Eculizumab dose tapering should take into account the nonlinearity of its pharmacokinetics.
Le Tilly O, Gatault P, Semlali S, Sberro-Soussan R, Passot C, Bertrand D, Desvignes C, Caillard S, Paintaud G, Halimi JM, Ternant D.
Le Tilly O, et al.
Br J Clin Pharmacol. 2024 May;90(5):1312-1321. doi: 10.1111/bcp.16019. Epub 2024 Feb 19.
Br J Clin Pharmacol. 2024.
PMID: 38373846
METHODS: We analysed 377 eculizumab serum concentrations from 44 patients treated for atypical haemolytic uraemic syndrome and C3 glomerulopathy with a population pharmacokinetic approach. Critical concentrations (below which a non-log-linear decline of concentration over …
METHODS: We analysed 377 eculizumab serum concentrations from 44 patients treated for atypical haemolytic uraemic syndrome and C3 glo …