High-fat diet-induced obesity leads to increased NO sensitivity of rat coronary arterioles: role of soluble guanylate cyclase activation.
Jebelovszki E, Kiraly C, Erdei N, Feher A, Pasztor ET, Rutkai I, Forster T, Edes I, Koller A, Bagi Z.
Jebelovszki E, et al.
Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2558-64. doi: 10.1152/ajpheart.01198.2007. Epub 2008 Apr 11.
Am J Physiol Heart Circ Physiol. 2008.
PMID: 18408126
Free article.
We found that dilations to acetylcholine (ACh) were not significantly different in obese and lean rats (lean, 83 +/- 4%; and obese, 85 +/- 3% at 1 microM), yet the inhibition of NO synthesis with N(omega)-nitro-l-arginine methyl ester reduced ACh-induced dilations only in …
We found that dilations to acetylcholine (ACh) were not significantly different in obese and lean rats (lean, 83 +/- 4%; and obese, 85 +/- 3 …