, Feng DM, Nutt RF, Shafer JA, Gould RJ, Connolly TM. Cook JJ, et al. Among authors: gould rj. Circulation. 1995 Jun 15;91(12):2961-71. doi: 10.1161/01.cir.91.12.2961. Circulation. 1995. PMID: 7796507

5

Species variability in platelet and other cellular responsiveness to thrombin receptor-derived peptides.

Connolly TM, Condra C, Feng DM, Cook JJ, Stranieri MT, Reilly CF, Nutt RF, Gould RJ. Connolly TM, et al. Among authors: gould rj. Thromb Haemost. 1994 Oct;72(4):627-33. Thromb Haemost. 1994. PMID: 7878643

6

Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1).

Nantermet PG, Barrow JC, Lundell GF, Pellicore JM, Rittle KE, Young M, Freidinger RM, Connolly TM, Condra C, Karczewski J, Bednar RA, Gaul SL, Gould RJ, Prendergast K, Selnick HG. Nantermet PG, et al. Among authors: gould rj. Bioorg Med Chem Lett. 2002 Feb 11;12(3):319-23. doi: 10.1016/s0960-894x(01)00745-4. Bioorg Med Chem Lett. 2002. PMID: 11814787

7

Non-peptide glycoprotein IIb/IIIa inhibitors. 17. Design and synthesis of orally active, long-acting non-peptide fibrinogen receptor antagonists.

Askew BC, Bednar RA, Bednar B, Claremon DA, Cook JJ, McIntyre CJ, Hunt CA, Gould RJ, Lynch RJ, Lynch JJ Jr, Gaul SL, Stranieri MT, Sitko GR, Holahan MA, Glass JD, Hamill T, Gorham LM, Prueksaritanont T, Baldwin JJ, Hartman GD. Askew BC, et al. Among authors: gould rj. J Med Chem. 1997 Jun 6;40(12):1779-88. doi: 10.1021/jm9608117. J Med Chem. 1997. PMID: 9191954

8

Identification of low molecular weight GP IIb/IIIa antagonists that bind preferentially to activated platelets.

Bednar RA, Gaul SL, Hamill TG, Egbertson MS, Shafer JA, Hartman GD, Gould RJ, Bednar B. Bednar RA, et al. Among authors: gould rj. J Pharmacol Exp Ther. 1998 Jun;285(3):1317-26. J Pharmacol Exp Ther. 1998. PMID: 9618439

9

Non-peptide GPIIb/IIIa inhibitors. 20. Centrally constrained thienothiophene alpha-sulfonamides are potent, long acting in vivo inhibitors of platelet aggregation.

Egbertson MS, Cook JJ, Bednar B, Prugh JD, Bednar RA, Gaul SL, Gould RJ, Hartman GD, Homnick CF, Holahan MA, Libby LA, Lynch JJ Jr, Lynch RJ, Sitko GR, Stranieri MT, Vassallo LM. Egbertson MS, et al. Among authors: gould rj. J Med Chem. 1999 Jul 1;42(13):2409-21. doi: 10.1021/jm980722p. J Med Chem. 1999. PMID: 10395482

10

Flow cytometric measurement of kinetic and equilibrium binding parameters of arginine-glycine-aspartic acid ligands in binding to glycoprotein IIb/IIIa on platelets.

Bednar B, Cunningham ME, McQueney PA, Egbertson MS, Askew BC, Bednar RA, Hartman GD, Gould RJ. Bednar B, et al. Among authors: gould rj. Cytometry. 1997 May 1;28(1):58-65. doi: 10.1002/(sici)1097-0320(19970501)28:1<58::aid-cyto7>3.0.co;2-d. Cytometry. 1997. PMID: 9136756 Free article.

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