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Signaling-competent receptor chimeras allow mapping of major insulin receptor binding domain determinants.
Schumacher R, Soos MA, Schlessinger J, Brandenburg D, Siddle K, Ullrich A. Schumacher R, et al. Among authors: ullrich a. J Biol Chem. 1993 Jan 15;268(2):1087-94. J Biol Chem. 1993. PMID: 7678247 Free article.
In addition, both the IGF-1R/IR C3' chimera and another chimera (C13') displayed high affinity binding properties for IGF-1, which suggests distinct locations for major insulin and IGF-1 binding determinants in their respective receptors, in agreement with our previous findings ( …
In addition, both the IGF-1R/IR C3' chimera and another chimera (C13') displayed high affinity binding properties for IGF-1, which suggests …
746 results