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331 results

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Page 1
Dexmedetomidine Attenuates Neuroinflammation In LPS-Stimulated BV2 Microglia Cells Through Upregulation Of miR-340.
Bao Y, Zhu Y, He G, Ni H, Liu C, Ma L, Zhang L, Shi D. Bao Y, et al. Drug Des Devel Ther. 2019 Oct 3;13:3465-3475. doi: 10.2147/DDDT.S210511. eCollection 2019. Drug Des Devel Ther. 2019. PMID: 31631971 Free PMC article.
BACKGROUND: Dexmedetomidine (Dex) was reported to exhibit anti-inflammatory effect in the nervous system. ...Therefore, Dex might serve as a potential agent for the treatment of neuroinflammation....
BACKGROUND: Dexmedetomidine (Dex) was reported to exhibit anti-inflammatory effect in the nervous system. ...Therefore, Dex mi …
ROS-responsive polymer nanoparticles with enhanced loading of dexamethasone effectively modulate the lung injury microenvironment.
Muhammad W, Zhu J, Zhai Z, Xie J, Zhou J, Feng X, Feng B, Pan Q, Li S, Venkatesan R, Li P, Cao H, Gao C. Muhammad W, et al. Acta Biomater. 2022 Aug;148:258-270. doi: 10.1016/j.actbio.2022.06.024. Epub 2022 Jun 18. Acta Biomater. 2022. PMID: 35724918 Free PMC article.
DEX was released faster from the PFTU@DEX NPs in a ROS environment, which could scavenge excessive ROS efficiently both in vitro and in vivo. The PFTU NPs and PFTU@DEX NPs showed no hemolysis and cytotoxicity. Free DEX, PFTU NPs and PFTU@DEX NPs …
DEX was released faster from the PFTU@DEX NPs in a ROS environment, which could scavenge excessive ROS efficiently both in vit …
Reducing complement activation during sleep deprivation yields cognitive improvement by dexmedetomidine.
Zhai Q, Zhang Y, Ye M, Zhu S, Sun J, Wang Y, Deng B, Ma D, Wang Q. Zhai Q, et al. Br J Anaesth. 2023 Sep;131(3):542-555. doi: 10.1016/j.bja.2023.04.044. Epub 2023 Jul 29. Br J Anaesth. 2023. PMID: 37517957 Free article.
The neuromolecular and cellular changes that occurred in the presence and absence of DEX (100 mug kg(-1), i.v., at 1 pm and 3 pm every day) were also investigated. ...DEX restored synaptic connections and reversed cognitive deficits induced by CSR. ...
The neuromolecular and cellular changes that occurred in the presence and absence of DEX (100 mug kg(-1), i.v., at 1 pm and 3 pm ever …
Melatonin Inhibits the Ferroptosis Pathway in Rat Bone Marrow Mesenchymal Stem Cells by Activating the PI3K/AKT/mTOR Signaling Axis to Attenuate Steroid-Induced Osteoporosis.
Li M, Yang N, Hao L, Zhou W, Li L, Liu L, Yang F, Xu L, Yao G, Zhu C, Xu W, Fang S. Li M, et al. Oxid Med Cell Longev. 2022 Aug 18;2022:8223737. doi: 10.1155/2022/8223737. eCollection 2022. Oxid Med Cell Longev. 2022. PMID: 36035224 Free PMC article.
Herein, we aimed to explore whether GCs cause ferroptosis of BMSCs, identify pathways as possible therapeutic targets, and determine the underlying mechanisms of action. In this study, we used high-dose dexamethasone (DEX) to observe whether GCs induce ferroptosis of BMSCs …
Herein, we aimed to explore whether GCs cause ferroptosis of BMSCs, identify pathways as possible therapeutic targets, and determine the und …
Exosomes derived from human platelet-rich plasma prevent apoptosis induced by glucocorticoid-associated endoplasmic reticulum stress in rat osteonecrosis of the femoral head via the Akt/Bad/Bcl-2 signal pathway.
Tao SC, Yuan T, Rui BY, Zhu ZZ, Guo SC, Zhang CQ. Tao SC, et al. Theranostics. 2017 Jan 15;7(3):733-750. doi: 10.7150/thno.17450. eCollection 2017. Theranostics. 2017. PMID: 28255363 Free PMC article.
Consequently, we hypothesized that PRP-Exos prevent apoptosis induced by glucocorticoid-associated ER stress in rat ONFH via the Akt/Bad/Bcl-2 signal pathway. To verify this hypothesis, a dexamethasone (DEX)-treated in vitro cell model and methylprednisolone (MPS)-treated …
Consequently, we hypothesized that PRP-Exos prevent apoptosis induced by glucocorticoid-associated ER stress in rat ONFH via the Akt/Bad/Bcl …
Dexmedetomidine attenuates sleep deprivation-induced inhibition of hippocampal neurogenesis via VEGF-VEGFR2 signaling and inhibits neuroinflammation.
Zhang S, Zhang Y, Zheng Y, Zhu S, Sun J, Deng Y, Wang Q, Zhai Q. Zhang S, et al. Biomed Pharmacother. 2023 Sep;165:115085. doi: 10.1016/j.biopha.2023.115085. Epub 2023 Jun 29. Biomed Pharmacother. 2023. PMID: 37392656 Free article.
Long periods of sleep deprivation (SD) have serious effects on health. While the alpha(2) adrenoceptor agonist dexmedetomidine (DEX) can improve sleep quality for patients who have insomnia, the effect of DEX on cognition and mechanisms after SD remains elusive. ... …
Long periods of sleep deprivation (SD) have serious effects on health. While the alpha(2) adrenoceptor agonist dexmedetomidine (DEX) …
Intravitreal dexamethasone implants facilitate the management of refractory Behçet's uveitis with vasculitis.
Tao T, Yang S, He D, Li Z, Chen B, Zhu L, Su W. Tao T, et al. Clin Immunol. 2023 Jun;251:109633. doi: 10.1016/j.clim.2023.109633. Epub 2023 May 5. Clin Immunol. 2023. PMID: 37150241 Free article.
To investigate the efficacy and safety of dexamethasone (DEX) implant, Ozurdex , as an adjunctive treatment for refractory Behcet's uveitis (BU), a total of 61 patients (80 eyes) were included in this cross-sectional study and divided into the non-DEX and DEX …
To investigate the efficacy and safety of dexamethasone (DEX) implant, Ozurdex , as an adjunctive treatment for refractory Behcet's u …
JUN mediates glucocorticoid resistance by stabilizing HIF1a in T cell acute lymphoblastic leukemia.
Zhang Z, Shi J, Wu Q, Zhang Z, Liu X, Ren A, Zhao G, Dong G, Wu H, Zhao J, Zhao Y, Hu J, Li H, Zhang T, Zhou F, Zhu H. Zhang Z, et al. iScience. 2023 Oct 18;26(11):108242. doi: 10.1016/j.isci.2023.108242. eCollection 2023 Nov 17. iScience. 2023. PMID: 38026210 Free PMC article.
Dexamethasone (Dex) plays a critical role in T-ALL treatment, but the mechanisms of Dex resistance are poorly understood. Here, we demonstrated that the expression of JUN was regulated in Dex-resistant T-ALL cell lines and patient samples. JUN knockdown incre …
Dexamethasone (Dex) plays a critical role in T-ALL treatment, but the mechanisms of Dex resistance are poorly understood. Here …
A comparative study of the neuroprotective effects of dl-3-n-butylphthalide and edaravone dexborneol on cerebral ischemic stroke rats.
Zhang H, Wang L, Zhu B, Yang Y, Cai C, Wang X, Deng L, He B, Cui Y, Zhou W. Zhang H, et al. Eur J Pharmacol. 2023 Jul 15;951:175801. doi: 10.1016/j.ejphar.2023.175801. Epub 2023 May 18. Eur J Pharmacol. 2023. PMID: 37207969
INTRODUCTION: DL-3-n-butylphthalide (NBP) and edaravone dexborneol (Eda-Dex) are two promising reagents for stroke treatment. However, the impacts of NBP and Eda-Dex on poststroke mental deficits are still poorly understood. ...In addition, NBP and Eda-Dex di …
INTRODUCTION: DL-3-n-butylphthalide (NBP) and edaravone dexborneol (Eda-Dex) are two promising reagents for stroke treatment. However …
Dexmedetomidine attenuates neuroinflammation and microglia activation in LPS-stimulated BV2 microglia cells through targeting circ-Shank3/miR-140-3p/TLR4 axis.
He G, He Y, Ni H, Wang K, Zhu Y, Bao Y. He G, et al. Eur J Histochem. 2023 Jul 26;67(3):3766. doi: 10.4081/ejh.2023.3766. Eur J Histochem. 2023. PMID: 37491974 Free PMC article.
It has been shown that dexmedetomidine (Dex) could attenuate postoperative cognitive dysfunction (POCD) via targeting circular RNAs (circRNAs). ...Our results might shed a new light on the mechanism of Dex for the treatment of POCD....
It has been shown that dexmedetomidine (Dex) could attenuate postoperative cognitive dysfunction (POCD) via targeting circular RNAs ( …
331 results