Mechanism of DNA-dependent protein kinase inhibition by cis-diamminedichloroplatinum(II)-damaged DNA.
Turchi JJ, Patrick SM, Henkels KM.
Turchi JJ, et al. Among authors: henkels km.
Biochemistry. 1997 Jun 17;36(24):7586-93. doi: 10.1021/bi963124q.
Biochemistry. 1997.
PMID: 9200710
Equilibrium binding and initial velocity experiments revealed a less than 2-fold increase in the Kd of Ku and the Km of DNA-PK for DNA containing a single 1,2-d(GpG) cisplatin adduct. The mechanism of DNA-PK inhibition by cisplatin-damaged DNA can be attributed to a large …
Equilibrium binding and initial velocity experiments revealed a less than 2-fold increase in the Kd of Ku and the Km of DNA-PK for DN …