Penning TD - Search Results

1

Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).

Penning TD, Talley JJ, Bertenshaw SR, Carter JS, Collins PW, Docter S, Graneto MJ, Lee LF, Malecha JW, Miyashiro JM, Rogers RS, Rogier DJ, Yu SS, AndersonGD, Burton EG, Cogburn JN, Gregory SA, Koboldt CM, Perkins WE, Seibert K, Veenhuizen AW, Zhang YY, Isakson PC. Penning TD, et al. J Med Chem. 1997 Apr 25;40(9):1347-65. doi: 10.1021/jm960803q. J Med Chem. 1997. PMID: 9135032

2

12(R)-hydroxyeicosatetraenoic acid is a neutrophil chemoattractant in the cavine, lapine, murine and canine dermis.

Fretland DJ, Widomski DL, Zemaitis JM, Tsai BS, Djuric SW, Penning TD, Miyashiro JM, Bauer RF. Fretland DJ, et al. Among authors: penning td. Prostaglandins Leukot Essent Fatty Acids. 1989 Aug;37(2):79-81. doi: 10.1016/0952-3278(89)90102-6. Prostaglandins Leukot Essent Fatty Acids. 1989. PMID: 2550970

3

SC-41930 inhibits neutrophil infiltration of the cavine dermis induced by 12(R)-hydroxyeicosatetraenoic acid.

Fretland DJ, Widomski DL, Shone RL, Penning TD, Miyashiro JM, Djuric SW. Fretland DJ, et al. Among authors: penning td. Prostaglandins Leukot Essent Fatty Acids. 1989 Dec;38(3):169-72. doi: 10.1016/0952-3278(89)90067-7. Prostaglandins Leukot Essent Fatty Acids. 1989. PMID: 2560200

4

Antiinflammatory effects of second-generation leukotriene B4 receptor antagonist, SC-53228: impact upon leukotriene B4- and 12(R)-HETE-mediated events.

Fretland DJ, Anglin CP, Bremer M, Isakson P, Widomski DL, Paulson SK, Docter SH, Djuric SW, Penning TD, Yu S, et al. Fretland DJ, et al. Among authors: penning td. Inflammation. 1995 Apr;19(2):193-205. doi: 10.1007/BF01534461. Inflammation. 1995. PMID: 7601505

5

Second-generation leukotriene B4 receptor antagonists related to SC-41930: heterocyclic replacement of the methyl ketone pharmacophore.

Penning TD, Djuric SW, Miyashiro JM, Yu S, Snyder JP, Spangler D, Anglin CP, Fretland DJ, Kachur JF, Keith RH, et al. Penning TD, et al. J Med Chem. 1995 Mar 17;38(6):858-68. doi: 10.1021/jm00006a002. J Med Chem. 1995. PMID: 7699700

6

The design and synthesis of second generation leukotriene B4 (LTB4) receptor antagonists related to SC-41930.

Penning TD, Djuric SW, Docter SH, Yu SS, Spangler D, Anglin CP, Fretland DJ, Kachur JF, Keith RH, Tsai BS, et al. Penning TD, et al. Agents Actions. 1993;39 Spec No:C11-3. doi: 10.1007/BF01972705. Agents Actions. 1993. PMID: 8273545

7

Leukotriene B4-induced granulocyte trafficking in guinea pig dermis. Effect of second-generation leukotriene B4 receptor antagonists, SC-50605 and SC-51146.

Fretland DJ, Widomski DL, Anglin CP, Penning TD, Yu S, Djuric SW. Fretland DJ, et al. Among authors: penning td. Inflammation. 1993 Jun;17(3):353-60. doi: 10.1007/BF00918996. Inflammation. 1993. PMID: 8392493

8

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents.

Kurumbail RG, Stevens AM, Gierse JK, McDonald JJ, Stegeman RA, Pak JY, Gildehaus D, Miyashiro JM, Penning TD, Seibert K, Isakson PC, Stallings WC. Kurumbail RG, et al. Among authors: penning td. Nature. 1996 Dec 19-26;384(6610):644-8. doi: 10.1038/384644a0. Nature. 1996. PMID: 8967954

9

Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors.

Carter JS, Kramer S, Talley JJ, Penning T, Collins P, Graneto MJ, Seibert K, Koboldt CM, Masferrer J, Zweifel B. Carter JS, et al. Bioorg Med Chem Lett. 1999 Apr 19;9(8):1171-4. doi: 10.1016/s0960-894x(99)00157-2. Bioorg Med Chem Lett. 1999. PMID: 10328307

10

Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase.

Penning TD, Chandrakumar NS, Chen BB, Chen HY, Desai BN, Djuric SW, Docter SH, Gasiecki AF, Haack RA, Miyashiro JM, Russell MA, Yu SS, Corley DG, Durley RC, Kilpatrick BF, Parnas BL, Askonas LJ, Gierse JK, Harding EI, Highkin MK, Kachur JF, Kim SH, Krivi GG, Villani-Price D, Pyla EY, Smith WG. Penning TD, et al. J Med Chem. 2000 Feb 24;43(4):721-35. doi: 10.1021/jm990496z. J Med Chem. 2000. PMID: 10691697

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