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Allergic diseases: From bench to clinic - Contribution of the discovery of interleukin-5.
Yanagibashi T, Satoh M, Nagai Y, Koike M, Takatsu K. Yanagibashi T, et al. Cytokine. 2017 Oct;98:59-70. doi: 10.1016/j.cyto.2016.11.011. Cytokine. 2017. PMID: 28863833 Review.
Although IL-5 was initially identified by its ability to support the growth and terminal differentiation of mouse B cells into antibody-secreting cells, recombinant IL-5 exerts pleiotropic activities on various target cells. ...
Although IL-5 was initially identified by its ability to support the growth and terminal differentiation of mouse B cells into antibody-secr …
Eosinophil peroxidase activates cells by HER2 receptor engagement and β1-integrin clustering with downstream MAPK cell signaling.
Hennigan K, Conroy PJ, Walsh MT, Amin M, O'Kennedy R, Ramasamy P, Gleich GJ, Siddiqui Z, Glynn S, McCabe O, Mooney C, Harvey BJ, Costello RW, McBryan J. Hennigan K, et al. Clin Immunol. 2016 Oct;171:1-11. doi: 10.1016/j.clim.2016.08.009. Epub 2016 Aug 9. Clin Immunol. 2016. PMID: 27519953 Free PMC article.
Eosinophils account for 1-3% of peripheral blood leukocytes and accumulate at sites of allergic inflammation, where they play a pathogenic role. Studies have shown that treatment with mepolizumab (an anti-IL-5 monoclonal antibody) is beneficial to patients with severe eosi …
Eosinophils account for 1-3% of peripheral blood leukocytes and accumulate at sites of allergic inflammation, where they play a pathogenic r …