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Insulin-mediated cell proliferation and survival involve inhibition of c-Jun N-terminal kinases through a phosphatidylinositol 3-kinase- and mitogen-activated protein kinase phosphatase-1-dependent pathway.
Desbois-Mouthon C, Cadoret A, Blivet-Van Eggelpoël MJ, Bertrand F, Caron M, Atfi A, Cherqui G, Capeau J. Desbois-Mouthon C, et al. Among authors: blivet van eggelpoel mj. Endocrinology. 2000 Mar;141(3):922-31. doi: 10.1210/endo.141.3.7390. Endocrinology. 2000. PMID: 10698166
Major circadian variations of glucose homeostasis in a patient with Rabson-Mendenhall syndrome and primary insulin resistance due to a mutation (Cys284-->Tyr) in the insulin receptor alpha-subunit.
Desbois-Mouthon C, Magré J, Duprey J, Caron M, Blivet-Van Eggelpoel MJ, Daubas C, Gourmelen M, Chevallier B, Rizkalla S, Robert JJ, Capeau J. Desbois-Mouthon C, et al. Pediatr Res. 1997 Jul;42(1):72-7. doi: 10.1203/00006450-199707000-00012. Pediatr Res. 1997. PMID: 9212040
Insulin-like growth factor-1 receptor inhibition induces a resistance mechanism via the epidermal growth factor receptor/HER3/AKT signaling pathway: rational basis for cotargeting insulin-like growth factor-1 receptor and epidermal growth factor receptor in hepatocellular carcinoma.
Desbois-Mouthon C, Baron A, Blivet-Van Eggelpoël MJ, Fartoux L, Venot C, Bladt F, Housset C, Rosmorduc O. Desbois-Mouthon C, et al. Among authors: blivet van eggelpoel mj. Clin Cancer Res. 2009 Sep 1;15(17):5445-56. doi: 10.1158/1078-0432.CCR-08-2980. Epub 2009 Aug 25. Clin Cancer Res. 2009. PMID: 19706799
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