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Antibody-enzyme conjugates for cancer therapy.
Melton RG, Sherwood RF. Melton RG, et al. J Natl Cancer Inst. 1996 Feb 21;88(3-4):153-65. doi: 10.1093/jnci/88.3-4.153. J Natl Cancer Inst. 1996. PMID: 8632489 Review.
The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--I. Purification and properties of a nitroreductase enzyme from Escherichia coli--a potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT).
Anlezark GM, Melton RG, Sherwood RF, Coles B, Friedlos F, Knox RJ. Anlezark GM, et al. Among authors: melton rg. Biochem Pharmacol. 1992 Dec 15;44(12):2289-95. doi: 10.1016/0006-2952(92)90671-5. Biochem Pharmacol. 1992. PMID: 1472094
Antibody directed enzyme prodrug therapy (ADEPT): clinical report.
Bagshawe KD, Sharma SK, Springer CJ, Antoniw P, Boden JA, Rogers GT, Burke PJ, Melton RG, Sherwood RF. Bagshawe KD, et al. Among authors: melton rg. Dis Markers. 1991 May-Aug;9(3-4):233-8. Dis Markers. 1991. PMID: 1813213 Clinical Trial.
A cytotoxic agent can be generated selectively at cancer sites.
Bagshawe KD, Springer CJ, Searle F, Antoniw P, Sharma SK, Melton RG, Sherwood RF. Bagshawe KD, et al. Among authors: melton rg. Br J Cancer. 1988 Dec;58(6):700-3. doi: 10.1038/bjc.1988.293. Br J Cancer. 1988. PMID: 3265633 Free PMC article.
The potential of carboxypeptidase G2-antibody conjugates as anti-tumour agents. I. Preparation of antihuman chorionic gonadotrophin-carboxypeptidase G2 and cytotoxicity of the conjugate against JAR choriocarcinoma cells in vitro.
Searle F, Bier C, Buckley RG, Newman S, Pedley RB, Bagshawe KD, Melton RG, Alwan SM, Sherwood RF. Searle F, et al. Among authors: melton rg. Br J Cancer. 1986 Mar;53(3):377-84. doi: 10.1038/bjc.1986.62. Br J Cancer. 1986. PMID: 3964540 Free PMC article.
45 results