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Opportunity and challenges of nasal powders: Drug formulation and delivery.
Tiozzo Fasiolo L, Manniello MD, Tratta E, Buttini F, Rossi A, Sonvico F, Bortolotti F, Russo P, Colombo G. Tiozzo Fasiolo L, et al. Eur J Pharm Sci. 2018 Feb 15;113:2-17. doi: 10.1016/j.ejps.2017.09.027. Epub 2017 Sep 20. Eur J Pharm Sci. 2018. PMID: 28942007 Review.
Despite the positive features, however, nasal products in this form still struggle to enter the market: the few available on the market are Onzetra Xsail (sumatriptan) for migraine relief and, for the treatment of rhinitis, Rhinocort Turbuhaler (budesonide), Teijin Rhinocort (bec …
Despite the positive features, however, nasal products in this form still struggle to enter the market: the few available on the market are …
Clinical pharmacology study of the corticosteroid nasal spray dexamethasone cipecilate (NS-126): examination of the durability of efficacy in the nasal induction test.
Gotoh M, Okubo K, Okuda M, Hamada C. Gotoh M, et al. Expert Opin Investig Drugs. 2010 Dec;19(12):1475-86. doi: 10.1517/13543784.2010.531258. Epub 2010 Nov 11. Expert Opin Investig Drugs. 2010. PMID: 21067470 Clinical Trial.
CONCLUSIONS: Dexamethasone cipecilate was shown to be a corticosteroid having sustainable local efficacy. The results suggest that once-daily administration of dexamethasone cipecilate is effective in patients with allergic rhinitis, and that its effic …
CONCLUSIONS: Dexamethasone cipecilate was shown to be a corticosteroid having sustainable local efficacy. The results suggest …
In vitro metabolism of dexamethasone cipecilate, a novel synthetic corticosteroid, in human liver and nasal mucosa.
Sasagawa T, Yamada T, Nakagawa T, Tsujioka T, Takahashi Y, Kawakita N, Nonaka K, Nakamura A. Sasagawa T, et al. Xenobiotica. 2011 Oct;41(10):874-84. doi: 10.3109/00498254.2011.582894. Epub 2011 Jun 10. Xenobiotica. 2011. PMID: 21657966
Dexamethasone cipecilate (DX-CP, 9-fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-cyclohexanecarboxylate 17-cyclopropanecarboxylate) is a novel synthetic corticosteroid used to treat allergic rhinitis. ...
Dexamethasone cipecilate (DX-CP, 9-fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-cyclohexanecarb …