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Consensus classification of posterior cortical atrophy.
Crutch SJ, Schott JM, Rabinovici GD, Murray M, Snowden JS, van der Flier WM, Dickerson BC, Vandenberghe R, Ahmed S, Bak TH, Boeve BF, Butler C, Cappa SF, Ceccaldi M, de Souza LC, Dubois B, Felician O, Galasko D, Graff-Radford J, Graff-Radford NR, Hof PR, Krolak-Salmon P, Lehmann M, Magnin E, Mendez MF, Nestor PJ, Onyike CU, Pelak VS, Pijnenburg Y, Primativo S, Rossor MN, Ryan NS, Scheltens P, Shakespeare TJ, Suárez González A, Tang-Wai DF, Yong KXX, Carrillo M, Fox NC; Alzheimer's Association ISTAART Atypical Alzheimer's Disease and Associated Syndromes Professional Interest Area. Crutch SJ, et al. Alzheimers Dement. 2017 Aug;13(8):870-884. doi: 10.1016/j.jalz.2017.01.014. Epub 2017 Mar 2. Alzheimers Dement. 2017. PMID: 28259709 Free PMC article.
INTRODUCTION: A classification framework for posterior cortical atrophy (PCA) is proposed to improve the uniformity of definition of the syndrome in a variety of research settings. ...
INTRODUCTION: A classification framework for posterior cortical atrophy (PCA) is proposed to improve the uniformity of …
Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study.
Thijssen EH, La Joie R, Strom A, Fonseca C, Iaccarino L, Wolf A, Spina S, Allen IE, Cobigo Y, Heuer H, VandeVrede L, Proctor NK, Lago AL, Baker S, Sivasankaran R, Kieloch A, Kinhikar A, Yu L, Valentin MA, Jeromin A, Zetterberg H, Hansson O, Mattsson-Carlgren N, Graham D, Blennow K, Kramer JH, Grinberg LT, Seeley WW, Rosen H, Boeve BF, Miller BL, Teunissen CE, Rabinovici GD, Rojas JC, Dage JL, Boxer AL; Advancing Research and Treatment for Frontotemporal Lobar Degeneration investigators. Thijssen EH, et al. Lancet Neurol. 2021 Sep;20(9):739-752. doi: 10.1016/S1474-4422(21)00214-3. Lancet Neurol. 2021. PMID: 34418401 Free PMC article.
METHODS: In this retrospective multicohort diagnostic performance study, we analysed plasma samples, obtained from patients aged 18-99 years old who had been diagnosed with Alzheimer's disease syndromes (Alzheimer's disease dementia, logopenic variant primary progressive aphasia, …
METHODS: In this retrospective multicohort diagnostic performance study, we analysed plasma samples, obtained from patients aged 18-99 years …
Posterior cortical atrophy: Primary occipital variant.
Shir D, Graff-Radford J, Machulda MM, Pham NTT, Jack CR Jr, Lowe VJ, Whitwell JL, Josephs KA. Shir D, et al. Eur J Neurol. 2022 Jul;29(7):2138-2143. doi: 10.1111/ene.15327. Epub 2022 Mar 30. Eur J Neurol. 2022. PMID: 35298068 Free PMC article.
BACKGROUND: Posterior cortical atrophy (PCA) is one of the atypical Alzheimer's disease variants, characterized by predominant visuospatial and visuoperceptual deficits, with established dorsal and ventral subtypes. ...
BACKGROUND: Posterior cortical atrophy (PCA) is one of the atypical Alzheimer's disease variants, characterized by pred …
Diagnosis and Management of Posterior Cortical Atrophy.
Yong KXX, Graff-Radford J, Ahmed S, Chapleau M, Ossenkoppele R, Putcha D, Rabinovici GD, Suarez-Gonzalez A, Schott JM, Crutch S, Harding E. Yong KXX, et al. Curr Treat Options Neurol. 2023;25(2):23-43. doi: 10.1007/s11940-022-00745-0. Epub 2023 Feb 8. Curr Treat Options Neurol. 2023. PMID: 36820004 Free PMC article. Review.
PURPOSE OF REVIEW: The study aims to provide a summary of recent developments for diagnosing and managing posterior cortical atrophy (PCA). We present current efforts to improve PCA characterisation and recommendations regarding use of clinical, neuropsycholo …
PURPOSE OF REVIEW: The study aims to provide a summary of recent developments for diagnosing and managing posterior cortical …
Phonological Errors in Posterior Cortical Atrophy.
Tetzloff KA, Duffy JR, Strand EA, Machulda MM, Schwarz CG, Senjem ML, Jack CR, Josephs KA, Whitwell JL. Tetzloff KA, et al. Dement Geriatr Cogn Disord. 2021;50(2):195-203. doi: 10.1159/000516481. Epub 2021 Jul 16. Dement Geriatr Cogn Disord. 2021. PMID: 34274933 Free PMC article.
BACKGROUND: Posterior cortical atrophy (PCA) is an atypical variant of Alzheimer's disease (AD) that presents with visuospatial/perceptual deficits. ...
BACKGROUND: Posterior cortical atrophy (PCA) is an atypical variant of Alzheimer's disease (AD) that presents with visu …
Regional white matter hyperintensities in posterior cortical atrophy and logopenic progressive aphasia.
Pham NTT, Graff-Radford J, Machulda MM, Spychalla AJ, Schwarz CG, Senjem ML, Lowe VJ, Vemuri P, Kantarci K, Knopman DS, Petersen RC, Jack CR, Josephs KA, Whitwell JL. Pham NTT, et al. Neurobiol Aging. 2022 Nov;119:46-55. doi: 10.1016/j.neurobiolaging.2022.07.008. Epub 2022 Jul 28. Neurobiol Aging. 2022. PMID: 35970009 Free PMC article.
Little is known about the frequency and distribution of WMH in atypical variants of AD, including logopenic progressive aphasia (LPA) and posterior cortical atrophy (PCA). We investigated WMHs in 75 LPA, 39 PCA, and 50 tAD patients and associations with age, …
Little is known about the frequency and distribution of WMH in atypical variants of AD, including logopenic progressive aphasia (LPA) and …
Posterior cortical atrophy phenotypic heterogeneity revealed by decoding (18)F-FDG-PET.
Townley RA, Botha H, Graff-Radford J, Whitwell J, Boeve BF, Machulda MM, Fields JA, Drubach DA, Savica R, Petersen RC, Senjem ML, Knopman DS, Lowe VJ, Jack CR Jr, Josephs KA, Jones DT. Townley RA, et al. Brain Commun. 2021 Aug 19;3(4):fcab182. doi: 10.1093/braincomms/fcab182. eCollection 2021. Brain Commun. 2021. PMID: 34805993 Free PMC article.
Posterior cortical atrophy is a neurodegenerative syndrome with a heterogeneous clinical presentation due to variable involvement of the left, right, dorsal and ventral parts of the visual system, as well as inconsistent involvement of other cognitive domains …
Posterior cortical atrophy is a neurodegenerative syndrome with a heterogeneous clinical presentation due to variable i …
Medial Temporal Atrophy in Posterior Cortical Atrophy and Its Relationship to the Cingulate Island Sign.
Josephs KA, Pham NTT, Graff-Radford J, Machulda MM, Lowe VJ, Whitwell JL. Josephs KA, et al. J Alzheimers Dis. 2022;86(1):491-498. doi: 10.3233/JAD-215263. J Alzheimers Dis. 2022. PMID: 35068459 Free PMC article.
BACKGROUND: It has been hypothesized that medial temporal sparing may be related to preserved posterior cingulate metabolism and the cingulate island sign (CIS) on [18F]fluorodeoxyglucose (FDG) PET in posterior cortical atrophy (PCA). OBJECTIVE: To assess the …
BACKGROUND: It has been hypothesized that medial temporal sparing may be related to preserved posterior cingulate metabolism and the cingula …
Temporal Cortical Thickness and Cognitive Associations among Typical and Atypical Phenotypes of Alzheimer's Disease.
Butts AM, Machulda MM, Martin P, Przybelski SA, Duffy JR, Graff-Radford J, Knopman DS, Petersen RC, Jack CR Jr, Lowe VJ, Josephs KA, Whitwell JL. Butts AM, et al. J Alzheimers Dis Rep. 2022 Aug 5;6(1):479-491. doi: 10.3233/ADR-220010. eCollection 2022. J Alzheimers Dis Rep. 2022. PMID: 36186727 Free PMC article.
OBJECTIVE: Our goal was to compare temporal lobe regions between tAD and two atypical AD phenotypes (logopenic progressive aphasia (LPA) and posterior cortical atrophy (PCA)), and assess cognitive associations. ...
OBJECTIVE: Our goal was to compare temporal lobe regions between tAD and two atypical AD phenotypes (logopenic progressive aphasia (LPA) and …
(18)F-FDG PET in Posterior Cortical Atrophy and Dementia with Lewy Bodies.
Whitwell JL, Graff-Radford J, Singh TD, Drubach DA, Senjem ML, Spychalla AJ, Tosakulwong N, Lowe VJ, Josephs KA. Whitwell JL, et al. J Nucl Med. 2017 Apr;58(4):632-638. doi: 10.2967/jnumed.116.179903. Epub 2016 Sep 29. J Nucl Med. 2017. PMID: 27688479 Free PMC article.
Posterior cortical atrophy (PCA) and dementia with Lewy bodies (DLB) have both been associated with occipital lobe hypometabolism on (18)F-FDG PET, whereas relative sparing of posterior cingulate metabolism compared with precuneus/cuneus (i.e., cingulate isla …
Posterior cortical atrophy (PCA) and dementia with Lewy bodies (DLB) have both been associated with occipital lobe hypo …
52 results