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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 3
1974 3
1975 9
1976 12
1977 43
1978 35
1979 28
1980 55
1981 44
1982 47
1983 58
1984 75
1985 74
1986 65
1987 65
1988 54
1989 63
1990 53
1991 70
1992 67
1993 53
1994 33
1995 42
1996 27
1997 36
1998 38
1999 38
2000 44
2001 37
2002 41
2003 39
2004 42
2005 43
2006 40
2007 43
2008 35
2009 35
2010 40
2011 30
2012 43
2013 41
2014 31
2015 39
2016 36
2017 42
2018 35
2019 42
2020 51
2021 52
2022 44
2023 46
2024 18

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2,077 results

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Page 1
About the different faces of mexiletine.
Postema PG. Postema PG. Heart Rhythm. 2020 Nov;17(11):1951-1952. doi: 10.1016/j.hrthm.2020.06.013. Epub 2020 Jun 13. Heart Rhythm. 2020. PMID: 32544436 No abstract available.
Mexiletine.
Danilo P Jr. Danilo P Jr. Am Heart J. 1979 Mar;97(3):399-403. doi: 10.1016/0002-8703(79)90442-3. Am Heart J. 1979. PMID: 420082 No abstract available.
Mexiletine metabolites: a review.
Catalano A, Carocci A, Sinicropi MS. Catalano A, et al. Curr Med Chem. 2015;22(11):1400-13. doi: 10.2174/0929867322666150227145412. Curr Med Chem. 2015. PMID: 25723511 Review.
Mexiletine belongs to class IB antiarrhythmic drugs and it is still considered a drug of choice for treating myotonias. ...Mexiletine is extensive metabolized in humans via phase I and phase II reactions. ...
Mexiletine belongs to class IB antiarrhythmic drugs and it is still considered a drug of choice for treating myotonias. ...Mexilet …
Mexiletine in spinal and bulbar muscular atrophy: a randomized controlled trial.
Yamada S, Hashizume A, Hijikata Y, Inagaki T, Ito D, Kishimoto Y, Kinoshita F, Hirakawa A, Shimizu S, Nakamura T, Katsuno M. Yamada S, et al. Ann Clin Transl Neurol. 2022 Nov;9(11):1702-1714. doi: 10.1002/acn3.51667. Epub 2022 Oct 8. Ann Clin Transl Neurol. 2022. PMID: 36208052 Free PMC article. Clinical Trial.
METHODS: In our previously conducted observational study, we assessed nerve conduction and grip strength to examine the effect of cold exposure on motor function, based on which we conducted a randomized controlled trial to evaluate the efficacy and safety of mexiletine …
METHODS: In our previously conducted observational study, we assessed nerve conduction and grip strength to examine the effect of cold expos …
Mexiletine: Antiarrhythmic mechanisms, emerging clinical applications and mortality.
Olleik F, Kamareddine MH, Spears J, Tse G, Liu T, Yan GX. Olleik F, et al. Pacing Clin Electrophysiol. 2023 Nov;46(11):1348-1356. doi: 10.1111/pace.14846. Epub 2023 Oct 17. Pacing Clin Electrophysiol. 2023. PMID: 37846818 Review.
Mexiletine, a class Ib antiarrhythmic drug, exhibits its major antiarrhythmic effect via inhibition of the fast and late Na(+) currents in myocardial tissues that are dependent on the opening of Na(+) channels for their excitation. ...This review will highlight the current …
Mexiletine, a class Ib antiarrhythmic drug, exhibits its major antiarrhythmic effect via inhibition of the fast and late Na(+) curren …
Mexiletine.
Campbell RW. Campbell RW. N Engl J Med. 1987 Jan 1;316(1):29-34. doi: 10.1056/NEJM198701013160106. N Engl J Med. 1987. PMID: 3537793 Review. No abstract available.
Mexiletine: pharmacology and therapeutic use.
Manolis AS, Deering TF, Cameron J, Estes NA 3rd. Manolis AS, et al. Clin Cardiol. 1990 May;13(5):349-59. doi: 10.1002/clc.4960130509. Clin Cardiol. 1990. PMID: 2189614 Free article. Review.
Mexiletine is a Class IB antiarrhythmic which has basic and clinical electrophysiologic properties similar to lidocaine. Like other Class I antiarrhythmic agents, mexiletine blocks the rapid inward sodium current responsible for phase 0 of the action potential. ...
Mexiletine is a Class IB antiarrhythmic which has basic and clinical electrophysiologic properties similar to lidocaine. Like other C …
Clinical pharmacokinetics of mexiletine.
Labbé L, Turgeon J. Labbé L, et al. Clin Pharmacokinet. 1999 Nov;37(5):361-84. doi: 10.2165/00003088-199937050-00002. Clin Pharmacokinet. 1999. PMID: 10589372 Review.
The major metabolites are hydroxymethyl-mexiletine, p-hydroxy-mexiletine, m-hydroxy-mexiletine and N-hydroxy-mexiletine. Formation of hydroxymethyl-mexiletine, p-hydroxy-mexiletine and m-hydroxy-mexiletine is genetically determined …
The major metabolites are hydroxymethyl-mexiletine, p-hydroxy-mexiletine, m-hydroxy-mexiletine and N-hydroxy-mexilet …
Mexiletine. A review of its therapeutic use in painful diabetic neuropathy.
Jarvis B, Coukell AJ. Jarvis B, et al. Drugs. 1998 Oct;56(4):691-707. doi: 10.2165/00003495-199856040-00016. Drugs. 1998. PMID: 9806111 Review.
EMs, but not PMs, are susceptible to drug interactions between mexiletine and drugs that inhibit CYP2D6 (e.g. quinidine). Moreover, mexiletine inhibits CYP2D6-mediated metabolism of metoprolol and cytochrome P450 1A2-mediated metabolism of theophylline. Phenytoin an …
EMs, but not PMs, are susceptible to drug interactions between mexiletine and drugs that inhibit CYP2D6 (e.g. quinidine). Moreover, …
Pharmacology, electrophysiology, and pharmacokinetics of mexiletine.
Woosley RL, Wang T, Stone W, Siddoway L, Thompson K, Duff HJ, Cerskus I, Roden D. Woosley RL, et al. Am Heart J. 1984 May;107(5 Pt 2):1058-65. doi: 10.1016/0002-8703(84)90175-3. Am Heart J. 1984. PMID: 6326558 Review.
Uptake and distribution of mexiletine are rapid, systemic bioavailability is about 90%, and tissue distribution is extensive. Mexiletine is primarily metabolized in the liver; 10% to 15% is excreted unchanged in the urine. ...
Uptake and distribution of mexiletine are rapid, systemic bioavailability is about 90%, and tissue distribution is extensive. Mexi …
2,077 results