Smith EM - Search Results

1

Mercaptoacyl amino acid inhibitors of atriopeptidase. 1. Structure-activity relationship studies of methionine and S-alkylcysteine derivatives.

Neustadt BR, Smith EM, Nechuta TL, Bronnenkant AA, Haslanger MF, Watkins RW, Foster CJ, Sybertz EJ. Neustadt BR, et al. Among authors: smith em. J Med Chem. 1994 Jul 22;37(15):2461-76. doi: 10.1021/jm00041a026. J Med Chem. 1994. PMID: 8057292

2

Carboxyalkyl dipeptides with atrial natriuretic factor potentiating and antihypertensive activity.

Haslanger MF, Sybertz EJ, Neustadt BR, Smith EM, Nechuta TL, Berger J. Haslanger MF, et al. Among authors: smith em. J Med Chem. 1989 Apr;32(4):737-9. doi: 10.1021/jm00124a002. J Med Chem. 1989. PMID: 2522989 No abstract available.

3

Angiotensin converting enzyme inhibitors: spirapril and related compounds.

Smith EM, Swiss GF, Neustadt BR, McNamara P, Gold EH, Sybertz EJ, Baum T. Smith EM, et al. J Med Chem. 1989 Jul;32(7):1600-6. doi: 10.1021/jm00127a033. J Med Chem. 1989. PMID: 2544729

4

Synthesis and pharmacological activity of angiotensin converting enzyme inhibitors: N-(mercaptoacyl)-4-substituted-(S)-prolines.

Smith EM, Swiss GF, Neustadt BR, Gold EH, Sommer JA, Brown AD, Chiu PJ, Moran R, Sybertz EJ, Baum T. Smith EM, et al. J Med Chem. 1988 Apr;31(4):875-85. doi: 10.1021/jm00399a033. J Med Chem. 1988. PMID: 2832605

5

Atrial natriuretic factor potentiating and hemodynamic effects of SCH 42495, a new, neutral metalloendopeptidase inhibitor.

Watkins RW, Vemulapalli S, Chiu PJ, Foster C, Smith EM, Neustadt B, Haslanger M, Sybertz EJ. Watkins RW, et al. Among authors: smith em. Am J Hypertens. 1993 May;6(5 Pt 1):357-68. doi: 10.1093/ajh/6.5.357. Am J Hypertens. 1993. PMID: 8512660

6

Construction of a family of biphenyl combinatorial libraries: structure-activity studies utilizing libraries of mixtures.

Neustadt BR, Smith EM, Lindo N, Nechuta T, Bronnenkant A, Wu A, Armstrong L, Kumar C. Neustadt BR, et al. Among authors: smith em. Bioorg Med Chem Lett. 1998 Sep 8;8(17):2395-8. doi: 10.1016/s0960-894x(98)00433-8. Bioorg Med Chem Lett. 1998. PMID: 9873548

7

Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors.

Wang YS, Strickland C, Voigt JH, Kennedy ME, Beyer BM, Senior MM, Smith EM, Nechuta TL, Madison VS, Czarniecki M, McKittrick BA, Stamford AW, Parker EM, Hunter JC, Greenlee WJ, Wyss DF. Wang YS, et al. Among authors: smith em. J Med Chem. 2010 Feb 11;53(3):942-50. doi: 10.1021/jm901472u. J Med Chem. 2010. PMID: 20043700

8

2,6-Disubstituted N-arylsulfonyl piperidines as gamma-secretase inhibitors.

Pissarnitski DA, Asberom T, Bara TA, Buevich AV, Clader JW, Greenlee WJ, Guzik HS, Josien HB, Li W, McEwan M, McKittrick BA, Nechuta TL, Parker EM, Sinning L, Smith EM, Song L, Vaccaro HA, Voigt JH, Zhang L, Zhang Q, Zhao Z. Pissarnitski DA, et al. Among authors: smith em. Bioorg Med Chem Lett. 2007 Jan 1;17(1):57-62. doi: 10.1016/j.bmcl.2006.09.094. Epub 2006 Oct 4. Bioorg Med Chem Lett. 2007. PMID: 17055268

9

T-type calcium channel blockers: spiro-piperidine azetidines and azetidinones-optimization, design and synthesis.

Smith EM, Sorota S, Kim HM, McKittrick BA, Nechuta TL, Bennett C, Knutson C, Burnett DA, Kieselgof J, Tan Z, Rindgen D, Bridal T, Zhou X, Jia YP, Dong Z, Mullins D, Zhang X, Priestley T, Correll CC, Tulshian D, Czarniecki M, Greenlee WJ. Smith EM, et al. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4602-6. doi: 10.1016/j.bmcl.2010.06.012. Epub 2010 Jun 8. Bioorg Med Chem Lett. 2010. PMID: 20580233

10

Targeting integrins alpha v beta 3 and alpha v beta 5 for blocking tumor-induced angiogenesis.

Kumar CC, Armstrong L, Yin Z, Malkowski M, Maxwell E, Ling H, Yaremko B, Liu M, Varner J, Smith EM, Neustadt B, Nechuta T. Kumar CC, et al. Among authors: smith em. Adv Exp Med Biol. 2000;476:169-80. Adv Exp Med Biol. 2000. PMID: 10949664 Review. No abstract available.

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