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160 results

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Page 1
Suplatast tosilate reduces radiation-induced lung injury in mice through suppression of oxidative stress.
Izumi Y, Nakashima T, Masuda T, Shioya S, Fukuhara K, Yamaguchi K, Sakamoto S, Horimasu Y, Miyamoto S, Iwamoto H, Fujitaka K, Hamada H, Hattori N. Izumi Y, et al. Free Radic Biol Med. 2019 May 20;136:52-59. doi: 10.1016/j.freeradbiomed.2019.03.024. Epub 2019 Mar 28. Free Radic Biol Med. 2019. PMID: 30930296
Because ROS-mediated oxidative stress is involved in radiation-induced lung injury, we hypothesized that suplatast tosilate could reduce radiation-induced lung injury via suppression of oxidative stress. ...CONCLUSIONS: These findings demonstrate that suplatast …
Because ROS-mediated oxidative stress is involved in radiation-induced lung injury, we hypothesized that suplatast tosilate co …
Suplatast tosilate protects the lung against hyperoxic lung injury by scavenging hydroxyl radicals.
Fukuhara K, Nakashima T, Abe M, Masuda T, Hamada H, Iwamoto H, Fujitaka K, Kohno N, Hattori N. Fukuhara K, et al. Free Radic Biol Med. 2017 May;106:1-9. doi: 10.1016/j.freeradbiomed.2017.02.014. Epub 2017 Feb 7. Free Radic Biol Med. 2017. PMID: 28188922
This finding suggests that suplatast tosilate exerts an antioxidant activity in vivo. In addition, we investigated whether suplatast tosilate has a scavenging effect on hydroxyl radical, the most reactive and harmful ROS, using electron paramagnetic re …
This finding suggests that suplatast tosilate exerts an antioxidant activity in vivo. In addition, we investigated whether …
Suplatast tosilate prevents bleomycin-induced pulmonary fibrosis in mice.
Furonaka M, Hattori N, Tanimoto T, Senoo T, Ishikawa N, Fujitaka K, Haruta Y, Yokoyama A, Kohno N. Furonaka M, et al. J Pharmacol Exp Ther. 2009 Jan;328(1):55-61. doi: 10.1124/jpet.108.141721. Epub 2008 Oct 2. J Pharmacol Exp Ther. 2009. PMID: 18832650
Therefore, we hypothesized that suplatast tosilate might have an inhibitory effect on the development of pulmonary fibrosis. ...We found that the treatment of mice with suplatast tosilate significantly reduced the degree of pulmonary fibrosis. ...
Therefore, we hypothesized that suplatast tosilate might have an inhibitory effect on the development of pulmonary fibrosis. . …
Suplatast tosilate in patients with interstitial cystitis: Efficacy and treatment possibilities, with suggestions for future assessments.
Ueda T, Homma Y, Yoshimura N. Ueda T, et al. Int J Urol. 2019 Jun;26 Suppl 1:4-11. doi: 10.1111/iju.13968. Int J Urol. 2019. PMID: 31144762 Clinical Trial.
OBJECTIVE: Suplatast tosilate, a Th2 cytokine inhibitor, was predicted to relieve interstitial cystitis symptoms. Four studies with suplatast tosilate in Japanese interstitial cystitis patients have been conducted: a single-arm clinical study, a phase …
OBJECTIVE: Suplatast tosilate, a Th2 cytokine inhibitor, was predicted to relieve interstitial cystitis symptoms. Four studies …
Progress in suplatast tosilate research.
Sano Y, Yamada H. Sano Y, et al. Clin Exp Allergy. 2007 Jul;37(7):970-2. doi: 10.1111/j.1365-2222.2007.02755.x. Clin Exp Allergy. 2007. PMID: 17581190 No abstract available.
Inhibition of suplatast tosilate on EPSC in the single paratracheal ganglion neurons attached with presynaptic boutons.
Zhou JR, Shirasaki T, Soeda F, Takahama K. Zhou JR, et al. J Neurophysiol. 2023 Jul 1;130(1):56-60. doi: 10.1152/jn.00151.2023. Epub 2023 Jun 7. J Neurophysiol. 2023. PMID: 37283483
Using single neurons of rat paratracheal ganglia (PTG) attached with presynaptic boutons, the effects of suplatast tosilate on excitatory postsynaptic currents (EPSCs) were investigated with nystatin-perforated patch-clamp recording technique. ...Thus suplatast inhi …
Using single neurons of rat paratracheal ganglia (PTG) attached with presynaptic boutons, the effects of suplatast tosilate on …
Suplatast tosilate inhibits goblet-cell metaplasia of airway epithelium in sensitized mice.
Shim JJ, Dabbagh K, Takeyama K, Burgel PR, Dao-Pick TP, Ueki IF, Nadel JA. Shim JJ, et al. J Allergy Clin Immunol. 2000 Apr;105(4):739-45. doi: 10.1067/mai.2000.105221. J Allergy Clin Immunol. 2000. PMID: 10756224
METHODS: In vitro, NCI-H292 cells were preincubated with suplatast tosilate (0.1-100 microgram/mL) 1 hour before adding human recombinant IL-4 (10 ng/mL). ...To evaluate effects of suplatast tosilate on goblet-cell metaplasia in OVA-sensitized mice, an …
METHODS: In vitro, NCI-H292 cells were preincubated with suplatast tosilate (0.1-100 microgram/mL) 1 hour before adding human …
Suplatast tosilate alleviates nasal symptoms through the suppression of nuclear factor of activated T-cells-mediated IL-9 gene expression in toluene-2,4-diisocyanate-sensitized rats.
Mizuguchi H, Orimoto N, Kadota T, Kominami T, Das AK, Sawada A, Tamada M, Miyagi K, Adachi T, Matsumoto M, Kosaka T, Kitamura Y, Takeda N, Fukui H. Mizuguchi H, et al. J Pharmacol Sci. 2016 Mar;130(3):151-8. doi: 10.1016/j.jphs.2015.12.008. Epub 2016 Jan 6. J Pharmacol Sci. 2016. PMID: 26874672 Free article.
However, long-term treatment with antihistamines does not completely resolve toluene-2,4-diisocyanate (TDI)-induced nasal symptoms, although it can decrease H1R gene expression to the basal level, suggesting additional signaling is responsible for the pathogenesis of the allergic …
However, long-term treatment with antihistamines does not completely resolve toluene-2,4-diisocyanate (TDI)-induced nasal symptoms, although …
The effects of suplatast tosilate treatment and prophylaxis on lung histopathology in a mouse model of chronic asthma.
Tuncel T, Karaman M, Ayyildiz ZA, Uysal P, Kiray M, Bagriyanik AH, Yilmaz O, Karaman O, Uzuner N. Tuncel T, et al. J Investig Med. 2014 Jan;62(1):56-61. doi: 10.2310/JIM.0000000000000012. J Investig Med. 2014. PMID: 24113733
INTRODUCTION: Suplatast tosilate is a medication that inhibits TH2-type cytokines. ...MATERIALS AND METHODS: Forty-two BALB/c mice were divided into 6 groups: group I (control), group II (vehicle control), group III (dexamethasone), group IV (prophylaxis with sup …
INTRODUCTION: Suplatast tosilate is a medication that inhibits TH2-type cytokines. ...MATERIALS AND METHODS: Forty-two BALB/c …
Suplatast tosilate alters DC1/DC2 balance in peripheral blood in bronchial asthma.
Yokomura K, Suda T, Matsuda H, Hashizume H, Asada K, Suzuki K, Chida K. Yokomura K, et al. J Asthma. 2005 Sep;42(7):567-70. doi: 10.1080/02770900500215913. J Asthma. 2005. PMID: 16169790
Suplatast tosilate is an antiallergic drug that selectively suppresses Th2-cytokine production and inhibits airway hyperresponsiveness and eosinophilic airway inflammation. ...In the present study, we attempted to clarify the effect of suplatast tosilate …
Suplatast tosilate is an antiallergic drug that selectively suppresses Th2-cytokine production and inhibits airway hyperrespon …
160 results