Pike RN - Search Results

1

Antithrombins Wibble and Wobble (T85M/K): archetypal conformational diseases with in vivo latent-transition, thrombosis, and heparin activation.

Beauchamp NJ, Pike RN, Daly M, Butler L, Makris M, Dafforn TR, Zhou A, Fitton HL, Preston FE, Peake IR, Carrell RW. Beauchamp NJ, et al. Among authors: pike rn. Blood. 1998 Oct 15;92(8):2696-706. Blood. 1998. PMID: 9763552 Free article.

2

Introduction of a mutation in the shutter region of antithrombin (Phe77 --> Leu) increases affinity for heparin and decreases thermal stability.

Quinsey NS, Fitton HL, Coughlin P, Whisstock JC, Dafforn TR, Carrell RW, Bottomley SP, Pike RN. Quinsey NS, et al. Among authors: pike rn. Biochemistry. 2003 Sep 2;42(34):10169-73. doi: 10.1021/bi0349322. Biochemistry. 2003. PMID: 12939144

3

Mechanisms of antithrombin polymerisation and heparin activation probed by the insertion of synthetic reactive loop peptides.

Fitton HL, Pike RN, Carrell RW, Chang WS. Fitton HL, et al. Among authors: pike rn. Biol Chem. 1997 Sep;378(9):1059-63. doi: 10.1515/bchm.1997.378.9.1059. Biol Chem. 1997. PMID: 9348117 Free article.

4

The N-terminal segment of antithrombin acts as a steric gate for the binding of heparin.

Fitton HL, Skinner R, Dafforn TR, Jin L, Pike RN. Fitton HL, et al. Among authors: pike rn. Protein Sci. 1998 Mar;7(3):782-8. doi: 10.1002/pro.5560070328. Protein Sci. 1998. PMID: 9541411 Free PMC article.

5

Conformational changes in serpins: II. The mechanism of activation of antithrombin by heparin.

Whisstock JC, Pike RN, Jin L, Skinner R, Pei XY, Carrell RW, Lesk AM. Whisstock JC, et al. Among authors: pike rn. J Mol Biol. 2000 Sep 1;301(5):1287-305. doi: 10.1006/jmbi.2000.3982. J Mol Biol. 2000. PMID: 10966821

6

Heparin-dependent modification of the reactive center arginine of antithrombin and consequent increase in heparin binding affinity.

Pike RN, Potempa J, Skinner R, Fitton HL, McGraw WT, Travis J, Owen M, Jin L, Carrell RW. Pike RN, et al. J Biol Chem. 1997 Aug 8;272(32):19652-5. doi: 10.1074/jbc.272.32.19652. J Biol Chem. 1997. PMID: 9242619 Free article.

7

The anticoagulant activation of antithrombin by heparin.

Jin L, Abrahams JP, Skinner R, Petitou M, Pike RN, Carrell RW. Jin L, et al. Among authors: pike rn. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14683-8. doi: 10.1073/pnas.94.26.14683. Proc Natl Acad Sci U S A. 1997. PMID: 9405673 Free PMC article.

8

Physical characterization of serpin conformations.

Dafforn TR, Pike RN, Bottomley SP. Dafforn TR, et al. Among authors: pike rn. Methods. 2004 Feb;32(2):150-8. doi: 10.1016/s1046-2023(03)00206-8. Methods. 2004. PMID: 14698627

9

Angiotensinogen cleavage by renin: importance of a structurally constrained N-terminus.

Streatfeild-James RM, Williamson D, Pike RN, Tewksbury D, Carrell RW, Coughlin PB. Streatfeild-James RM, et al. Among authors: pike rn. FEBS Lett. 1998 Oct 2;436(2):267-70. doi: 10.1016/s0014-5793(98)01145-4. FEBS Lett. 1998. PMID: 9781693 Free article.

10

Activation of protease-activated receptors by gingipains from Porphyromonas gingivalis leads to platelet aggregation: a new trait in microbial pathogenicity.

Lourbakos A, Yuan YP, Jenkins AL, Travis J, Andrade-Gordon P, Santulli R, Potempa J, Pike RN. Lourbakos A, et al. Among authors: pike rn. Blood. 2001 Jun 15;97(12):3790-7. doi: 10.1182/blood.v97.12.3790. Blood. 2001. PMID: 11389018 Free article.

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