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Page 1
Heteroaryl-fused 2-phenylisothiazolone inhibitors of cartilage breakdown.
Wright SW, Petraitis JJ, Abelman MM, Batt DG, Bostrom LL, Corbett RL, Decicco CP, Di Meo SV, Freimark B, Giannaras JV, et al. Wright SW, et al. Among authors: decicco cp. J Med Chem. 1994 Sep 16;37(19):3071-8. doi: 10.1021/jm00045a012. J Med Chem. 1994. PMID: 7932530
Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo.
Xue CB, Voss ME, Nelson DJ, Duan JJ, Cherney RJ, Jacobson IC, He X, Roderick J, Chen L, Corbett RL, Wang L, Meyer DT, Kennedy K, DeGradodagger WF, Hardman KD, Teleha CA, Jaffee BD, Liu RQ, Copeland RA, Covington MB, Christ DD, Trzaskos JM, Newton RC, Magolda RL, Wexler RR, Decicco CP. Xue CB, et al. Among authors: decicco cp. J Med Chem. 2001 Aug 2;44(16):2636-60. doi: 10.1021/jm010127e. J Med Chem. 2001. PMID: 11472217
Discovery of macrocyclic hydroxamic acids containing biphenylmethyl derivatives at P1', a series of selective TNF-alpha converting enzyme inhibitors with potent cellular activity in the inhibition of TNF-alpha release.
Xue CB, He X, Corbett RL, Roderick J, Wasserman ZR, Liu RQ, Jaffee BD, Covington MB, Qian M, Trzaskos JM, Newton RC, Magolda RL, Wexler RR, Decicco CP. Xue CB, et al. Among authors: decicco cp. J Med Chem. 2001 Oct 11;44(21):3351-4. doi: 10.1021/jm0155502. J Med Chem. 2001. PMID: 11585440
Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-alpha converting enzyme inhibitors. Part 1: lead identification.
Xue CB, He X, Roderick J, Corbett RL, Duan JJ, Liu RQ, Covington MB, Newton RC, Trzaskos JM, Magolda RL, Wexler RR, Decicco CP. Xue CB, et al. Among authors: decicco cp. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4293-7. doi: 10.1016/j.bmcl.2003.09.056. Bioorg Med Chem Lett. 2003. PMID: 14643312
Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-alpha converting enzyme inhibitors. Part 2: lead optimization.
Xue CB, He X, Roderick J, Corbett RL, Duan JJ, Liu RQ, Covington MB, Qian M, Ribadeneira MD, Vaddi K, Christ DD, Newton RC, Trzaskos JM, Magolda RL, Wexler RR, Decicco CP. Xue CB, et al. Among authors: decicco cp. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4299-304. doi: 10.1016/j.bmcl.2003.09.057. Bioorg Med Chem Lett. 2003. PMID: 14643313
N-Arylalkylpiperidine urea derivatives as CC chemokine receptor-3 (CCR3) antagonists.
Batt DG, Houghton GC, Roderick J, Santella JB 3rd, Wacker DA, Welch PK, Orlovsky YI, Wadman EA, Trzaskos JM, Davies P, Decicco CP, Carter PH. Batt DG, et al. Among authors: decicco cp. Bioorg Med Chem Lett. 2005 Feb 1;15(3):787-91. doi: 10.1016/j.bmcl.2004.11.006. Bioorg Med Chem Lett. 2005. PMID: 15664858
CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity.
Pruitt JR, Batt DG, Wacker DA, Bostrom LL, Booker SK, McLaughlin E, Houghton GC, Varnes JG, Christ DD, Covington M, Das AM, Davies P, Graden D, Kariv I, Orlovsky Y, Stowell NC, Vaddi KG, Wadman EA, Welch PK, Yeleswaram S, Solomon KA, Newton RC, Decicco CP, Carter PH, Ko SS. Pruitt JR, et al. Among authors: decicco cp. Bioorg Med Chem Lett. 2007 Jun 1;17(11):2992-7. doi: 10.1016/j.bmcl.2007.03.065. Epub 2007 Mar 24. Bioorg Med Chem Lett. 2007. PMID: 17418570
A new 4-(2-methylquinolin-4-ylmethyl)phenyl P1' group for the beta-amino hydroxamic acid derived TACE inhibitors.
Chen XT, Ghavimi B, Corbett RL, Xue CB, Liu RQ, Covington MB, Qian M, Vaddi KG, Christ DD, Hartman KD, Ribadeneira MD, Trzaskos JM, Newton RC, Decicco CP, Duan JJ. Chen XT, et al. Among authors: decicco cp. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1865-70. doi: 10.1016/j.bmcl.2007.01.041. Epub 2007 Jan 24. Bioorg Med Chem Lett. 2007. PMID: 17276676
85 results