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The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4.
Hughes B, Howat D, Lisle H, Holbrook M, James T, Gozzard N, Blease K, Hughes P, Kingaby R, Warrellow G, Alexander R, Head J, Boyd E, Eaton M, Perry M, Wales M, Smith B, Owens R, Catterall C, Lumb S, Russell A, Allen R, Merriman M, Bloxham D, Higgs G. Hughes B, et al. Among authors: warrellow g. Br J Pharmacol. 1996 Jul;118(5):1183-91. doi: 10.1111/j.1476-5381.1996.tb15522.x. Br J Pharmacol. 1996. PMID: 8818342 Free PMC article.
CDP840. A prototype of a novel class of orally active anti-inflammatory phosphodiesterase 4 inhibitors.
Alexander RP, Warrellow GJ, Eaton MA, Boyd EC, Head JC, Porter JR, Brown JA, Reuberson JT, Hutchinson B, Turner P, Boyce B, Barnes D, Mason B, Cannell A, Taylor RJ, Zomaya A, Millican A, Leonard J, Morphy R, Wales M, Perry M, Allen RA, Gozzard N, Hughes B, Higgs G. Alexander RP, et al. Among authors: warrellow gj. Bioorg Med Chem Lett. 2002 Jun 3;12(11):1451-6. doi: 10.1016/s0960-894x(02)00202-0. Bioorg Med Chem Lett. 2002. PMID: 12031318
Squaric acid derivatives as VLA-4 integrin antagonists.
Porter JR, Archibald SC, Childs K, Critchley D, Head JC, Linsley JM, Parton TA, Robinson MK, Shock A, Taylor RJ, Warrellow GJ, Alexander RP, Langham B. Porter JR, et al. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1051-4. doi: 10.1016/s0960-894x(02)00075-6. Bioorg Med Chem Lett. 2002. PMID: 11909715
Dehydrophenylalanine derivatives as VLA-4 integrin antagonists.
Porter JR, Archibald SC, Brown JA, Childs K, Critchley D, Head JC, Parton TA, Robinson MK, Shock A, Taylor RJ, Warrellow GJ. Porter JR, et al. Among authors: warrellow gj. Bioorg Med Chem Lett. 2003 Mar 10;13(5):805-8. doi: 10.1016/s0960-894x(03)00019-2. Bioorg Med Chem Lett. 2003. PMID: 12617895
16 results