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The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo.
Gaster LM, Blaney FE, Davies S, Duckworth DM, Ham P, Jenkins S, Jennings AJ, Joiner GF, King FD, Mulholland KR, Wyman PA, Hagan JJ, Hatcher J, Jones BJ, Middlemiss DN, Price GW, Riley G, Roberts C, Routledge C, Selkirk J, Slade PD. Gaster LM, et al. Among authors: middlemiss dn. J Med Chem. 1998 Apr 9;41(8):1218-35. doi: 10.1021/jm970457s. J Med Chem. 1998. PMID: 9548813
[(3)H]-SB-269970--A selective antagonist radioligand for 5-HT(7) receptors.
Thomas DR, Atkinson PJ, Ho M, Bromidge SM, Lovell PJ, Villani AJ, Hagan JJ, Middlemiss DN, Price GW. Thomas DR, et al. Among authors: middlemiss dn. Br J Pharmacol. 2000 May;130(2):409-17. doi: 10.1038/sj.bjp.0703318. Br J Pharmacol. 2000. PMID: 10807680 Free PMC article.
Characterization of SB-269970-A, a selective 5-HT(7) receptor antagonist.
Hagan JJ, Price GW, Jeffrey P, Deeks NJ, Stean T, Piper D, Smith MI, Upton N, Medhurst AD, Middlemiss DN, Riley GJ, Lovell PJ, Bromidge SM, Thomas DR. Hagan JJ, et al. Among authors: middlemiss dn. Br J Pharmacol. 2000 Jun;130(3):539-48. doi: 10.1038/sj.bjp.0703357. Br J Pharmacol. 2000. PMID: 10821781 Free PMC article.
139 results