Mehdi S - Search Results

1

Inhibition of human neutrophil elastase. 4. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of P2-modified, orally active peptidyl pentafluoroethyl ketones.

Cregge RJ, Durham SL, Farr RA, Gallion SL, Hare CM, Hoffman RV, Janusz MJ, Kim HO, Koehl JR, Mehdi S, Metz WA, Peet NP, Pelton JT, Schreuder HA, Sunder S, Tardif C. Cregge RJ, et al. Among authors: mehdi s. J Med Chem. 1998 Jul 2;41(14):2461-80. doi: 10.1021/jm970812e. J Med Chem. 1998. PMID: 9651152

2

Inhibition of human neutrophil elastase. 3. An orally active enol acetate prodrug.

Burkhart JP, Koehl JR, Mehdi S, Durham SL, Janusz MJ, Huber EW, Angelastro MR, Sunder S, Metz WA, Shum PW, et al. Burkhart JP, et al. Among authors: mehdi s. J Med Chem. 1995 Jan 20;38(2):223-33. doi: 10.1021/jm00002a003. J Med Chem. 1995. PMID: 7830264

3

Pharmacology of N-[4-(4-morpholinylcarbonyl)benzoyl]-L-valyl-N- [3,3,4,4,4-pentafluoro-1-(1-methylethyl)-2-oxobutyl]-L-prolinamide (MDL 101,146): a potent orally active inhibitor of human neutrophil elastase.

Durham SL, Hare CM, Angelastro MR, Burkhart JP, Koehl JR, Marquart AL, Mehdi S, Peet NP, Janusz MJ. Durham SL, et al. Among authors: mehdi s. J Pharmacol Exp Ther. 1994 Jul;270(1):185-91. J Pharmacol Exp Ther. 1994. PMID: 8035315

4

Preparation of alpha-keto ester enol acetates as potential prodrugs of human neutrophil elastase inhibitors.

Burkhart JP, Mehdi S, Koehl JR, Angelastro MR, Bey P, Peet NP. Burkhart JP, et al. Among authors: mehdi s. Bioorg Med Chem Lett. 1998 Jan 6;8(1):63-4. doi: 10.1016/s0960-894x(97)10184-6. Bioorg Med Chem Lett. 1998. PMID: 9871629

5

Synthesis of peptidyl fluoromethyl ketones and peptidyl alpha-keto esters as inhibitors of porcine pancreatic elastase, human neutrophil elastase, and rat and human neutrophil cathepsin G.

Peet NP, Burkhart JP, Angelastro MR, Giroux EL, Mehdi S, Bey P, Kolb M, Neises B, Schirlin D. Peet NP, et al. Among authors: mehdi s. J Med Chem. 1990 Jan;33(1):394-407. doi: 10.1021/jm00163a063. J Med Chem. 1990. PMID: 2296031

6

Application of a conformationally restricted Phe-Leu dipeptide mimetic to the design of a combined inhibitor of angiotensin I-converting enzyme and neutral endopeptidase 24.11.

Flynn GA, Beight DW, Mehdi S, Koehl JR, Giroux EL, French JF, Hake PW, Dage RC. Flynn GA, et al. Among authors: mehdi s. J Med Chem. 1993 Aug 6;36(16):2420-3. doi: 10.1021/jm00068a022. J Med Chem. 1993. PMID: 8360888 No abstract available.

7

Molecular design and characterization of an alpha-thrombin inhibitor containing a novel P1 moiety.

Malikayil JA, Burkhart JP, Schreuder HA, Broersma RJ Jr, Tardif C, Kutcher LW 3rd, Mehdi S, Schatzman GL, Neises B, Peet NP. Malikayil JA, et al. Among authors: mehdi s. Biochemistry. 1997 Feb 4;36(5):1034-40. doi: 10.1021/bi9622231. Biochemistry. 1997. PMID: 9033393

8

The synthesis of ketomethylene pseudopeptide analogues of dipeptide aldehyde inhibitors of calpain.

Angelastro MR, Marquart AL, Mehdi S, Koehl JR, Vaz RJ, Bey P, Peet NP. Angelastro MR, et al. Among authors: mehdi s. Bioorg Med Chem Lett. 1999 Jan 18;9(2):139-40. doi: 10.1016/s0960-894x(98)00704-5. Bioorg Med Chem Lett. 1999. PMID: 10021915

9

Hydroxyoxazolidines as alpha-aminoacetaldehye equivalents: novel inhibitors of calpain.

Peet NP, Kim HO, Marquart AL, Angelastro MR, Nieduzak TR, White JN, Friedrich D, Flynn GA, Webster ME, Vaz RJ, Linnik MD, Koehl JR, Mehdi S, Bey P, Emary B, Hwang KK. Peet NP, et al. Among authors: mehdi s. Bioorg Med Chem Lett. 1999 Aug 16;9(16):2365-70. doi: 10.1016/s0960-894x(99)00391-1. Bioorg Med Chem Lett. 1999. PMID: 10476870

10

Alpha-diketone and alpha-keto ester derivatives of N-protected amino acids and peptides as novel inhibitors of cysteine and serine proteinases.

Angelastro MR, Mehdi S, Burkhart JP, Peet NP, Bey P. Angelastro MR, et al. Among authors: mehdi s. J Med Chem. 1990 Jan;33(1):11-3. doi: 10.1021/jm00163a002. J Med Chem. 1990. PMID: 2296008 No abstract available.

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