Lee JC - Search Results

1

1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency.

Boehm JC, Smietana JM, Sorenson ME, Garigipati RS, Gallagher TF, Sheldrake PL, Bradbeer J, Badger AM, Laydon JT, Lee JC, Hillegass LM, Griswold DE, Breton JJ, Chabot-Fletcher MC, Adams JL. Boehm JC, et al. Among authors: lee jc. J Med Chem. 1996 Sep 27;39(20):3929-37. doi: 10.1021/jm960415o. J Med Chem. 1996. PMID: 8831759

2

Effects of pyridinyl imidazole compounds on murine TNF-alpha production.

Olivera DL, Laydon JT, Hillegass L, Badger AM, Lee JC. Olivera DL, et al. Among authors: lee jc. Agents Actions. 1993;39 Spec No:C55-7. doi: 10.1007/BF01972719. Agents Actions. 1993. PMID: 8273586

3

Evaluation of human cytokine production and effects of pharmacological agents in a heterologous system in vivo.

Griswold DE, Hillegass LM, O'Leary-Bartus J, Lee JC, Laydon JT, Torphy TJ. Griswold DE, et al. Among authors: lee jc. J Immunol Methods. 1996 Sep 9;195(1-2):1-5. doi: 10.1016/0022-1759(96)00054-3. J Immunol Methods. 1996. PMID: 8814313

4

Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function.

Badger AM, Bradbeer JN, Votta B, Lee JC, Adams JL, Griswold DE. Badger AM, et al. Among authors: lee jc. J Pharmacol Exp Ther. 1996 Dec;279(3):1453-61. J Pharmacol Exp Ther. 1996. PMID: 8968371

5

Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase.

Gallagher TF, Seibel GL, Kassis S, Laydon JT, Blumenthal MJ, Lee JC, Lee D, Boehm JC, Fier-Thompson SM, Abt JW, Soreson ME, Smietana JM, Hall RF, Garigipati RS, Bender PE, Erhard KF, Krog AJ, Hofmann GA, Sheldrake PL, McDonnell PC, Kumar S, Young PR, Adams JL. Gallagher TF, et al. Among authors: lee d, lee jc. Bioorg Med Chem. 1997 Jan;5(1):49-64. doi: 10.1016/s0968-0896(96)00212-x. Bioorg Med Chem. 1997. PMID: 9043657

6

Pyrimidinylimidazole inhibitors of CSBP/p38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes.

Adams JL, Boehm JC, Kassis S, Gorycki PD, Webb EF, Hall R, Sorenson M, Lee JC, Ayrton A, Griswold DE, Gallagher TF. Adams JL, et al. Among authors: lee jc. Bioorg Med Chem Lett. 1998 Nov 17;8(22):3111-6. doi: 10.1016/s0960-894x(98)00549-6. Bioorg Med Chem Lett. 1998. PMID: 9873686

7

Pyrimidinylimidazole inhibitors of p38: cyclic N-1 imidazole substituents enhance p38 kinase inhibition and oral activity.

Adams JL, Boehm JC, Gallagher TF, Kassis S, Webb EF, Hall R, Sorenson M, Garigipati R, Griswold DE, Lee JC. Adams JL, et al. Among authors: lee jc. Bioorg Med Chem Lett. 2001 Nov 5;11(21):2867-70. doi: 10.1016/s0960-894x(01)00570-4. Bioorg Med Chem Lett. 2001. PMID: 11597418

8

p38 MAP kinase: molecular target for the inhibition of pro-inflammatory cytokines.

Adams JL, Badger AM, Kumar S, Lee JC. Adams JL, et al. Among authors: lee jc. Prog Med Chem. 2001;38:1-60. doi: 10.1016/s0079-6468(08)70091-2. Prog Med Chem. 2001. PMID: 11774793 Review. No abstract available.

9

Pharmacology of the pyrroloimidazole, SK&F 105809--I. Inhibition of inflammatory cytokine production and of 5-lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid.

Marshall PJ, Griswold DE, Breton J, Webb EF, Hillegass LM, Sarau HM, Newton J Jr, Lee JC, Bender PE, Hanna N. Marshall PJ, et al. Among authors: lee jc. Biochem Pharmacol. 1991 Jul 25;42(4):813-24. doi: 10.1016/0006-2952(91)90041-3. Biochem Pharmacol. 1991. PMID: 1907824

10

N-Phenyl-N-purin-6-yl ureas: the design and synthesis of p38alpha MAP kinase inhibitors.

Wan Z, Boehm JC, Bower MJ, Kassis S, Lee JC, Zhao B, Adams JL. Wan Z, et al. Among authors: lee jc. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1191-4. doi: 10.1016/s0960-894x(03)00048-9. Bioorg Med Chem Lett. 2003. PMID: 12643941

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