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Year Number of Results
1998 1
2000 1
2001 2
2004 1
2005 2
2006 2
2007 1
2008 5
2009 3
2010 1
2011 1
2012 2
2013 3
2014 1
2016 1
2022 3
2023 1
2024 1

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28 results

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Page 1
Fudosteine attenuates acute lung injury in septic mice by inhibiting pyroptosis via the TXNIP/NLRP3/GSDMD pathway.
He G, Chen K, Wang H, Li X, Li W, Liu L, Chen J, Yang D, Hu J, Xu D, Wen F, Wang T. He G, et al. Eur J Pharmacol. 2022 Jul 5;926:175047. doi: 10.1016/j.ejphar.2022.175047. Epub 2022 May 21. Eur J Pharmacol. 2022. PMID: 35609679
This study aimed to investigate the effects and mechanisms of fudosteine in a mouse model of sepsis-induced ALI. Sepsis was induced by cecal ligation and puncture (CLP). ...The lung injury score was significantly lowered by fudosteine [e.g., 0.18 0.03 (100 mg/kg) vs …
This study aimed to investigate the effects and mechanisms of fudosteine in a mouse model of sepsis-induced ALI. Sepsis was induced b …
Pharmacokinetics and Bioequivalence of Fudosteine in Healthy Chinese Volunteers Under Fasting and Fed Conditions: A 4-Way Replicate Crossover Study.
Zhu M, Tao Y, Pu J, Zhao H, Wan L, Zhang P, Tang C. Zhu M, et al. Clin Pharmacol Drug Dev. 2023 Jan;12(1):30-37. doi: 10.1002/cpdd.1137. Epub 2022 Jul 6. Clin Pharmacol Drug Dev. 2023. PMID: 35794358 Free PMC article. Clinical Trial.
The bioequivalence of a generic fudosteine tablet vs a brand-named fudosteine tablet under fasting and fed conditions was evaluated in this study. ...The plasma concentrations of fudosteine were analyzed by high-performance liquid chromatography-tandem mass s …
The bioequivalence of a generic fudosteine tablet vs a brand-named fudosteine tablet under fasting and fed conditions was eval …
Fudosteine effects on mucin production.
Antonela Antoniu S. Antonela Antoniu S. Expert Opin Investig Drugs. 2009 Jan;18(1):105-7. doi: 10.1517/13543780802623863. Expert Opin Investig Drugs. 2009. PMID: 19053887
OBJECTIVE: To analyse the results of a preclinical study assessing the pathogenic mechanisms of mucin hyperproduction and the consequent in vivo and in vitro effects of fudosteine, a mucoactive agent. METHODS/RESULTS: Both LPS and TNF-alpha increased MUC5AC mucin productio …
OBJECTIVE: To analyse the results of a preclinical study assessing the pathogenic mechanisms of mucin hyperproduction and the consequent in …
Effect of fudosteine on mucin production.
Rhee CK, Kang CM, You MB, Yoon HK, Kim YK, Kim KH, Moon HS, Park SH, Song JS. Rhee CK, et al. Eur Respir J. 2008 Nov;32(5):1195-202. doi: 10.1183/09031936.00018508. Epub 2008 Jun 25. Eur Respir J. 2008. PMID: 18579549 Free article.
Fudosteine is a novel mucoactive agent, although little is known about how fudosteine decreases mucin production. ...Fudosteine was administered before stimulation with LPS or TNF-alpha. ...
Fudosteine is a novel mucoactive agent, although little is known about how fudosteine decreases mucin production. ...Fudost …
Antioxidant pharmacological therapies for COPD.
Rahman I, MacNee W. Rahman I, et al. Curr Opin Pharmacol. 2012 Jun;12(3):256-65. doi: 10.1016/j.coph.2012.01.015. Epub 2012 Feb 18. Curr Opin Pharmacol. 2012. PMID: 22349417 Free PMC article. Review.
Thiol antioxidants (N-acetyl-l-cysteine [NAC] and N-acystelyn, carbocysteine, erdosteine, and fudosteine) have been used to increase lung thiol content. Modulation of cigarette smoke (CS) induced oxidative stress and its consequent cellular changes have also been reported …
Thiol antioxidants (N-acetyl-l-cysteine [NAC] and N-acystelyn, carbocysteine, erdosteine, and fudosteine) have been used to increase …
Effect of fudosteine, a cysteine derivative, on airway hyperresponsiveness, inflammation, and remodeling in a murine model of asthma.
Ueno-Iio T, Shibakura M, Iio K, Tanimoto Y, Kanehiro A, Tanimoto M, Kataoka M. Ueno-Iio T, et al. Life Sci. 2013 May 30;92(20-21):1015-23. doi: 10.1016/j.lfs.2013.03.022. Epub 2013 Apr 10. Life Sci. 2013. PMID: 23583570
AIMS: Fudosteine is a cysteine derivative that is used as an expectorant in chronic bronchial inflammatory disorders. ...The expression of TGF-beta, the development of goblet cell hyperplasia, subepithelial collagenization, and basement membrane thickening were also reduce …
AIMS: Fudosteine is a cysteine derivative that is used as an expectorant in chronic bronchial inflammatory disorders. ...The expressi …
Simultaneous Determination of Genotoxic Impurities in Fudosteine Drugs by GC-MS.
Gooty AR, Katreddi HR, S RR, Hunnur RK, Sharma HK, Masani NK. Gooty AR, et al. J Chromatogr Sci. 2016 Sep;54(8):1277-81. doi: 10.1093/chromsci/bmw070. Epub 2016 Jun 3. J Chromatogr Sci. 2016. PMID: 27261527
A simple, sensitive and reliable gas chromatography mass spectrometry (GC-MS) method has been developed, optimized and validated for the simultaneous determination of 3-chloro-1-propanol (CHP), 1,3-dichloropropane (DCP), 3-chloropropylacetate (CPA) and chloropropyl hydroxypropyl …
A simple, sensitive and reliable gas chromatography mass spectrometry (GC-MS) method has been developed, optimized and validated for the sim …
Pharmacological antioxidant strategies as therapeutic interventions for COPD.
Rahman I. Rahman I. Biochim Biophys Acta. 2012 May;1822(5):714-28. doi: 10.1016/j.bbadis.2011.11.004. Epub 2011 Nov 9. Biochim Biophys Acta. 2012. PMID: 22101076 Free PMC article. Review.
Various antioxidant agents, such as thiol molecules (glutathione and mucolytic drugs, such as N-acetyl-L-cysteine and N-acystelyn, erdosteine, fudosteine, ergothioneine, and carbocysteine), have been reported to modulate various cellular and biochemical aspects of COPD. .. …
Various antioxidant agents, such as thiol molecules (glutathione and mucolytic drugs, such as N-acetyl-L-cysteine and N-acystelyn, erdostein …
Antioxidant therapeutic advances in COPD.
Rahman I. Rahman I. Ther Adv Respir Dis. 2008 Dec;2(6):351-74. doi: 10.1177/1753465808098224. Ther Adv Respir Dis. 2008. PMID: 19124382 Free PMC article. Review.
Among the various antioxidants tried so far, thiol antioxidants and mucolytic agents, such as glutathione, N-acetyl-L-cysteine, N-acystelyn, erdosteine, fudosteine and carbocysteine; Nrf2 activators; and dietary polyphenols (curcumin, resveratrol, and green tea catechins/q …
Among the various antioxidants tried so far, thiol antioxidants and mucolytic agents, such as glutathione, N-acetyl-L-cysteine, N-acystelyn, …
Quantification of fudosteine in human plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry employing precolumn derivatization with 9-fluorenylmethyl chloroformate.
Xu F, Zhang Z, Jiao H, Tian Y, Zhang B, Chen Y. Xu F, et al. J Mass Spectrom. 2006 May;41(5):685-92. doi: 10.1002/jms.1028. J Mass Spectrom. 2006. PMID: 16598709 Clinical Trial.
After acetonitrile-induced protein precipitation of plasma samples, fudosteine was derivatized with FMOC-Cl, then extracted by ethyl acetate, evaporated, reconstituted and injected using an LC/ESI/MS instrument. ...The proposed method has been successfully applied to study …
After acetonitrile-induced protein precipitation of plasma samples, fudosteine was derivatized with FMOC-Cl, then extracted by ethyl …
28 results