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Year Number of Results
1982 3
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1984 7
1985 12
1986 4
1987 6
1988 3
1989 5
1990 3
1991 1
1992 4
1993 6
1994 4
1995 6
1996 10
1997 5
1998 4
1999 4
2000 2
2001 7
2002 17
2003 2
2004 11
2005 6
2006 9
2007 6
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2014 1
2017 1
2024 0

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Page 1
Effects of nipradilol on alpha-adrenoceptor function in ocular arteries.
Okamura T, Fujioka H, Ayajiki K. Okamura T, et al. Pharmacology. 2002 May;65(2):110-8. doi: 10.1159/000056195. Pharmacology. 2002. PMID: 11937782
However, nipradilol inhibited the phenylephrine-induced contraction with a similar PA(2) value of prazosin. ...The contraction induced by phenylephrine was significantly inhibited by prazosin and nipradilol. It is concluded that nipradilol acts as an alpha(1) …
However, nipradilol inhibited the phenylephrine-induced contraction with a similar PA(2) value of prazosin. ...The contraction induce …
Topical nipradilol: effects on optic nerve head circulation in humans and periocular distribution in monkeys.
Mizuno K, Koide T, Saito N, Fujii M, Nagahara M, Tomidokoro A, Tamaki Y, Araie M. Mizuno K, et al. Invest Ophthalmol Vis Sci. 2002 Oct;43(10):3243-50. Invest Ophthalmol Vis Sci. 2002. PMID: 12356831
PURPOSE: To investigate the effects of topical nipradilol on blood velocity in the optic nerve head (ONH) in normal humans and the ocular and periocular distribution of topically instilled nipradilol in monkeys. ...In monkeys, after a single instillation of 1% [(14) …
PURPOSE: To investigate the effects of topical nipradilol on blood velocity in the optic nerve head (ONH) in normal humans and the oc …
Nipradilol, a new beta-blocker with vasodilatory properties, in experimental portal hypertension: a comparative haemodynamic study with propranolol.
Um S, Nishida O, Tokubayashi M, Kimura F, Kita T. Um S, et al. J Gastroenterol Hepatol. 1993 Sep-Oct;8(5):414-9. doi: 10.1111/j.1440-1746.1993.tb01540.x. J Gastroenterol Hepatol. 1993. PMID: 8105997
Portal hypertensive rats were divided into five groups receiving infusion of placebo, 3 mg of propranolol, 300, 600 and 1200 micrograms of nipradilol. At its highest dose, nipradilol achieved a reduction of 34.4 +/- 4.4% in heart rate which was similar to that in th …
Portal hypertensive rats were divided into five groups receiving infusion of placebo, 3 mg of propranolol, 300, 600 and 1200 micrograms of …
Nipradilol inhibits apoptosis by preventing the activation of caspase-3 via S-nitrosylation and the cGMP-dependent pathway.
Tomita H, Nakazawa T, Sugano E, Abe T, Tamai M. Tomita H, et al. Eur J Pharmacol. 2002 Oct 11;452(3):263-8. doi: 10.1016/s0014-2999(02)02329-4. Eur J Pharmacol. 2002. PMID: 12359266
Nipradilol has alpha1- and beta-adrenoceptor-blocking and nitric oxide (NO)-donating properties. ...KT5823 partially reversed the nipradilol-mediated cytoprotective effect. These results indicate that the cytoprotective effect of nipradilol in PC12 cell death …
Nipradilol has alpha1- and beta-adrenoceptor-blocking and nitric oxide (NO)-donating properties. ...KT5823 partially reversed the …
Nipradilol inhibits atmospheric pressure-induced cell proliferation in human aortic smooth muscle cells.
Iizuka K, Morita N, Murakami T, Kawaguchi H. Iizuka K, et al. Pharmacol Res. 2004 Mar;49(3):217-25. doi: 10.1016/j.phrs.2003.09.011. Pharmacol Res. 2004. PMID: 14726216
An administration of L-NAME (10(-4)M) supplemented with Nipradilol (10(-6)M) did not show any significant effect on cell proliferation. From these observations, we concluded that nipradilol has an anti-proliferative effect on HASMC under high atmospheric pressure. . …
An administration of L-NAME (10(-4)M) supplemented with Nipradilol (10(-6)M) did not show any significant effect on cell proliferatio …
Nipradilol promotes axon regeneration through S-nitrosylation of PTEN in retinal ganglion cells.
Koriyama Y, Kamiya M, Arai K, Sugitani K, Ogai K, Kato S. Koriyama Y, et al. Adv Exp Med Biol. 2014;801:751-7. doi: 10.1007/978-1-4614-3209-8_94. Adv Exp Med Biol. 2014. PMID: 24664767
Nipradilol (Nip) is registered as an anti-glaucoma agent. More recently, a protective effect of Nip has been demonstrated in retinal ganglion cells (RGCs) mediated by S-nitrosylation of antioxidative-related Keap1 protein due to its nitric oxide (NO)-donating effect. ...
Nipradilol (Nip) is registered as an anti-glaucoma agent. More recently, a protective effect of Nip has been demonstrated in retinal …
Vasodilatory effects of nipradilol, an alpha- and beta-adrenergic blocker with nitric oxide releasing action, in rabbit ciliary artery.
Yoshitomi T, Yamaji K, Ishikawa H, Ohnishi Y. Yoshitomi T, et al. Exp Eye Res. 2002 Dec;75(6):669-76. doi: 10.1006/exer.2002.2061. Exp Eye Res. 2002. PMID: 12470968
Nipradilol is a new antiglaucoma ophthalmic agent used in Japan. Topical application of nipradilol is reported to increase ocular blood flow. ...First, the relaxation is due to the NO produced by denitrification of nipradilol itself. Second, nipradilol …
Nipradilol is a new antiglaucoma ophthalmic agent used in Japan. Topical application of nipradilol is reported to increase ocu …
Direct nitric oxide release from nipradilol in human coronary arterial smooth muscle cells observed with fluorescent NO probe and NO-electrode.
Ishida H, Hirota Y, Higashijima N, Ishiwata K, Chokoh G, Matsuyama S, Murakami E, Nakazawa H. Ishida H, et al. Pathophysiology. 2004 Oct;11(2):77-80. doi: 10.1016/j.pathophys.2004.03.004. Pathophysiology. 2004. PMID: 15364117 Free article.
The cells showed no fluorescence at baseline, but intense fluorescence appeared at 30min after addition of 10microM nipradilol. The intensities of fluorescence at 30min in the control, nipradilol and nipradilol with ethacrynic acid groups were 98 +/- 6, 163 + …
The cells showed no fluorescence at baseline, but intense fluorescence appeared at 30min after addition of 10microM nipradilol. The i …
Actions of nipradilol (K-351), a new alpha- and beta-adrenoceptor blocker, on the rabbit portal vein.
Nanjo T, Kitamura K. Nanjo T, et al. Jpn J Pharmacol. 1984 Aug;35(4):359-69. doi: 10.1254/jjp.35.359. Jpn J Pharmacol. 1984. PMID: 6150128 Free article.
Nipradilol but not desnitro nipradilol [N-) nipradilol) inhibited the norepinephrine (NE)-induced depolarization and contraction of the rabbit portal vein. ...The potency of beta-blocking actions of nipradilol was much the same as that observed by prop …
Nipradilol but not desnitro nipradilol [N-) nipradilol) inhibited the norepinephrine (NE)-induced depolarization and co …
Nipradilol protects rat retinal ganglion cells from apoptosis induced by serum deprivation in vitro and by diabetes in vivo.
Tatsumi Y, Kanamori A, Nagai-Kusuhara A, Nakanishi Y, Agarwal N, Negi A, Nakamura M. Tatsumi Y, et al. Curr Eye Res. 2008 Aug;33(8):683-92. doi: 10.1080/02713680802323157. Curr Eye Res. 2008. PMID: 18696344
Removal of the nitric oxide moiety from nipradilol blocked these effects. CONCLUSIONS: Nipradilol protects RGCs from apoptosis induced by serum-deprivation in vitro and by diabetes in vivo. The NO-related signaling pathway mediates the anti-apoptotic ability of n …
Removal of the nitric oxide moiety from nipradilol blocked these effects. CONCLUSIONS: Nipradilol protects RGCs from apoptosis …
167 results