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Biotechnology and genetic engineering in the new drug development. Part I. DNA technology and recombinant proteins.
Stryjewska A, Kiepura K, Librowski T, Lochyński S. Stryjewska A, et al. Pharmacol Rep. 2013;65(5):1075-85. doi: 10.1016/s1734-1140(13)71466-x. Pharmacol Rep. 2013. PMID: 24399704 Free article. Review.
Powerful new instruments and biotechnology related scientific disciplines (genomics, proteomics) make it possible to examine and exploit the behavior of proteins and molecules. Recombinant DNA (rDNA) technologies (genetic, protein, and metabolic engineering) allow t …
Powerful new instruments and biotechnology related scientific disciplines (genomics, proteomics) make it possible to examine and exploit the …
Purification and Characterization of Recombinant Darbepoetin Alfa from Leishmania tarentolae.
Kianmehr A, Mahrooz A, Oladnabi M, Safdari Y, Ansari J, Veisi K, Evazalipour M, Shahbazmohammadi H, Omidinia E. Kianmehr A, et al. Mol Biotechnol. 2016 Sep;58(8-9):566-72. doi: 10.1007/s12033-016-9954-x. Mol Biotechnol. 2016. PMID: 27282622
We herein describe the structural characterization of recombinant darbepoetin alfa produced by Leishmania tarentolae T7-TR host. ...The structure of recombinant darbepoetin alfa was analyzed by isoelectric focusing, ultraviolet-visible sp …
We herein describe the structural characterization of recombinant darbepoetin alfa produced by Leishmania tarentolae T7 …
Erythropoietin and erythropoiesis stimulating agents.
Debeljak N, Sytkowski AJ. Debeljak N, et al. Drug Test Anal. 2012 Nov;4(11):805-12. doi: 10.1002/dta.1341. Epub 2012 Apr 16. Drug Test Anal. 2012. PMID: 22508651 Review.
Erythropoietin (EPO) is the main hormonal regulator of red blood cell production. Recombinant EPO has become the leading drug for treatment of anaemia from a variety of causes; however, it is sometimes misused in sport with the aim of improving performance and endurance. T …
Erythropoietin (EPO) is the main hormonal regulator of red blood cell production. Recombinant EPO has become the leading drug for tre …
Comparison of darbepoetin alfa and epoetin alfa in the management of anemia of critical illness.
Voils SA, Harpe SH, Brophy GM. Voils SA, et al. Pharmacotherapy. 2007 Apr;27(4):535-41. doi: 10.1592/phco.27.4.535. Pharmacotherapy. 2007. PMID: 17381380 Clinical Trial.
STUDY OBJECTIVE: To compare the effectiveness of darbepoetin alfa with epoetin alfa (recombinant human erythropoietin [rHuEPO]) for achieving transfusion independence and increasing hemoglobin concentrations in critically ill patients. ...Beginning a m …
STUDY OBJECTIVE: To compare the effectiveness of darbepoetin alfa with epoetin alfa (recombinant human erythropo …
Cloning and expression of codon-optimized recombinant darbepoetin alfa in Leishmania tarentolae T7-TR.
Kianmehr A, Golavar R, Rouintan M, Mahrooz A, Fard-Esfahani P, Oladnabi M, Khajeniazi S, Mostafavi SS, Omidinia E. Kianmehr A, et al. Protein Expr Purif. 2016 Feb;118:120-5. doi: 10.1016/j.pep.2015.10.013. Epub 2015 Nov 3. Protein Expr Purif. 2016. PMID: 26546410 Free article.
Darbepoetin alfa is an engineered and hyperglycosylated analog of recombinant human erythropoietin (EPO) which is used as a drug in treating anemia in patients with chronic kidney failure and cancer. This study desribes the secretory expression of a codon-opt …
Darbepoetin alfa is an engineered and hyperglycosylated analog of recombinant human erythropoietin (EPO) which is used …
Management of anaemia: a critical and systematic review of the cost effectiveness of erythropoiesis-stimulating agents.
Duh MS, Weiner JR, White LA, Lefebvre P, Greenberg PE. Duh MS, et al. Pharmacoeconomics. 2008;26(2):99-120. doi: 10.2165/00019053-200826020-00002. Pharmacoeconomics. 2008. PMID: 18198931 Review.
In general, this review of the literature suggests a cost advantage for epoetin alfa relative to darbepoetin alfa in the treatment of anaemia in renal and oncology indications. ...With the recent concerns about the safety of ESAs, especially when used outside …
In general, this review of the literature suggests a cost advantage for epoetin alfa relative to darbepoetin alfa in th …
Discovery and basic pharmacology of erythropoiesis-stimulating agents (ESAs), including the hyperglycosylated ESA, darbepoetin alfa: an update of the rationale and clinical impact.
Kiss Z, Elliott S, Jedynasty K, Tesar V, Szegedi J. Kiss Z, et al. Eur J Clin Pharmacol. 2010 Apr;66(4):331-40. doi: 10.1007/s00228-009-0780-y. Epub 2010 Feb 2. Eur J Clin Pharmacol. 2010. PMID: 20127232 Free article. Review.
Cloning of the human erythropoietin (EPO) gene and development of the first recombinant human erythropoietin (rHuEPO) drug were truly breakthroughs. ...Initial research focused on solving the problem of how the protein backbone could be engineered so a cell would add more …
Cloning of the human erythropoietin (EPO) gene and development of the first recombinant human erythropoietin (rHuEPO) drug were truly …
[Erythropoiesis stimulating agents].
Hoffmann M, Schwenger V. Hoffmann M, et al. Ther Umsch. 2011 Nov;68(11):650-4. doi: 10.1024/0040-5930/a000225. Ther Umsch. 2011. PMID: 22045527 German.
There are various products from different suppliers, which differ primarily in their production but not in their half-life or effectiveness. 2001 genetically modified darbepoetin alpha was launched, which is characterized by an approximately three times longer half- …
There are various products from different suppliers, which differ primarily in their production but not in their half-life or effectiveness. …
New anemia therapies: translating novel strategies from bench to bedside.
Macdougall IC. Macdougall IC. Am J Kidney Dis. 2012 Mar;59(3):444-51. doi: 10.1053/j.ajkd.2011.11.013. Epub 2011 Dec 21. Am J Kidney Dis. 2012. PMID: 22192713 Review.
Recombinant human erythropoietin (epoetin) has been available for the treatment of renal anemia for more than 20 years, and within the last decade two molecularly engineered analogues darbepoetin alfa and pegylated epoetin beta were introduced as longer-actin …
Recombinant human erythropoietin (epoetin) has been available for the treatment of renal anemia for more than 20 years, and within th …
Economic evaluation of weekly epoetin alfa versus biweekly darbepoetin alfa for chemotherapy-induced anaemia: evidence from a 16-week randomised trial.
Reed SD, Radeva JI, Daniel DB, Mody SH, Forlenza JB, McKenzie RS, Schulman KA. Reed SD, et al. Pharmacoeconomics. 2006;24(5):479-94. doi: 10.2165/00019053-200624050-00006. Pharmacoeconomics. 2006. PMID: 16706573 Clinical Trial.
There were no significant differences in the proportions of patients hospitalised (epoetin alfa 24.6%, darbepoetin alfa 22.0%; p = 0.57). Patients randomised to epoetin alfa experienced more inpatient days, on average, than patients randomised to da …
There were no significant differences in the proportions of patients hospitalised (epoetin alfa 24.6%, darbepoetin alfa …
39 results