Brinkmann U - Search Results

1

Role of CAS, a human homologue to the yeast chromosome segregation gene CSE1, in toxin and tumor necrosis factor mediated apoptosis.

Brinkmann U, Brinkmann E, Gallo M, Scherf U, Pastan I. Brinkmann U, et al. Among authors: brinkmann e. Biochemistry. 1996 May 28;35(21):6891-9. doi: 10.1021/bi952829+. Biochemistry. 1996. PMID: 8639641

We have previously isolated by expression/selection cloning plasmids containing human cDNAs that rendered MCF-7 breast cancer cells resistant to immunotoxins, Pseudomonas exotoxin (PE), and diphtheria toxin (DT) [Brinkmann et al. (1995) Mol. Med. 1, 206-216]. Here we descr …

We have previously isolated by expression/selection cloning plasmids containing human cDNAs that rendered MCF-7 breast cancer cells resistan …

2

A method for increasing the yield of properly folded recombinant fusion proteins: single-chain immunotoxins from renaturation of bacterial inclusion bodies.

Buchner J, Pastan I, Brinkmann U. Buchner J, et al. Among authors: brinkmann u. Anal Biochem. 1992 Sep;205(2):263-70. doi: 10.1016/0003-2697(92)90433-8. Anal Biochem. 1992. PMID: 1332541

3

Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1.

Brinkmann U, Brinkmann E, Gallo M, Pastan I. Brinkmann U, et al. Among authors: brinkmann e. Proc Natl Acad Sci U S A. 1995 Oct 24;92(22):10427-31. doi: 10.1073/pnas.92.22.10427. Proc Natl Acad Sci U S A. 1995. PMID: 7479798 Free PMC article.

4

Stabilization of the Fv fragments in recombinant immunotoxins by disulfide bonds engineered into conserved framework regions.

Reiter Y, Brinkmann U, Kreitman RJ, Jung SH, Lee B, Pastan I. Reiter Y, et al. Among authors: brinkmann u. Biochemistry. 1994 May 10;33(18):5451-9. doi: 10.1021/bi00184a014. Biochemistry. 1994. PMID: 7910034

We have recently described one example of a recombinant immunotoxin, B3(dsFv)-PE38KDEL, that is composed of such a dsFv connected to a truncated form of Pseudomonas exotoxin [Brinkmann, U., Reiter, Y., Jung, S.-H., Lee, B., & Pastan, I. (1993) Proc. Natl. Acad. …

We have recently described one example of a recombinant immunotoxin, B3(dsFv)-PE38KDEL, that is composed of such a dsFv connected to a trunc …

5

Expression cloning of cDNAs that render cancer cells resistant to Pseudomonas and diphtheria toxin and immunotoxins.

Brinkmann U, Brinkmann E, Pastan I. Brinkmann U, et al. Among authors: brinkmann e. Mol Med. 1995 Jan;1(2):206-16. Mol Med. 1995. PMID: 8529099 Free PMC article.

6

The human CAS protein which is homologous to the CSE1 yeast chromosome segregation gene product is associated with microtubules and mitotic spindle.

Scherf U, Pastan I, Willingham MC, Brinkmann U. Scherf U, et al. Among authors: brinkmann u. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2670-4. doi: 10.1073/pnas.93.7.2670. Proc Natl Acad Sci U S A. 1996. PMID: 8610099 Free PMC article.

7

The human CAS (cellular apoptosis susceptibility) gene mapping on chromosome 20q13 is amplified in BT474 breast cancer cells and part of aberrant chromosomes in breast and colon cancer cell lines.

Brinkmann U, Gallo M, Polymeropoulos MH, Pastan I. Brinkmann U, et al. Genome Res. 1996 Mar;6(3):187-94. doi: 10.1101/gr.6.3.187. Genome Res. 1996. PMID: 8963895 Free article.

8

Antisense inhibition of CAS, the human homologue of the yeast chromosome segregation gene CSE1, interferes with mitosis in HeLa cells.

Ogryzko VV, Brinkmann E, Howard BH, Pastan I, Brinkmann U. Ogryzko VV, et al. Among authors: brinkmann e, brinkmann u. Biochemistry. 1997 Aug 5;36(31):9493-500. doi: 10.1021/bi970236o. Biochemistry. 1997. PMID: 9235994

9

The hCSE1/CAS protein is phosphorylated by HeLa extracts and MEK-1: MEK-1 phosphorylation may modulate the intracellular localization of CAS.

Scherf U, Kalab P, Dasso M, Pastan I, Brinkmann U. Scherf U, et al. Among authors: brinkmann u. Biochem Biophys Res Commun. 1998 Sep 29;250(3):623-8. doi: 10.1006/bbrc.1998.9367. Biochem Biophys Res Commun. 1998. PMID: 9784396

10

Cytotoxic and antitumor activity of a recombinant tumor necrosis factor-B1(Fv) fusion protein on LeY antigen-expressing human cancer cells.

Scherf U, Benhar I, Webber KO, Pastan I, Brinkmann U. Scherf U, et al. Among authors: brinkmann u. Clin Cancer Res. 1996 Sep;2(9):1523-31. Clin Cancer Res. 1996. PMID: 9816329

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