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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 2
1974 2
1975 5
1976 10
1977 3
1978 2
1980 11
1981 11
1982 8
1983 19
1984 13
1985 7
1986 11
1987 15
1988 14
1989 3
1990 17
1991 14
1992 8
1993 7
1994 12
1995 9
1996 11
1997 6
1998 11
1999 12
2000 5
2001 7
2002 5
2003 10
2004 3
2005 9
2006 5
2007 9
2008 6
2009 4
2010 6
2011 2
2012 2
2013 4
2014 1
2016 1
2017 1
2018 6
2020 3
2021 1
2022 2
2024 1

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329 results

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Page 1
Trapidil determines the fate of RHF rats through inhibition of ER stress.
Wang Y, Wang Y, Wei C, Wan Q, Fan Z, Xuan L, Geng W, Shao L, Long J, Gu J, Zhao M. Wang Y, et al. Arch Pharm Res. 2020 Apr;43(4):409-420. doi: 10.1007/s12272-020-01222-5. Epub 2020 Mar 14. Arch Pharm Res. 2020. PMID: 32172437
However, it is difficult to treat. It has been reported that trapidil (Tra) can improve the redox balance and cardiac conditions. ...
However, it is difficult to treat. It has been reported that trapidil (Tra) can improve the redox balance and cardiac conditions. ...
Trapidil induces osteogenesis by upregulating the signaling of bone morphogenetic proteins.
Kim B, Lee JH, Jin WJ, Kim HH, Ha H, Lee ZH. Kim B, et al. Cell Signal. 2018 Sep;49:68-78. doi: 10.1016/j.cellsig.2018.06.001. Epub 2018 Jun 5. Cell Signal. 2018. PMID: 29879471
A rat calvarial defect model was analyzed by micro-computed tomography and histology to determine the pro-osteogenic effect of trapidil in vivo. In addition, primary mouse calvarial osteoblast precursors were cultured in osteogenic differentiation medium with trapidil …
A rat calvarial defect model was analyzed by micro-computed tomography and histology to determine the pro-osteogenic effect of trapidil …
[Trapidil after one year].
Agus GB. Agus GB. Minerva Cardioangiol. 1993 May;41(5):159-66. Minerva Cardioangiol. 1993. PMID: 8373465 Review. Italian.
Trapidil has shown a more complete antithrombocytic activity than other antiaggregating drugs; as a matter of fact it inhibits the formation of TXA2 through a mechanism of receptorial antagonism and at the same time it favours an increase of prostacyclina from the arterial …
Trapidil has shown a more complete antithrombocytic activity than other antiaggregating drugs; as a matter of fact it inhibits the fo …
Trapidil, a platelet-derived growth factor antagonist, inhibits osteoclastogenesis by down-regulating NFATc1 and suppresses bone loss in mice.
Kim SD, Kim HN, Lee JH, Jin WJ, Hwang SJ, Kim HH, Ha H, Lee ZH. Kim SD, et al. Biochem Pharmacol. 2013 Sep 15;86(6):782-90. doi: 10.1016/j.bcp.2013.07.015. Epub 2013 Aug 6. Biochem Pharmacol. 2013. PMID: 23928189
In this study, we investigated the effects of trapidil on osteoclastogenesis and elucidated the possible mechanism of action of trapidil. ...Ectopic expression of a constitutively active form of NFATc1 reversed the anti-osteoclastogenic effect of trapidil, in …
In this study, we investigated the effects of trapidil on osteoclastogenesis and elucidated the possible mechanism of action of tr …
Trapidil-mediated inhibition of CNS remyelination results from reduced numbers and impaired differentiation of oligodendrocytes.
McKay JS, Blakemore WF, Franklin RJ. McKay JS, et al. Neuropathol Appl Neurobiol. 1998 Dec;24(6):498-506. doi: 10.1046/j.1365-2990.1998.00148.x. Neuropathol Appl Neurobiol. 1998. PMID: 9888160
The animals received daily intraperitoneal injections of trapidil (80 mg/kg) or saline for 21 days, beginning on the day of lesion induction. ...In addition, the numbers of myelin lamellae around remyelinated axons were fewer in trapidil-treated animals. These resul …
The animals received daily intraperitoneal injections of trapidil (80 mg/kg) or saline for 21 days, beginning on the day of lesion in …
Trapidil improves hemodynamic, echocardiographic and redox state parameters of right ventricle in monocrotaline-induced pulmonary arterial hypertension model.
Türck P, Lacerda DS, Carraro CC, de Lima-Seolin BG, Teixeira RB, Poletto Bonetto JH, Colombo R, Schenkel PC, Belló-Klein A, da Rosa Araujo AS. Türck P, et al. Biomed Pharmacother. 2018 Jul;103:182-190. doi: 10.1016/j.biopha.2018.04.001. Epub 2018 Apr 24. Biomed Pharmacother. 2018. PMID: 29653363
HYPOTHESIS: Trapidil can improve the redox balance and contribute to functional improvements of the RV in PAH. METHODS AND RESULTS: Male, 5week-old Wistar rats were divided into four groups: Control, Control + Trapidil, Monocrotaline and Monocrotaline + Trapidil …
HYPOTHESIS: Trapidil can improve the redox balance and contribute to functional improvements of the RV in PAH. METHODS AND RESULTS: M …
Intrepide; Trapidil eluting stent.
Khan M, Mhulláin FN, Nolan M. Khan M, et al. EuroIntervention. 2008 Nov;4(3):405-11. EuroIntervention. 2008. PMID: 19110816 Review. No abstract available.
Trapidil protects ischemic hearts from reperfusion injury by stimulating PKAII activity.
Sichelschmidt OJ, Hahnefeld C, Hohlfeld T, Herberg FW, Schrör K. Sichelschmidt OJ, et al. Cardiovasc Res. 2003 Jun 1;58(3):602-10. doi: 10.1016/s0008-6363(03)00261-x. Cardiovasc Res. 2003. PMID: 12798433
OBJECTIVE: The cardioprotective effects of trapidil on ischemic reperfused (I/R) rabbit hearts were studied. Recently, we had shown that trapidil might activate protein kinase A (PKA). ...This action might be involved in the cardioprotective effects of trapidil …
OBJECTIVE: The cardioprotective effects of trapidil on ischemic reperfused (I/R) rabbit hearts were studied. Recently, we had shown t …
Trapidil inhibits monocyte chemoattractant protein-1 and macrophage accumulation after balloon arterial injury in rabbits.
Poon M, Cohen J, Siddiqui Z, Fallon JT, Taubman MB. Poon M, et al. Lab Invest. 1999 Nov;79(11):1369-75. Lab Invest. 1999. PMID: 10576207
Trapidil (triazolopyrimidine) is an antiplatelet agent that acts in part as a phosphodiesterase inhibitor and as a competitive inhibitor of the platelet-derived growth factor (PDGF) receptor. ...Trapidil resulted in a 75% reduction in MCP-1 expression and macrophage …
Trapidil (triazolopyrimidine) is an antiplatelet agent that acts in part as a phosphodiesterase inhibitor and as a competitive inhibi …
Effect of trapidil in myocardial ischemia-reperfusion injury in rabbit.
Liu M, Sun Q, Wang Q, Wang X, Lin P, Yang M, Yan Y. Liu M, et al. Indian J Pharmacol. 2014 Mar-Apr;46(2):207-10. doi: 10.4103/0253-7613.129320. Indian J Pharmacol. 2014. PMID: 24741195 Free PMC article.
OBJECTIVES: To evaluate the cardioprotective effects of trapidil on myocardial ischemia-reperfusion injury (MIRI) in rabbits. ...CONCLUSION: Trapidil may attenuate the myocardial damage produced by IR injury and offer potential cardioprotective action....
OBJECTIVES: To evaluate the cardioprotective effects of trapidil on myocardial ischemia-reperfusion injury (MIRI) in rabbits. ...CONC …
329 results