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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 2
1999 3
2000 1
2001 4
2002 5
2003 5
2004 4
2005 7
2006 3
2007 8
2008 6
2009 10
2010 6
2011 5
2012 17
2013 11
2014 2
2015 7
2016 2
2017 6
2018 3
2019 4
2020 4
2021 4
2022 1
2023 4
2024 0

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112 results

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Page 1
Therapeutic Fc-fusion proteins: Current analytical strategies.
Duivelshof BL, Murisier A, Camperi J, Fekete S, Beck A, Guillarme D, D'Atri V. Duivelshof BL, et al. J Sep Sci. 2021 Jan;44(1):35-62. doi: 10.1002/jssc.202000765. Epub 2020 Sep 29. J Sep Sci. 2021. PMID: 32914936 Review.
Fc-Fusion proteins represent a successful class of biopharmaceutical products, with already 13 drugs approved in the European Union and United States as well as three biosimilar versions of etanercept. Fc-Fusion products combine tailored pharmacological properties of biolo …
Fc-Fusion proteins represent a successful class of biopharmaceutical products, with already 13 drugs approved in the European Union and Unit …
Strategies toward rheumatoid arthritis therapy; the old and the new.
Abbasi M, Mousavi MJ, Jamalzehi S, Alimohammadi R, Bezvan MH, Mohammadi H, Aslani S. Abbasi M, et al. J Cell Physiol. 2019 Jul;234(7):10018-10031. doi: 10.1002/jcp.27860. Epub 2018 Dec 7. J Cell Physiol. 2019. PMID: 30536757 Review.
The biological therapies, on the contrary, are chimeric anti-CD20 monoclonal antibody, rituximab, inhibitors of tumor necrosis factor-alpha (TNF-alpha) like etanercept, infliximab, and adalimumab, a recombinant inhibitor of interleukin-1 (IL-1), anakinra, and costim …
The biological therapies, on the contrary, are chimeric anti-CD20 monoclonal antibody, rituximab, inhibitors of tumor necrosis factor-alpha …
Etanercept for treating axial spondyloarthritis.
Guillot X, Prati C, Sondag M, Wendling D. Guillot X, et al. Expert Opin Biol Ther. 2017 Sep;17(9):1173-1181. doi: 10.1080/14712598.2017.1347156. Epub 2017 Jul 6. Expert Opin Biol Ther. 2017. PMID: 28682112 Review.
In this context, TNF blockers have been a major therapeutic advance. Etanercept is a soluble recombinant TNF receptor fusion protein in this vain. ...Etanercept was also shown to reduce MRI inflammation on the spine and the sacroiliac joints. ...
In this context, TNF blockers have been a major therapeutic advance. Etanercept is a soluble recombinant TNF receptor fusion p …
Immunomodulation in Primary Immune Thrombocytopenia: A Possible Role of the Fc Fragment of Romiplostim?
Schifferli A, Nimmerjahn F, Kühne T. Schifferli A, et al. Front Immunol. 2019 Jun 4;10:1196. doi: 10.3389/fimmu.2019.01196. eCollection 2019. Front Immunol. 2019. PMID: 31214173 Free PMC article. Review.
The primary aim of this drug construct is to prolong the half-life of the active component. This molecular architecture is seen in drugs, such as etanercept, romiplostim, and the recombinant factor VIII (efmoroctocog alfa). ...
The primary aim of this drug construct is to prolong the half-life of the active component. This molecular architecture is seen in drugs, su …
Juvenile rheumatoid arthritis: therapeutic perspectives.
Chikanza IC. Chikanza IC. Paediatr Drugs. 2002;4(5):335-48. doi: 10.2165/00128072-200204050-00006. Paediatr Drugs. 2002. PMID: 11994038 Review.
Some of these biodrugs, such as anti-tumor necrosis factor alpha (anti-TNFalpha), monoclonal antibodies (infliximab, adalimumab), TNF soluble receptor constructs (etanercept) and interleukin-1 receptor antagonist (IL-1Ra) have been tested and shown to be effective in RA. …
Some of these biodrugs, such as anti-tumor necrosis factor alpha (anti-TNFalpha), monoclonal antibodies (infliximab, adalimumab), TNF solubl …
Biologic therapy for inflammatory bowel disease.
Ardizzone S, Bianchi Porro G. Ardizzone S, et al. Drugs. 2005;65(16):2253-86. doi: 10.2165/00003495-200565160-00002. Drugs. 2005. PMID: 16266194 Review.
The role of intestinal milieu, and enteric flora in particular, appears to be of greater significance than previously thought. This complex interplay of genetic, microbial and environmental factors culminates in a sustained activation of the mucosal immune and non-immune r …
The role of intestinal milieu, and enteric flora in particular, appears to be of greater significance than previously thought. This complex …
Transient expression of etanercept therapeutic protein in tobacco (Nicotiana tabacum L.).
Bidarigh Fard A, Dehghan Nayeri F, Habibi Anbuhi M. Bidarigh Fard A, et al. Int J Biol Macromol. 2019 Jun 1;130:483-490. doi: 10.1016/j.ijbiomac.2019.02.153. Epub 2019 Feb 27. Int J Biol Macromol. 2019. PMID: 30825567
Etanercept is a recombinant fusion protein of TNFR2 with the Fc portion of human IgG1. ...To evaluate the transient expression of the gene, agroinfiltrated tobacco leaves were inoculated with Agrobacterium tumefaciens containing etanercept gene cassette. The …
Etanercept is a recombinant fusion protein of TNFR2 with the Fc portion of human IgG1. ...To evaluate the transient expression …
Chimeric fusion proteins used for therapy: indications, mechanisms, and safety.
Baldo BA. Baldo BA. Drug Saf. 2015 May;38(5):455-79. doi: 10.1007/s40264-015-0285-9. Drug Saf. 2015. PMID: 25832756 Review.
This review covers eight fusion proteins that have received regulatory approval for human therapy: etanercept, belatacept, abatacept, alefacept, rilonacept, romiplostim, aflibercept, and denileukin-diftitox. ...Clinical findings with the anti-arthritis anti-psoriasis biolo …
This review covers eight fusion proteins that have received regulatory approval for human therapy: etanercept, belatacept, abatacept, …
Etanercept-Synthesising Mesenchymal Stem Cells Efficiently Ameliorate Collagen-Induced Arthritis.
Park N, Rim YA, Jung H, Kim J, Yi H, Kim Y, Jang Y, Jung SM, Lee J, Kwok SK, Park SH, Ju JH. Park N, et al. Sci Rep. 2017 Jan 13;7:39593. doi: 10.1038/srep39593. Sci Rep. 2017. PMID: 28084468 Free PMC article.
Biologics are made of protein components, and thus can be theoretically produced from cells including MSCs. MSCs were transfected with recombinant minicircles encoding etanercept (trade name, Enbrel), which is a tumour necrosis factor alpha blocker currently used to …
Biologics are made of protein components, and thus can be theoretically produced from cells including MSCs. MSCs were transfected with re …
112 results