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Age-related decrement in cytotoxic T lymphocyte (CTL) activity is associated with decreased levels of mRNA encoded by two CTL-associated serine esterase genes and the perforin gene in mice.
Bloom ET, Umehara H, Bleackley RC, Okumura K, Mostowski H, Babbitt JT. Bloom ET, et al. Eur J Immunol. 1990 Oct;20(10):2309-16. doi: 10.1002/eji.1830201021. Eur J Immunol. 1990. PMID: 2242759
Age-related alterations in several immunologic events have been suggested to be partly or completely responsible for this decline. We had previously demonstrated (Bloom et al., Cell. Immunol. 1988. 144: 440) in mice that a deterioration in the lytic mechanism may be …
Age-related alterations in several immunologic events have been suggested to be partly or completely responsible for this decline. We had pr …
109 results