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1990 1
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Page 1
Production of pharmaceutical proteins by transgenic animals.
Houdebine LM. Houdebine LM. Comp Immunol Microbiol Infect Dis. 2009 Mar;32(2):107-21. doi: 10.1016/j.cimid.2007.11.005. Epub 2008 Feb 19. Comp Immunol Microbiol Infect Dis. 2009. PMID: 18243312 Free PMC article. Review.
Several transgenic animal species can produce recombinant proteins but presently two systems started being implemented. The first is milk from farm transgenic mammals which has been studied for 20 years and which allowed a protein, human antithrombin III, to …
Several transgenic animal species can produce recombinant proteins but presently two systems started being implemented. The first is …
Fibrinogen gamma' chain binds thrombin exosite II.
Lovely RS, Moaddel M, Farrell DH. Lovely RS, et al. J Thromb Haemost. 2003 Jan;1(1):124-31. doi: 10.1046/j.1538-7836.2003.00027.x. J Thromb Haemost. 2003. PMID: 12871549 Free article.
A high-affinity thrombin-binding site in an alternately processed fibrinogen variant, the gammaA/gamma' isoform, is characterized in this report. The binding site has been shown to be situated between gamma' 414 and 427, and Tyr418 and 422 in this part of the gam …
A high-affinity thrombin-binding site in an alternately processed fibrinogen variant, the gammaA/gamma' isoform, is characterized in …
Role of the gamma-carboxyglutamic acid domain of activated factor X in the presence of calcium during inhibition by antithrombin-heparin.
Whinna HC, Lesesky EB, Monroe DM, High KA, Larson PJ, Church FC. Whinna HC, et al. J Thromb Haemost. 2004 Jul;2(7):1127-34. doi: 10.1111/j.1538-7836.2004.00796.x. J Thromb Haemost. 2004. PMID: 15219196 Free article.
BACKGROUND: Factor (F)Xa has 11 gamma-carboxylated glutamic acid (Gla) residues that are involved in calcium-dependent membrane binding. ...Interestingly, three different effects were found with the recombinant FXa Gla-mutants for AT-heparin inhibition: (i) Gla--&gt …
BACKGROUND: Factor (F)Xa has 11 gamma-carboxylated glutamic acid (Gla) residues that are involved in calcium-dependent membrane bindi …
Thrombosis risk modification in transgenic mice containing the human fibrinogen thrombin-binding gamma' chain sequence.
Mosesson MW, Cooley BC, Hernandez I, Diorio JP, Weiler H. Mosesson MW, et al. J Thromb Haemost. 2009 Jan;7(1):102-10. doi: 10.1111/j.1538-7836.2008.03213.x. Epub 2008 Oct 30. J Thromb Haemost. 2009. PMID: 18983496 Free article.
BACKGROUND AND OBJECTIVES: Thrombin binding activity in murine fibrin (Antithrombin I) is restricted to its E domains inasmuch as murine gamma' chains (mu-gamma') do not bind thrombin. ...RESULTS: This procedure resulted in a murine fibrinogen species contain …
BACKGROUND AND OBJECTIVES: Thrombin binding activity in murine fibrin (Antithrombin I) is restricted to its E domains inasmuch as mur …
Anticoagulant activity of a sulfated galactan: serpin-independent effect and specific interaction with factor Xa.
Glauser BF, Rezende RM, Melo FR, Pereira MS, Francischetti IM, Monteiro RQ, Rezaie AR, Mourão PA. Glauser BF, et al. Thromb Haemost. 2009 Dec;102(6):1183-93. doi: 10.1160/TH09-04-0273. Thromb Haemost. 2009. PMID: 19967150 Free PMC article.
We also investigated the mechanism by which sulfated galactan promotes FXa inhibition by antithrombin using specific recombinant mutants of the protease. We show that sulfated galactan interacts with the heparin-binding exosite of FXa and Arg-236 and Lys-240 of this …
We also investigated the mechanism by which sulfated galactan promotes FXa inhibition by antithrombin using specific recombinant …
SAK-HV Triggered a Short-period Lipid-lowering Biotherapy Based on the Energy Model of Liver Proliferation via a Novel Pathway.
Zhang C, Huang Z, Jing H, Fu W, Yuan M, Xia W, Cai L, Gan X, Chen Y, Zou M, Long M, Wang J, Wang M, Xu D. Zhang C, et al. Theranostics. 2017 Apr 10;7(6):1749-1769. doi: 10.7150/thno.18415. eCollection 2017. Theranostics. 2017. PMID: 28529649 Free PMC article.
Both of them are components of metabolic syndrome that greatly threaten human health. Here, a recombinant fusion protein (SAK-HV) effectively treated NAFLD and hyperlipemia in high-fat-fed ApoE(-/-) mice, quails and rats within just 14 days. ...
Both of them are components of metabolic syndrome that greatly threaten human health. Here, a recombinant fusion protein (SAK-HV) eff …
Inhibition of factor VIIa-tissue factor coagulation activity by a hybrid protein.
Girard TJ, MacPhail LA, Likert KM, Novotny WF, Miletich JP, Broze GJ Jr. Girard TJ, et al. Science. 1990 Jun 15;248(4961):1421-4. doi: 10.1126/science.1972598. Science. 1990. PMID: 1972598
Lipoprotein-associated coagulation inhibitor (LACI) appears to inhibit tissue factor (TF)-induced blood coagulation by forming a quaternary inhibitory complex containing factor Xa, LACI, factor VIIa, and TF. A genetically engineered hybrid protein consisting of the light c …
Lipoprotein-associated coagulation inhibitor (LACI) appears to inhibit tissue factor (TF)-induced blood coagulation by forming a quaternary …
Structural requirements for tissue factor pathway inhibitor interactions with factor Xa and heparin.
Wesselschmidt R, Likert K, Huang Z, MacPhail L, Broze GJ Jr. Wesselschmidt R, et al. Blood Coagul Fibrinolysis. 1993 Oct;4(5):661-9. Blood Coagul Fibrinolysis. 1993. PMID: 8292716
Tissue factor pathway inhibitor (TFPI) is a multivalent Kunitz-type protease inhibitor, which inhibits factor Xa directly and in a factor Xa dependent manner inhibits the factor VIIa/tissue factor catalytic complex. Altered forms of recombinant TFPI (rTFPI) were tested for …
Tissue factor pathway inhibitor (TFPI) is a multivalent Kunitz-type protease inhibitor, which inhibits factor Xa directly and in a factor Xa …
Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor.
McNamara CA, Sarembock IJ, Gimple LW, Fenton JW 2nd, Coughlin SR, Owens GK. McNamara CA, et al. J Clin Invest. 1993 Jan;91(1):94-8. doi: 10.1172/JCI116206. J Clin Invest. 1993. PMID: 8380817 Free PMC article.
The present studies demonstrated that human alpha-thrombin was a potent and efficacious mitogen for cultured rat aortic SMC, stimulating an increase in 3H-thymidine incorporation, as well as an increase in cell number at 1 to 10 nM concentration. gamma-Thrombin, which is e …
The present studies demonstrated that human alpha-thrombin was a potent and efficacious mitogen for cultured rat aortic SMC, stimulating an …
Comparison of heparin- and dermatan sulfate-mediated catalysis of thrombin inactivation by heparin cofactor II.
Liaw PC, Austin RC, Fredenburgh JC, Stafford AR, Weitz JI. Liaw PC, et al. J Biol Chem. 1999 Sep 24;274(39):27597-604. doi: 10.1074/jbc.274.39.27597. J Biol Chem. 1999. PMID: 10488098 Free article.
The increased rate reflects displacement of the amino terminus of mutant D because (a) mutant D inactivates gamma-thrombin at a 65-fold slower rate than alpha-thrombin, (b) hirudin-(54-65) decreases the rate of thrombin inactivation, and (c) deletion of the amino terminus …
The increased rate reflects displacement of the amino terminus of mutant D because (a) mutant D inactivates gamma-thrombin at a 65-fo …
20 results